SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gow'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1A29_A_TFPA154_1
(CALMODULIN)		 4gow CALMODULIN
(Homo
sapiens) 		5 / 10 LEU D  18
MET D 109
GLU D 114
LEU D 116
MET D 124
 LEU  D  18 ( 0.6A)
MET  D 109 ( 0.0A)
GLU  D 114 ( 0.6A)
LEU  D 116 ( 0.6A)
MET  D 124 ( 0.0A)
 1.27A 1a29A-4gowD:
14.6		 1a29A-4gowD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1A29_A_TFPA154_1
(CALMODULIN)		 4gow CALMODULIN
(Homo
sapiens) 		5 / 10 MET D 109
LEU D 116
GLU D 120
GLU D 123
MET D 124
 MET  D 109 ( 0.0A)
LEU  D 116 ( 0.6A)
GLU  D 120 ( 0.6A)
GLU  D 123 ( 0.6A)
MET  D 124 ( 0.0A)
 1.12A 1a29A-4gowD:
14.6		 1a29A-4gowD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CTR_A_TFPA153_1
(CALMODULIN)		 4gow CALMODULIN
(Homo
sapiens) 		6 / 9 ILE D 100
GLU D 123
GLU D 127
ALA D 128
VAL D 136
MET D 144
 ILE  D 100 ( 0.7A)
GLU  D 123 ( 0.6A)
GLU  D 127 ( 0.6A)
ALA  D 128 ( 0.0A)
VAL  D 136 ( 0.6A)
MET  D 144 ( 0.0A)
 1.27A 1ctrA-4gowD:
17.2		 1ctrA-4gowD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CTR_A_TFPA153_1
(CALMODULIN)		 4gow CALMODULIN
(Homo
sapiens) 		6 / 9 ILE D 100
LEU D 105
GLU D 127
ALA D 128
VAL D 136
MET D 144
 ILE  D 100 ( 0.7A)
LEU  D 105 ( 0.6A)
GLU  D 127 ( 0.6A)
ALA  D 128 ( 0.0A)
VAL  D 136 ( 0.6A)
MET  D 144 ( 0.0A)
 1.00A 1ctrA-4gowD:
17.2		 1ctrA-4gowD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CTR_A_TFPA153_1
(CALMODULIN)		 4gow CALMODULIN
(Homo
sapiens) 		6 / 9 ILE D 100
LEU D 105
MET D 124
GLU D 127
ALA D 128
VAL D 136
 ILE  D 100 ( 0.7A)
LEU  D 105 ( 0.6A)
MET  D 124 ( 0.0A)
GLU  D 127 ( 0.6A)
ALA  D 128 ( 0.0A)
VAL  D 136 ( 0.6A)
 0.71A 1ctrA-4gowD:
17.2		 1ctrA-4gowD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		 4gow CALMODULIN
(Homo
sapiens) 		6 / 11 ILE D 100
LEU D 105
MET D 109
LEU D 112
MET D 124
MET D 144
 ILE  D 100 ( 0.7A)
LEU  D 105 ( 0.6A)
MET  D 109 ( 0.0A)
LEU  D 112 ( 0.6A)
MET  D 124 ( 0.0A)
MET  D 144 ( 0.0A)
 0.96A 1dtlA-4gowD:
12.2		 1dtlA-4gowD:
53.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		 4gow CALMODULIN
(Homo
sapiens) 		6 / 11 ILE D 100
LEU D 105
MET D 109
LEU D 112
MET D 124
MET D 145
 ILE  D 100 ( 0.7A)
LEU  D 105 ( 0.6A)
MET  D 109 ( 0.0A)
LEU  D 112 ( 0.6A)
MET  D 124 ( 0.0A)
MET  D 145 ( 0.0A)
 1.33A 1dtlA-4gowD:
12.2		 1dtlA-4gowD:
53.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		 4gow CALMODULIN
(Homo
sapiens) 		6 / 11 ILE D 100
LEU D 105
