SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gp1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4003_1
(SERUM ALBUMIN)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		4 / 6 VAL A 294
GLY A 295
ALA A 258
LEU A 262
 None
 0.79A 1e7bB-4gp1A:
undetectable		 1e7bB-4gp1A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		4 / 8 LEU A  97
ARG A 101
PHE A 104
GLY A 105
 None
 0.85A 1fapB-4gp1A:
2.0		 1fapB-4gp1A:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3003_1
(SERUM ALBUMIN)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		4 / 6 HIS A  78
ILE A  77
ALA A 123
VAL A 137
 DMA  A 402 (-3.9A)
None
None
None
 0.90A 1hk1A-4gp1A:
2.2		 1hk1A-4gp1A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 12 ILE A 178
GLY A 186
VAL A 181
ALA A 192
LEU A 327
 None
 0.95A 1kiaC-4gp1A:
undetectable		 1kiaC-4gp1A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 12 ILE A 178
GLY A 186
VAL A 181
ALA A 192
LEU A 327
 None
 0.95A 1nbhB-4gp1A:
undetectable		 1nbhB-4gp1A:
21.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 11 LEU A  82
ASP A  85
ARG A  94
LYS A 184
THR A 185
 None
 0.86A 1rqjA-4gp1A:
30.5		 1rqjA-4gp1A:
31.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 11 LEU A  82
ASP A  85
ASP A  89
ARG A  94
LYS A 184
 None
 0.84A 1rqjA-4gp1A:
30.5		 1rqjA-4gp1A:
31.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 11 SER A  81
LEU A  82
ASP A  85
ARG A  94
THR A 185
 None
 0.86A 1rqjA-4gp1A:
30.5		 1rqjA-4gp1A:
31.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 11 SER A  81
LEU A  82
ASP A  85
ASP A  89
ARG A  94
 None
 0.74A 1rqjA-4gp1A:
30.5		 1rqjA-4gp1A:
31.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 11 LEU A  82
ASP A  85
ASP A  89
ARG A  94
LYS A 184
THR A 185
 None
 0.89A 1rqjB-4gp1A:
30.4		 1rqjB-4gp1A:
31.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 11 SER A  81
LEU A  82
ASP A  85
ASP A  89
ARG A  94
THR A 185
 None
 0.87A 1rqjB-4gp1A:
30.4		 1rqjB-4gp1A:
31.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		4 / 5 GLU A 312
THR A 323
LEU A 327
LEU A 324
 None
 1.22A 1u18B-4gp1A:
undetectable		 1u18B-4gp1A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_1
(AMINOMETHYLTRANSFERA
SE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		3 / 3 ASP A 226
GLU A 148
ARG A  49
 None
None
DMA  A 402 (-3.1A)
 0.83A 1wopA-4gp1A:
undetectable		 1wopA-4gp1A:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE509_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		4 / 6 ASP A 244
GLU A 155
ARG A 250
LYS A 249
 None
 1.12A 1yc2A-4gp1A:
undetectable
1yc2B-4gp1A:
undetectable
1yc2E-4gp1A:
undetectable		 1yc2A-4gp1A:
23.02
1yc2B-4gp1A:
23.02
1yc2E-4gp1A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YHL_A_RISA1400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 11 LEU A  82
ASP A  85
ARG A  94
LYS A 184
THR A 185
 None
 0.95A 1yhlA-4gp1A:
28.4		 1yhlA-4gp1A:
26.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YHL_A_RISA1400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 11 LEU A  82
ASP A  85
ASP A  89
ARG A  94
LYS A 184
 None
 0.90A 1yhlA-4gp1A:
28.4		 1yhlA-4gp1A:
26.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 11 LEU A  82
ASP A  85
ARG A  94
LYS A 184
THR A 185
 None
 0.93A 1yq7A-4gp1A:
27.5		 1yq7A-4gp1A:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 11 LEU A  82
ASP A  85
ASP A  89
ARG A  94
LYS A 184
 None
 0.92A 1yq7A-4gp1A:
27.5		 1yq7A-4gp1A:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 10 LEU A  82
ASP A  85
ARG A  94
LYS A 184
THR A 185
 None
 0.91A 1yv5A-4gp1A:
27.6		 1yv5A-4gp1A:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 10 LEU A  82
ASP A  85
ASP A  89
ARG A  94
LYS A 184
 None
 0.84A 1yv5A-4gp1A:
27.6		 1yv5A-4gp1A:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZW5_A_ZOLA901_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 9 ASP A  85
ASP A  89
ARG A  94
LYS A 184
