SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gos'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_A_9CRA131_1
(TRANSTHYRETIN)		 4gos V-SET
DOMAIN-CONTAINING
T-CELL ACTIVATION
INHIBITOR 1
(Homo
sapiens) 		4 / 6 LEU A 115
LEU A  54
SER A  44
THR A  41
 None
 1.13A 1tyrA-4gosA:
3.3		 1tyrA-4gosA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		 4gos V-SET
DOMAIN-CONTAINING
T-CELL ACTIVATION
INHIBITOR 1
(Homo
sapiens) 		4 / 7 SER A  55
SER A 114
ASN A 112
GLN A 107
 NAG  A 202 ( 4.5A)
NAG  A 201 (-3.2A)
NAG  A 201 (-1.9A)
NAG  A 201 (-4.7A)
 1.06A 2cmlA-4gosA:
undetectable		 2cmlA-4gosA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		 4gos V-SET
DOMAIN-CONTAINING
T-CELL ACTIVATION
INHIBITOR 1
(Homo
sapiens) 		4 / 8 SER A  55
SER A 114
ASN A 112
GLN A 107
 NAG  A 202 ( 4.5A)
NAG  A 201 (-3.2A)
NAG  A 201 (-1.9A)
NAG  A 201 (-4.7A)
 1.10A 2cmlB-4gosA:
undetectable		 2cmlB-4gosA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		 4gos V-SET
DOMAIN-CONTAINING
T-CELL ACTIVATION
INHIBITOR 1
(Homo
sapiens) 		4 / 8 SER A  55
SER A 114
ASN A 112
GLN A 107
 NAG  A 202 ( 4.5A)
NAG  A 201 (-3.2A)
NAG  A 201 (-1.9A)
NAG  A 201 (-4.7A)
 1.05A 2cmlD-4gosA:
undetectable		 2cmlD-4gosA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 4gos V-SET
DOMAIN-CONTAINING
T-CELL ACTIVATION
INHIBITOR 1
(Homo
sapiens) 		5 / 11 THR A  40
THR A  41
ALA A 141
GLY A 111
ALA A 113
 None
 1.22A 2f16N-4gosA:
undetectable		 2f16N-4gosA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_A_T44A128_1
(TRANSTHYRETIN)		 4gos V-SET
DOMAIN-CONTAINING
T-CELL ACTIVATION
INHIBITOR 1
(Homo
sapiens) 		5 / 9 LEU A 115
LEU A  54
SER A  44
THR A  41
VAL A  39
 None
 1.06A 3ozkA-4gosA:
3.4		 3ozkA-4gosA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CD2_A_FOLA207_0
(DIHYDROFOLATE
REDUCTASE)		 4gos V-SET
DOMAIN-CONTAINING
T-CELL ACTIVATION
INHIBITOR 1
(Homo
sapiens) 		5 / 12 ALA A 102
ILE A  69
PHE A  83
LEU A  64
THR A 101
 None
 1.29A 4cd2A-4gosA:
undetectable		 4cd2A-4gosA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4gos V-SET
DOMAIN-CONTAINING
T-CELL ACTIVATION
INHIBITOR 1
(Homo
sapiens) 		5 / 12 THR A  40
THR A  41
ALA A 141
GLY A 111
ALA A 113
 None
 1.24A 4qvnV-4gosA:
undetectable
4qvnb-4gosA:
undetectable		 4qvnV-4gosA:
18.64
4qvnb-4gosA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4gos V-SET
DOMAIN-CONTAINING
T-CELL ACTIVATION
INHIBITOR 1
(Homo
sapiens) 		5 / 12 THR A  40
THR A  41
ALA A 141
GLY A 111
ALA A 113
 None
 1.23A 4qvnH-4gosA:
undetectable
4qvnN-4gosA:
undetectable		 4qvnH-4gosA:
18.64
4qvnN-4gosA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_B_BO2B201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		 4gos V-SET
DOMAIN-CONTAINING
T-CELL ACTIVATION
INHIBITOR 1
(Homo
sapiens) 		5 / 12 THR A  40
THR A  41
ALA A 141
GLY A 111
ALA A 113
 None
 1.21A 6hwdV-4gosA:
undetectable
6hwdb-4gosA:
undetectable		 6hwdV-4gosA:
20.00
6hwdb-4gosA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_N_BO2N201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		 4gos V-SET
DOMAIN-CONTAINING
T-CELL ACTIVATION
INHIBITOR 1
(Homo
sapiens) 		5 / 12 THR A  40
THR A  41
ALA A 141
GLY A 111
ALA A 113
 None
 1.20A 6hwdH-4gosA:
undetectable
6hwdN-4gosA:
undetectable		 6hwdH-4gosA:
20.00
6hwdN-4gosA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_A_LLLA301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4gos V-SET
DOMAIN-CONTAINING
T-CELL ACTIVATION
INHIBITOR 1
(Homo
sapiens) 		4 / 6 ASP A 124
TYR A 128
ASP A  94
GLU A  95
 None
 1.45A 6mn5A-4gosA:
undetectable		 6mn5A-4gosA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_C_LLLC301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4gos V-SET
DOMAIN-CONTAINING
T-CELL ACTIVATION
INHIBITOR 1
(Homo
sapiens) 		4 / 6 ASP A 124
TYR A 128
ASP A  94
GLU A  95
 None
 1.47A 6mn5C-4gosA:
undetectable		 6mn5C-4gosA:
20.91