MET D 109
LEU D 112
MET D 145
LEU D  18
 ILE  D 100 ( 0.7A)
LEU  D 105 ( 0.6A)
MET  D 109 ( 0.0A)
LEU  D 112 ( 0.6A)
MET  D 145 ( 0.0A)
LEU  D  18 ( 0.6A)
 1.35A 1dtlA-4gowD:
12.2		 1dtlA-4gowD:
53.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		 4gow CALMODULIN
(Homo
sapiens) 		8 / 11 PHE D  19
ILE D  27
LEU D  32
MET D  36
LEU D  39
MET D  51
VAL D  55
MET D  71
 PHE  D  19 ( 1.3A)
ILE  D  27 ( 0.7A)
LEU  D  32 ( 0.6A)
MET  D  36 ( 0.0A)
LEU  D  39 ( 0.5A)
MET  D  51 ( 0.0A)
VAL  D  55 ( 0.6A)
MET  D  71 ( 0.0A)
 0.74A 1dtlA-4gowD:
12.2		 1dtlA-4gowD:
53.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		 4gow CALMODULIN
(Homo
sapiens) 		6 / 11 PHE D  92
ILE D 100
LEU D 105
LEU D 112
MET D 124
MET D 144
 PHE  D  92 ( 1.3A)
ILE  D 100 ( 0.7A)
LEU  D 105 ( 0.6A)
LEU  D 112 ( 0.6A)
MET  D 124 ( 0.0A)
MET  D 144 ( 0.0A)
 0.79A 1dtlA-4gowD:
12.2		 1dtlA-4gowD:
53.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		 4gow CALMODULIN
(Homo
sapiens) 		6 / 11 PHE D  92
ILE D 100
LEU D 105
LEU D 112
MET D 124
MET D 145
 PHE  D  92 ( 1.3A)
ILE  D 100 ( 0.7A)
LEU  D 105 ( 0.6A)
LEU  D 112 ( 0.6A)
MET  D 124 ( 0.0A)
MET  D 145 ( 0.0A)
 1.26A 1dtlA-4gowD:
12.2		 1dtlA-4gowD:
53.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		 4gow CALMODULIN
(Homo
sapiens) 		6 / 11 PHE D  92
ILE D 100
LEU D 105
LEU D 112
MET D 145
LEU D  18
 PHE  D  92 ( 1.3A)
ILE  D 100 ( 0.7A)
LEU  D 105 ( 0.6A)
LEU  D 112 ( 0.6A)
MET  D 145 ( 0.0A)
LEU  D  18 ( 0.6A)
 1.29A 1dtlA-4gowD:
12.2		 1dtlA-4gowD:
53.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		 4gow CALMODULIN
(Homo
sapiens) 		4 / 8 MET D  36
GLN D  41
PRO D  43
GLU D  47
 MET  D  36 ( 0.0A)
GLN  D  41 ( 0.6A)
PRO  D  43 ( 1.1A)
GLU  D  47 ( 0.5A)
 1.06A 1dtlA-4gowD:
12.2		 1dtlA-4gowD:
53.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4gow CALMODULIN
(Homo
sapiens) 		7 / 12 ILE D 100
LEU D 105
MET D 109
MET D 124
ILE D 125
VAL D 136
MET D 145
 ILE  D 100 ( 0.7A)
LEU  D 105 ( 0.6A)
MET  D 109 ( 0.0A)
MET  D 124 ( 0.0A)
ILE  D 125 ( 0.4A)
VAL  D 136 ( 0.6A)
MET  D 145 ( 0.0A)
 1.07A 1lxfC-4gowD:
9.8		 1lxfC-4gowD:
67.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4gow CALMODULIN
(Homo
sapiens) 		7 / 12 LEU D 105
MET D 109
MET D 124
ILE D 125
VAL D 136
MET D 144
MET D 145
 LEU  D 105 ( 0.6A)
MET  D 109 ( 0.0A)
MET  D 124 ( 0.0A)
ILE  D 125 ( 0.4A)
VAL  D 136 ( 0.6A)
MET  D 144 ( 0.0A)
MET  D 145 ( 0.0A)
 1.31A 1lxfC-4gowD:
9.8		 1lxfC-4gowD:
67.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4gow CALMODULIN
(Homo
sapiens) 		7 / 12 PHE D  92
ILE D 100
LEU D 105
MET D 124
ILE D 125
VAL D 136
MET D 145
 PHE  D  92 ( 1.3A)
ILE  D 100 ( 0.7A)
LEU  D 105 ( 0.6A)
MET  D 124 ( 0.0A)
ILE  D 125 ( 0.4A)
VAL  D 136 ( 0.6A)
MET  D 145 ( 0.0A)
 0.78A 1lxfC-4gowD:
9.8		 1lxfC-4gowD:
67.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4gow CALMODULIN
(Homo
sapiens) 		6 / 12 PHE D  92
LEU D 105
MET D 124
ILE D 125
GLU D 127
VAL D 136
 PHE  D  92 ( 1.3A)
LEU  D 105 ( 0.6A)
MET  D 124 ( 0.0A)
ILE  D 125 ( 0.4A)
GLU  D 127 ( 0.6A)
VAL  D 136 ( 0.6A)
 0.94A 1lxfC-4gowD:
9.8		 1lxfC-4gowD:
67.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WRL_C_TFPC208_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4gow CALMODULIN
(Homo
sapiens) 		4 / 5 PHE D  92
LEU D 112
PHE D 141
MET D 145
 PHE  D  92 ( 1.3A)
LEU  D 112 ( 0.6A)
PHE  D 141 ( 1.3A)
MET  D 145 ( 0.0A)
 1.05A 1wrlC-4gowD:
11.4		 1wrlC-4gowD:
67.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WRL_F_TFPF209_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4gow CALMODULIN
(Homo
sapiens) 		5 / 10 LEU D  18
GLU D 120
MET D 124
MET D 144
MET D 145
 LEU  D  18 ( 0.6A)
GLU  D 120 ( 0.6A)
MET  D 124 ( 0.0A)
MET  D 144 ( 0.0A)
MET  D 145 ( 0.0A)
 1.03A 1wrlE-4gowD:
11.4
1wrlF-4gowD:
11.3		 1wrlE-4gowD:
67.09
1wrlF-4gowD:
67.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS4_A_AZMA702_1
(CARBONIC ANHYDRASE 2)		 4gow CALMODULIN
(Homo
sapiens) 		4 / 7 VAL D 142
TYR D 138
LYS D  81
GLU D  83
 VAL  D 142 ( 0.6A)
TYR  D 138 ( 1.3A)
SER  D  81 ( 0.0A)
GLU  D  83 ( 0.5A)
 1.20A 3hs4A-4gowD:
undetectable		 3hs4A-4gowD:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_A_TYLA2200_1
(CREB-BINDING PROTEIN)		 4gow CALMODULIN
POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY
KQT MEMBER 4
(Homo
sapiens) 		4 / 6 VAL D 108
LEU D 105
ILE D 100
VAL A 530
 VAL  D 108 ( 0.6A)
LEU  D 105 ( 0.6A)
ILE  D 100 ( 0.7A)
VAL  A 530 ( 0.6A)
 0.63A 4a9kA-4gowD:
undetectable		 4a9kA-4gowD:
23.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RJD_A_TFPA203_1
(CALMODULIN)		 4gow CALMODULIN
(Homo
sapiens) 		7 / 8 ILE D 100
LEU D 105
MET D 109
MET D 124
ALA D 128
VAL D 136
MET D 144
 ILE  D 100 ( 0.7A)
LEU  D 105 ( 0.6A)
MET  D 109 ( 0.0A)
MET  D 124 ( 0.0A)
ALA  D 128 ( 0.0A)
VAL  D 136 ( 0.6A)
MET  D 144 ( 0.0A)
 0.80A 4rjdA-4gowD:
12.6		 4rjdA-4gowD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RJD_A_TFPA203_1
(CALMODULIN)		 4gow CALMODULIN
(Homo
sapiens) 		4 / 8 PHE D  19
ILE D  27
LEU D  32
MET D  51
 PHE  D  19 ( 1.3A)
ILE  D  27 ( 0.7A)
LEU  D  32 ( 0.6A)
MET  D  51 ( 0.0A)
 0.56A 4rjdA-4gowD:
12.6		 4rjdA-4gowD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RJD_A_TFPA203_1
(CALMODULIN)		 4gow CALMODULIN
(Homo
sapiens) 		7 / 8 PHE D  92
ILE D 100
LEU D 105
MET D 109
MET D 124
ALA D 128
VAL D 136
 PHE  D  92 ( 1.3A)
ILE  D 100 ( 0.7A)
LEU  D 105 ( 0.6A)
MET  D 109 ( 0.0A)
MET  D 124 ( 0.0A)
ALA  D 128 ( 0.0A)
VAL  D 136 ( 0.6A)
 0.65A 4rjdA-4gowD:
12.6		 4rjdA-4gowD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RJD_B_TFPB203_1
(CALMODULIN)		 4gow CALMODULIN
(Homo
sapiens) 		5 / 7 PHE D  19
LEU D  32
MET D  36
MET D  71
MET D  72
 PHE  D  19 ( 1.3A)
LEU  D  32 ( 0.6A)
MET  D  36 ( 0.0A)
MET  D  71 ( 0.0A)
MET  D  72 ( 0.0A)
 1.16A 4rjdB-4gowD:
12.6		 4rjdB-4gowD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RJD_B_TFPB203_1
(CALMODULIN)		 4gow CALMODULIN
(Homo
sapiens) 		5 / 7 PHE D  19
LEU D  32
MET D  51
MET D  71
MET D  72
 PHE  D  19 ( 1.3A)
LEU  D  32 ( 0.6A)
MET  D  51 ( 0.0A)
MET  D  71 ( 0.0A)
MET  D  72 ( 0.0A)
 0.67A 4rjdB-4gowD:
12.6		 4rjdB-4gowD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RJD_B_TFPB203_1
(CALMODULIN)		 4gow CALMODULIN
(Homo
sapiens) 		7 / 7 PHE D  92
LEU D 105
MET D 109
MET D 124
ALA D 128
MET D 144
MET D 145
 PHE  D  92 ( 1.3A)
LEU  D 105 ( 0.6A)
MET  D 109 ( 0.0A)
MET  D 124 ( 0.0A)
ALA  D 128 ( 0.0A)
MET  D 144 ( 0.0A)
MET  D 145 ( 0.0A)
 0.93A 4rjdB-4gowD:
12.6		 4rjdB-4gowD:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V02_R_657R201_0
(CALMODULIN-1
SMALL CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 2)		 4gow CALMODULIN
(Homo
sapiens) 		6 / 10 LEU D  32
MET D  51
GLU D  54
VAL D  55
ILE D  63
MET D  72
 LEU  D  32 ( 0.6A)
MET  D  51 ( 0.0A)
GLU  D  54 ( 0.5A)
VAL  D  55 ( 0.6A)
ILE  D  63 ( 0.7A)
MET  D  72 ( 0.0A)
 0.71A 5v02B-4gowD:
undetectable
5v02R-4gowD:
14.5		 5v02B-4gowD:
19.86
5v02R-4gowD:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 4gow POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY
KQT MEMBER 4
CALMODULIN
(Homo
sapiens;
Homo
sapiens) 		5 / 12 VAL A 533
THR A 532
LEU D 112
PHE D  92
VAL D  91
 VAL  A 533 ( 0.6A)
THR  A 532 ( 0.8A)
LEU  D 112 ( 0.6A)
PHE  D  92 ( 1.3A)
VAL  D  91 ( 0.6A)
 1.08A 6a94B-4gowA:
undetectable		 6a94B-4gowA:
14.34