THR A 185
 None
 1.02A 1zw5A-4gp1A:
27.8		 1zw5A-4gp1A:
27.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_A_ZOLA901_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 9 ASP A  85
ASP A  89
ARG A  94
LYS A 184
THR A 185
 None
 1.05A 2e91A-4gp1A:
23.3		 2e91A-4gp1A:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_B_ZOLB902_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 9 ASP A  85
ASP A  89
ARG A  94
LYS A 184
THR A 185
 None
 1.08A 2e91B-4gp1A:
22.3		 2e91B-4gp1A:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F89_F_210F9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 9 ASP A  85
ASP A  89
ARG A  94
LYS A 184
THR A 185
 None
 1.01A 2f89F-4gp1A:
28.7		 2f89F-4gp1A:
26.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8C_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 11 LEU A  82
ASP A  85
ARG A  94
LYS A 184
THR A 185
 None
 0.95A 2f8cF-4gp1A:
28.7		 2f8cF-4gp1A:
26.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8C_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 11 LEU A  82
ASP A  85
ASP A  89
ARG A  94
LYS A 184
 None
 0.89A 2f8cF-4gp1A:
28.7		 2f8cF-4gp1A:
26.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8Z_F_ZOLF5001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 10 LEU A  82
ASP A  85
ASP A  89
ARG A  94
LYS A 184
THR A 185
 None
 0.96A 2f8zF-4gp1A:
28.8		 2f8zF-4gp1A:
26.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F94_F_BFQF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 12 LEU A  82
ASP A  85
ASP A  89
ARG A  94
LYS A 184
THR A 185
 None
 0.86A 2f94F-4gp1A:
28.2		 2f94F-4gp1A:
26.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9K_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 10 LEU A  82
ASP A  85
ARG A  94
LYS A 184
THR A 185
 None
 0.96A 2f9kF-4gp1A:
28.3		 2f9kF-4gp1A:
26.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9K_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 10 LEU A  82
ASP A  85
ASP A  89
ARG A  94
LYS A 184
 None
 0.92A 2f9kF-4gp1A:
28.3		 2f9kF-4gp1A:
26.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOA_A_3TCA302_1
(DEOXYCYTIDINE KINASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 12 GLU A  18
LEU A  25
TYR A 116
ALA A  20
ARG A  47
 None
 1.19A 2noaA-4gp1A:
undetectable		 2noaA-4gp1A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOA_B_3TCB302_1
(DEOXYCYTIDINE KINASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 11 GLU A  18
LEU A  25
TYR A 116
ALA A  20
ARG A  47
 None
 1.18A 2noaB-4gp1A:
undetectable		 2noaB-4gp1A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_A_RISA400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 9 LEU A  82
ASP A  85
ASP A  89
ARG A  94
LYS A 184
 None
 0.81A 2o1oA-4gp1A:
26.5		 2o1oA-4gp1A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_A_RISA400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 9 LEU A  82
ASP A  85
ASP A  89
ARG A  94
THR A 185
 None
 0.61A 2o1oA-4gp1A:
26.5		 2o1oA-4gp1A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_B_RISB400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 10 LEU A  82
ASP A  85
ASP A  89
ARG A  94
LYS A 184
 None
 0.88A 2o1oB-4gp1A:
27.2		 2o1oB-4gp1A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 10 LEU A  82
ASP A  85
ARG A  94
LYS A 184
THR A 185
 None
 1.09A 2q58A-4gp1A:
26.5		 2q58A-4gp1A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 10 LEU A  82
ASP A  85
ARG A  94
THR A 185
ASP A 225
 None
 1.37A 2q58A-4gp1A:
26.5		 2q58A-4gp1A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 10 LEU A  82
ASP A  85
ASP A  89
ARG A  94
ASP A 229
 None
 1.13A 2q58A-4gp1A:
26.5		 2q58A-4gp1A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 10 LEU A  82
ASP A  85
ASP A  89
ARG A  94
LYS A 184
 None
 1.06A 2q58A-4gp1A:
26.5		 2q58A-4gp1A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_B_ZOLB2_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 9 ASP A  85
