SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gox'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		 4gox POLYKETIDE SYNTHASE
(Synechococcus
sp.
PCC
7002) 		4 / 5 TYR A 248
LEU A 229
THR A  43
ARG A  46
 A3P  A 401 (-4.6A)
None
A3P  A 401 (-3.6A)
None
 1.36A 1i2wA-4goxA:
undetectable		 1i2wA-4goxA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_B_FFOB361_0
(DIHYDROFOLATE
REDUCTASE)		 4gox POLYKETIDE SYNTHASE
(Synechococcus
sp.
PCC
7002) 		5 / 12 ILE A  31
LEU A  35
PHE A  33
LEU A  64
PRO A  65
 None
 1.13A 1jolB-4goxA:
undetectable		 1jolB-4goxA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_B_DVAB6_0
(GRAMICIDIN D)		 4gox POLYKETIDE SYNTHASE
(Synechococcus
sp.
PCC
7002) 		3 / 3 TRP A 107
ALA A 102
VAL A 104
 None
 0.85A 2izqA-4goxA:
undetectable
2izqB-4goxA:
undetectable		 2izqA-4goxA:
9.91
2izqB-4goxA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 4gox POLYKETIDE SYNTHASE
(Synechococcus
sp.
PCC
7002) 		3 / 3 THR A 196
ASP A 145
SER A 147
 None
 0.84A 2nxeA-4goxA:
undetectable		 2nxeA-4goxA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 4gox POLYKETIDE SYNTHASE
(Synechococcus
sp.
PCC
7002) 		3 / 3 THR A 196
ASP A 145
SER A 147
 None
 0.78A 2nxeB-4goxA:
undetectable		 2nxeB-4goxA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		 4gox POLYKETIDE SYNTHASE
(Synechococcus
sp.
PCC
7002) 		4 / 8 ASP A 241
ARG A 252
GLY A  51
PRO A  53
 None
 0.93A 2ys6A-4goxA:
2.2		 2ys6A-4goxA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4gox POLYKETIDE SYNTHASE
(Synechococcus
sp.
PCC
7002) 		5 / 12 LEU A 173
PHE A 269
LEU A  44
LEU A 279
TYR A 218
 None
A3P  A 401 (-4.7A)
A3P  A 401 (-3.8A)
A3P  A 401 (-3.9A)
A3P  A 401 (-4.8A)
 1.49A 3adsA-4goxA:
undetectable		 3adsA-4goxA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4gox POLYKETIDE SYNTHASE
(Synechococcus
sp.
PCC
7002) 		4 / 7 LEU A 159
ARG A  46
SER A 169
GLY A 265
 None
None
A3P  A 401 (-2.6A)
None
 1.03A 3hcrB-4goxA:
2.3		 3hcrB-4goxA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UY4_A_PAUA302_0
(PANTOTHENATE
SYNTHETASE)		 4gox POLYKETIDE SYNTHASE
(Synechococcus
sp.
PCC
7002) 		4 / 8 HIS A 272
VAL A 222
ASP A 266
ARG A 172
 A3P  A 401 (-3.9A)
A3P  A 401 ( 4.9A)
A3P  A 401 (-3.8A)
A3P  A 401 (-2.9A)
 1.17A 3uy4A-4goxA:
undetectable		 3uy4A-4goxA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4gox POLYKETIDE SYNTHASE
(Synechococcus
sp.
PCC
7002) 		3 / 3 ARG A 141
GLU A 148
THR A 207
 None
 0.94A 3v4tA-4goxA:
undetectable		 3v4tA-4goxA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I6X_A_8PRA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4gox POLYKETIDE SYNTHASE
(Synechococcus
sp.
PCC
7002) 		5 / 10 ASP A 132
ILE A 117
TYR A 118
GLY A  82
VAL A 104
 None
 1.23A 5i6xA-4goxA:
undetectable		 5i6xA-4goxA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 4gox POLYKETIDE SYNTHASE
(Synechococcus
sp.
PCC
7002) 		5 / 12 ILE A 157
ASP A 132
LEU A 229
VAL A 228
GLY A 265
 None
 1.03A 5uxdB-4goxA:
undetectable		 5uxdB-4goxA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9K_F_ACTF802_0
(UNCHARACTERIZED
PROTEIN)		 4gox POLYKETIDE SYNTHASE
(Synechococcus
sp.
PCC
7002) 		3 / 3 TYR A 164
ALA A 300
LEU A 292
 None
 0.71A 6d9kF-4goxA:
4.5		 6d9kF-4goxA:
19.34