SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gou'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT3_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4gou EHRGS-RHOGEF
(Entamoeba
histolytica) 		4 / 7 LEU A 147
LEU A  28
LEU A 149
GLN A 151
 None
 1.03A 1kt3A-4gouA:
undetectable		 1kt3A-4gouA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		 4gou EHRGS-RHOGEF
(Entamoeba
histolytica) 		4 / 7 THR A 126
TYR A 125
ASN A  41
LEU A  29
 None
 0.98A 1qzrB-4gouA:
undetectable		 1qzrB-4gouA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4gou EHRGS-RHOGEF
(Entamoeba
histolytica) 		4 / 5 GLY A 297
PRO A 304
VAL A 305
ILE A 221
 None
 0.75A 2aoiA-4gouA:
undetectable		 2aoiA-4gouA:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_B_FOLB2161_0
(DIHYDROFOLATE
REDUCTASE)		 4gou EHRGS-RHOGEF
(Entamoeba
histolytica) 		5 / 12 LEU A 165
THR A 435
ILE A 437
LEU A 388
ILE A 451
 None
 0.97A 2d0kB-4gouA:
undetectable		 2d0kB-4gouA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4gou EHRGS-RHOGEF
(Entamoeba
histolytica) 		5 / 12 ALA A 385
VAL A 450
TRP A 176
GLY A 406
ILE A 407
 None
 1.03A 2dcfA-4gouA:
undetectable		 2dcfA-4gouA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_E_MTXE621_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4gou EHRGS-RHOGEF
(Entamoeba
histolytica) 		5 / 12 LEU A 322
PHE A 212
SER A 213
ILE A 288
LEU A 222
 None
 1.00A 2oipE-4gouA:
undetectable		 2oipE-4gouA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_B_ADNB2_1
(YTAA PROTEIN)		 4gou EHRGS-RHOGEF
(Entamoeba
histolytica) 		4 / 6 ILE A 137
PRO A  14
LEU A  10
ILE A 129
 None
 1.02A 2q83B-4gouA:
2.5		 2q83B-4gouA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_C_VDYC6178_1
(VITAMIN D
HYDROXYLASE)		 4gou EHRGS-RHOGEF
(Entamoeba
histolytica) 		5 / 12 MET A 216
ILE A 221
LEU A 222
ASN A 281
ILE A 306
 None
 1.16A 3a51C-4gouA:
2.1		 3a51C-4gouA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A65_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4gou EHRGS-RHOGEF
(Entamoeba
histolytica) 		5 / 12 ALA A 385
VAL A 450
TRP A 176
GLY A 406
ILE A 407
 None
 1.04A 3a65A-4gouA:
undetectable		 3a65A-4gouA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_D_MTXD615_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4gou EHRGS-RHOGEF
(Entamoeba
histolytica) 		5 / 12 LEU A 322
PHE A 212
SER A 213
ILE A 288
LEU A 222
 None
 0.90A 3hj3D-4gouA:
undetectable		 3hj3D-4gouA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_N_TFPN201_1
(PROTEIN S100-A4)		 4gou EHRGS-RHOGEF
(Entamoeba
histolytica) 		5 / 10 PHE A 401
GLY A 403
CYH A 408
ILE A 407
PHE A 468
 None
 1.28A 3ko0L-4gouA:
1.7
3ko0N-4gouA:
1.3		 3ko0L-4gouA:
13.66
3ko0N-4gouA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_R_TFPR201_1
(PROTEIN S100-A4)		 4gou EHRGS-RHOGEF
(Entamoeba
histolytica) 		5 / 10 CYH A 408
ILE A 407
PHE A 468
PHE A 401
GLY A 403
 None
 1.24A 3ko0R-4gouA:
1.0
3ko0T-4gouA:
1.0		 3ko0R-4gouA:
13.66
3ko0T-4gouA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_A_NCAA1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 4gou EHRGS-RHOGEF
(Entamoeba
histolytica) 		4 / 7 THR A  15
HIS A 233
TYR A 273
TYR A 125
 None
 1.30A 4a3uA-4gouA:
undetectable		 4a3uA-4gouA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_NCAB1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 4gou EHRGS-RHOGEF
(Entamoeba
histolytica) 		4 / 7 THR A  15
HIS A 233
TYR A 273
TYR A 125
 None
 1.30A 4a3uB-4gouA:
undetectable		 4a3uB-4gouA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF2_A_4CHA506_0
(NADPH DEHYDROGENASE)		 4gou EHRGS-RHOGEF
(Entamoeba
histolytica) 		4 / 6 THR A  15
HIS A 233
TYR A 273
TYR A 125
 None
 1.24A 4df2A-4gouA:
undetectable		 4df2A-4gouA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_C_NCTC501_1
(CYTOCHROME P450 2A13)		 4gou EHRGS-RHOGEF
(Entamoeba
histolytica) 		4 / 7 PHE A 212
PHE A 231
LEU A 322
LEU A 325
 None
 0.75A 4ejgC-4gouA:
undetectable		 4ejgC-4gouA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFJ_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 4gou EHRGS-RHOGEF
(Entamoeba
histolytica) 		5 / 12 ILE A 438
ALA A 411
LEU A 413
ILE A 497
VAL A 443
 None
 1.06A 4kfjB-4gouA:
undetectable		 4kfjB-4gouA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX6_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4gou EHRGS-RHOGEF
(Entamoeba
histolytica) 		5 / 12 LEU A 165
THR A 435
ILE A 437
LEU A 388
ILE A 451
 None
 1.06A 4nx6A-4gouA:
undetectable		 4nx6A-4gouA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX7_A_FOLA202_0
(DIHYDROFOLATE
REDUCTASE)		 4gou EHRGS-RHOGEF
(Entamoeba
histolytica) 		5 / 12 LEU A 165
THR A 435
ILE A 437
LEU A 388
ILE A 451
 None
 1.08A 4nx7A-4gouA:
undetectable		 4nx7A-4gouA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 4gou EHRGS-RHOGEF
(Entamoeba
histolytica) 		5 / 12 LEU A 400
ILE A 474
ILE A 438
VAL A 450
LEU A 389
 None
 0.99A 4y8wC-4gouA:
undetectable		 4y8wC-4gouA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_2
(CDL2.2)		 4gou EHRGS-RHOGEF
(Entamoeba
histolytica) 		5 / 12 TRP A  13
LEU A 132
ILE A 365
TYR A 271
LEU A 369
 None
 1.12A 5ienB-4gouA:
undetectable		 5ienB-4gouA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_A_NCAA402_0
(NADPH DEHYDROGENASE
3)		 4gou EHRGS-RHOGEF
(Entamoeba
histolytica) 		4 / 8 THR A  15
HIS A 233
TYR A 273
TYR A 125
 None
 1.33A 5v4vA-4gouA:
undetectable		 5v4vA-4gouA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_B_NCAB402_0
(NADPH DEHYDROGENASE
3)		 4gou EHRGS-RHOGEF
(Entamoeba
histolytica) 		4 / 8 THR A  15
HIS A 233
TYR A 273
TYR A 125
 None
 1.32A 5v4vB-4gouA:
undetectable		 5v4vB-4gouA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_1
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 4gou EHRGS-RHOGEF
(Entamoeba
histolytica) 		3 / 3 ASP A 232
SER A 210
SER A 213
 None
 0.81A 6mxtA-4gouA:
2.2		 6mxtA-4gouA:
22.28