ASP A  89
ARG A  94
LYS A 184
THR A 185
 None
 1.09A 2q58B-4gp1A:
26.9		 2q58B-4gp1A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QIS_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 10 LEU A  82
ASP A  85
ASP A  89
ARG A  94
LYS A 184
 None
 0.86A 2qisA-4gp1A:
28.3		 2qisA-4gp1A:
27.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_G_ASDG1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		4 / 7 LEU A  51
ALA A  71
LEU A  68
ALA A  20
 None
 1.00A 2vcvG-4gp1A:
undetectable		 2vcvG-4gp1A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_B_FUAB2002_1
(SERUM ALBUMIN)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		4 / 9 ILE A 120
ALA A 134
VAL A 137
LYS A 142
 None
 1.04A 2vufB-4gp1A:
undetectable		 2vufB-4gp1A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 11 ALA A 192
LEU A 188
ILE A  73
ILE A 141
THR A  53
 None
 1.05A 2w9sA-4gp1A:
undetectable		 2w9sA-4gp1A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_B_TOPB1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 11 ALA A 192
LEU A 188
ILE A  73
ILE A 141
THR A  53
 None
 1.03A 2w9sB-4gp1A:
undetectable		 2w9sB-4gp1A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_C_TOPC1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 10 ALA A 192
LEU A 188
ILE A  73
ILE A 141
THR A  53
 None
 1.03A 2w9sC-4gp1A:
undetectable		 2w9sC-4gp1A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YJA_B_ESTB1550_1
(ESTROGEN RECEPTOR)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 12 ALA A  56
LEU A 324
LEU A 327
ILE A 189
GLY A 214
 None
 1.10A 2yjaB-4gp1A:
undetectable		 2yjaB-4gp1A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 10 LEU A  82
ASP A  85
ASP A  89
ARG A  94
LYS A 184
THR A 185
 None
 0.96A 3ez3D-4gp1A:
27.7		 3ez3D-4gp1A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IBA_A_ZOLA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 10 ASP A  85
ASP A  89
ARG A  94
LYS A 184
THR A 185
 None
 0.96A 3ibaA-4gp1A:
28.1		 3ibaA-4gp1A:
26.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 9 ASP A  85
ASP A  89
ARG A  94
LYS A 184
THR A 185
 None
 1.10A 3ldwC-4gp1A:
27.9		 3ldwC-4gp1A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		4 / 6 LEU A 315
PHE A 213
ALA A  56
THR A 323
 None
 0.95A 3mdrA-4gp1A:
undetectable		 3mdrA-4gp1A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 11 ALA A  56
ALA A  59
VAL A 197
ALA A 190
GLY A 214
ALA A 210
 None
 1.34A 3mg0K-4gp1A:
undetectable
3mg0L-4gp1A:
undetectable		 3mg0K-4gp1A:
20.11
3mg0L-4gp1A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 12 ALA A  56
ALA A  59
VAL A 197
ALA A 190
GLY A 214
ALA A 210
 None
 1.36A 3mg0Y-4gp1A:
undetectable
3mg0Z-4gp1A:
undetectable		 3mg0Y-4gp1A:
20.11
3mg0Z-4gp1A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N45_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 11 LEU A  82
ASP A  85
ARG A  94
LYS A 184
THR A 185
 None
 0.95A 3n45F-4gp1A:
28.4		 3n45F-4gp1A:
26.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N45_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 11 LEU A  82
ASP A  85
ASP A  89
ARG A  94
LYS A 184
 None
 0.91A 3n45F-4gp1A:
28.4		 3n45F-4gp1A:
26.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N46_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 10 LEU A  82
ASP A  85
ASP A  89
ARG A  94
LYS A 184
THR A 185
 None
 1.01A 3n46F-4gp1A:
28.1		 3n46F-4gp1A:
26.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_1
(HIV-1 PROTEASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 9 ARG A  47
LEU A  21
ALA A 119
GLY A 113
ILE A  83
 None
 1.34A 3spkA-4gp1A:
undetectable		 3spkA-4gp1A:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		4 / 7 ASP A 226
GLU A 148
ASP A 244
GLU A 247
 None
 0.89A 4feuB-4gp1A:
undetectable		 4feuB-4gp1A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		4 / 8 ASP A 226
GLU A 148
ASP A 244
GLU A 247
 None
 1.08A 4feuD-4gp1A:
undetectable		 4feuD-4gp1A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		4 / 8 ASP A 226
GLU A 148
ASP A 244
GLU A 247
 None
 0.90A 4feuF-4gp1A:
undetectable		 4feuF-4gp1A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		4 / 7 ASP A 226
GLU A 148
ASP A 244
GLU A 247
 None
 1.04A 4fevB-4gp1A:
undetectable		 4fevB-4gp1A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		4 / 7 ASP A 226
GLU A 148
ASP A 244
GLU A 247
 None
 0.95A 4fevD-4gp1A:
undetectable		 4fevD-4gp1A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		4 / 7 ASP A 226
GLU A 148
ASP A 244
GLU A 247
 None
 0.92A 4fevF-4gp1A:
undetectable		 4fevF-4gp1A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		4 / 7 ASP A 226
GLU A 148
ASP A 244
GLU A 247
 None
 0.97A 4fewB-4gp1A:
undetectable		 4fewB-4gp1A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		4 / 8 ASP A 226
GLU A 148
ASP A 244
GLU A 247
 None
 0.94A 4fewD-4gp1A:
undetectable		 4fewD-4gp1A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		4 / 8 ASP A 226
GLU A 148
ASP A 244
GLU A 247
 None
 0.91A 4fewF-4gp1A:
undetectable		 4fewF-4gp1A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEX_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		4 / 7 ASP A 226
GLU A 148
ASP A 244
GLU A 247
 None
 0.93A 4fexB-4gp1A:
undetectable		 4fexB-4gp1A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		4 / 8 ASP A 226
GLU A 148
ASP A 244
GLU A 247
 None
 0.96A 4gkhB-4gp1A:
undetectable		 4gkhB-4gp1A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		4 / 8 ASP A 226
GLU A 148
ASP A 244
GLU A 247
 None
 1.02A 4gkhD-4gp1A:
undetectable		 4gkhD-4gp1A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		4 / 8 ASP A 226
GLU A 148
ASP A 244
GLU A 247
 None
 0.95A 4gkhF-4gp1A:
undetectable		 4gkhF-4gp1A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		4 / 7 ASP A 226
GLU A 148
ASP A 244
GLU A 247
 None
 0.93A 4gkhG-4gp1A:
undetectable		 4gkhG-4gp1A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_K_KANK301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		4 / 8 ASP A 226
GLU A 148
ASP A 244
GLU A 247
 None
 0.92A 4gkhC-4gp1A:
undetectable
4gkhK-4gp1A:
undetectable		 4gkhC-4gp1A:
22.85
4gkhK-4gp1A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		4 / 8 ASP A 226
GLU A 148
ASP A 244
GLU A 247
 None
 0.94A 4gkiA-4gp1A:
undetectable		 4gkiA-4gp1A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		4 / 8 ASP A 226
GLU A 148
ASP A 244
GLU A 247
 None
 0.96A 4gkiC-4gp1A:
undetectable		 4gkiC-4gp1A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		4 / 8 ASP A 226
GLU A 148
ASP A 244
GLU A 247
 None
 0.89A 4gkiE-4gp1A:
undetectable
4gkiG-4gp1A:
undetectable		 4gkiE-4gp1A:
22.85
4gkiG-4gp1A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 12 LEU A  82
LEU A 188
ILE A 120
ILE A  73
LEU A  21
 None
 1.30A 4j26B-4gp1A:
undetectable		 4j26B-4gp1A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFA_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 9 LEU A  82
ASP A  85
ASP A  89
ARG A  94
LYS A 184
 None
 0.86A 4kfaA-4gp1A:
28.0		 4kfaA-4gp1A:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		4 / 7 ARG A 117
SER A 199
VAL A 137
TRP A 195
 None
 1.46A 4kmmA-4gp1A:
undetectable		 4kmmA-4gp1A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPD_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 10 LEU A  82
ASP A  85
ASP A  89
ARG A  94
LYS A 184
THR A 185
 None
 0.95A 4kpdA-4gp1A:
28.4		 4kpdA-4gp1A:
26.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPJ_A_210A901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 9 LEU A  82
ASP A  85
ARG A  94
LYS A 184
THR A 185
 None
 0.89A 4kpjA-4gp1A:
28.0		 4kpjA-4gp1A:
26.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPJ_A_210A901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 9 LEU A  82
ASP A  85
ASP A  89
ARG A  94
LYS A 184
 None
 0.88A 4kpjA-4gp1A:
28.0		 4kpjA-4gp1A:
26.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ5_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 10 LEU A  82
ASP A  85
ARG A  94
LYS A 184
THR A 185
 None
 0.93A 4kq5A-4gp1A:
28.0		 4kq5A-4gp1A:
26.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ5_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 10 LEU A  82
ASP A  85
ASP A  89
ARG A  94
LYS A 184
 None
 0.94A 4kq5A-4gp1A:
28.0		 4kq5A-4gp1A:
26.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQS_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 10 LEU A  82
ASP A  85
ARG A  94
LYS A 184
THR A 185
 None
 0.89A 4kqsA-4gp1A:
28.3		 4kqsA-4gp1A:
26.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQS_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 10 LEU A  82
ASP A  85
ASP A  89
ARG A  94
LYS A 184
 None
 0.86A 4kqsA-4gp1A:
28.3		 4kqsA-4gp1A:
26.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 10 LEU A  82
ASP A  85
ASP A  89
ARG A  94
THR A 185
 None
 1.28A 4n9uA-4gp1A:
28.1		 4n9uA-4gp1A:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 12 LEU A  82
ASP A  85
ASP A  89
ARG A  94
THR A 185
 None
 0.61A 4ng6A-4gp1A:
28.0		 4ng6A-4gp1A:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 12 LEU A  82
ASP A  85
ASP A  89
ARG A  94
THR A 185
 None
 1.29A 4ng6A-4gp1A:
28.0		 4ng6A-4gp1A:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 10 LEU A  82
ASP A  85
ASP A  89
ARG A  94
LYS A 184
THR A 185
 None
 0.93A 4nkeA-4gp1A:
27.9		 4nkeA-4gp1A:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKF_A_210A404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 9 LEU A  82
ASP A  85
ASP A  89
ARG A  94
LYS A 184
 None
 0.88A 4nkfA-4gp1A:
28.1		 4nkfA-4gp1A:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 10 LEU A  82
ASP A  85
ARG A  94
LYS A 184
THR A 185
 None
 0.88A 4nuaA-4gp1A:
28.2		 4nuaA-4gp1A:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 10 LEU A  82
ASP A  85
ASP A  89
ARG A  94
LYS A 184
 None
 0.86A 4nuaA-4gp1A:
28.2		 4nuaA-4gp1A:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGU_A_210A405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 9 LEU A  82
ASP A  85
ARG A  94
LYS A 184
THR A 185
 None
 0.98A 4oguA-4gp1A:
27.9		 4oguA-4gp1A:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGU_A_210A405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 9 LEU A  82
ASP A  85
ASP A  89
ARG A  94
LYS A 184
 None
 0.95A 4oguA-4gp1A:
27.9		 4oguA-4gp1A:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0W_A_ZOLA501_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 11 LEU A  82
ASP A  85
ARG A  94
LYS A 184
THR A 185
 None
 0.98A 4p0wA-4gp1A:
28.3		 4p0wA-4gp1A:
27.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0W_A_ZOLA501_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 11 LEU A  82
ASP A  85
ASP A  89
ARG A  94
LYS A 184
 None
 0.98A 4p0wA-4gp1A:
28.3		 4p0wA-4gp1A:
27.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q23_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 10 LEU A  82
ASP A  85
ASP A  89
ARG A  94
LYS A 184
 None
 0.82A 4q23A-4gp1A:
27.7		 4q23A-4gp1A:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_A_RISA1404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 10 LEU A  82
ASP A  85
ARG A  94
LYS A 184
THR A 185
 None
 0.82A 4rxdA-4gp1A:
27.5		 4rxdA-4gp1A:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_A_RISA1404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 10 LEU A  82
ASP A  85
ASP A  89
ARG A  94
LYS A 184
 None
 0.82A 4rxdA-4gp1A:
27.5		 4rxdA-4gp1A:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_B_RISB1504_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 10 LEU A  82
ASP A  85
ARG A  94
LYS A 184
THR A 185
 None
 0.83A 4rxdB-4gp1A:
27.7		 4rxdB-4gp1A:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_B_RISB1504_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 10 LEU A  82
ASP A  85
ASP A  89
ARG A  94
LYS A 184
 None
 0.83A 4rxdB-4gp1A:
27.7		 4rxdB-4gp1A:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_C_RISC1600_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 10 LEU A  82
ASP A  85
ARG A  94
LYS A 184
THR A 185
 None
 0.82A 4rxdC-4gp1A:
27.8		 4rxdC-4gp1A:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_C_RISC1600_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 10 LEU A  82
ASP A  85
ASP A  89
ARG A  94
LYS A 184
 None
 0.83A 4rxdC-4gp1A:
27.8		 4rxdC-4gp1A:
24.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UMJ_A_BFQA1297_1
(GERANYLTRANSTRANSFER
ASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 8 LEU A  82
ASP A  85
ASP A  89
ARG A  94
LYS A 184
 None
 0.68A 4umjA-4gp1A:
28.8		 4umjA-4gp1A:
33.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UMJ_A_BFQA1297_1
(GERANYLTRANSTRANSFER
ASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 8 SER A  81
LEU A  82
ASP A  85
ASP A  89
ARG A  94
 None
 0.69A 4umjA-4gp1A:
28.8		 4umjA-4gp1A:
33.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UMJ_B_BFQB1294_1
(GERANYLTRANSTRANSFER
ASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 9 LEU A  82
ASP A  85
ASP A  89
ARG A  94
LYS A 184
THR A 185
 None
 0.69A 4umjB-4gp1A:
29.0		 4umjB-4gp1A:
33.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UMJ_B_BFQB1294_1
(GERANYLTRANSTRANSFER
ASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 9 SER A  81
LEU A  82
ASP A  85
ASP A  89
ARG A  94
THR A 185
 None
 0.75A 4umjB-4gp1A:
29.0		 4umjB-4gp1A:
33.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_A_SAMA1546_0
(CYSTATHIONINE
BETA-SYNTHASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 11 ASP A 225
ALA A 253
VAL A 181
THR A 185
ILE A 189
 None
 1.17A 4uuuA-4gp1A:
undetectable
4uuuB-4gp1A:
undetectable		 4uuuA-4gp1A:
21.30
4uuuB-4gp1A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_A_SAMA1546_0
(CYSTATHIONINE
BETA-SYNTHASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 11 ASP A 225
GLN A 222
VAL A 181
THR A 185
ILE A 189
 None
 1.36A 4uuuA-4gp1A:
undetectable
4uuuB-4gp1A:
undetectable		 4uuuA-4gp1A:
21.30
4uuuB-4gp1A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_B_SAMB1548_0
(CYSTATHIONINE
BETA-SYNTHASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 11 ASP A 225
ALA A 253
VAL A 181
THR A 185
ILE A 189
 None
 1.14A 4uuuB-4gp1A:
undetectable		 4uuuB-4gp1A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_B_SAMB1548_0
(CYSTATHIONINE
BETA-SYNTHASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 11 ASP A 225
GLN A 222
VAL A 181
THR A 185
ILE A 189
 None
 1.31A 4uuuB-4gp1A:
undetectable		 4uuuB-4gp1A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ5_B_ACTB404_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		3 / 3 TYR A  13
ARG A   8
LYS A  12
 None
 1.28A 4wq5B-4gp1A:
undetectable		 4wq5B-4gp1A:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJE_A_TOYA202_1
(AADB)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		4 / 8 ASP A 229
GLU A 155
ILE A 152
ASP A  89
 None
 0.87A 4xjeA-4gp1A:
undetectable		 4xjeA-4gp1A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_ACTA605_0
(SERUM ALBUMIN)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		4 / 6 HIS A  78
GLY A  45
GLU A  75
ARG A  47
 DMA  A 402 (-3.9A)
DMA  A 402 (-3.5A)
DMA  A 402 ( 4.9A)
None
 1.19A 4zbqA-4gp1A:
2.4		 4zbqA-4gp1A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		4 / 5 TYR A  24
ILE A 120
PRO A 128
THR A  53
 None
 1.15A 4ze1A-4gp1A:
undetectable		 4ze1A-4gp1A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CFT_A_51GA204_1
(AMINOGLYCOSIDE
NUCLEOTIDYLTRANSFERA
SE (2')-IA)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 9 ASP A 229
ASP A 244
GLU A 155
ILE A 152
ASP A  89
 None
 1.20A 5cftA-4gp1A:
0.9		 5cftA-4gp1A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 12 LEU A  82
ASP A  85
ARG A  94
LYS A 184
THR A 185
 None
 0.87A 5cg5A-4gp1A:
27.6		 5cg5A-4gp1A:
29.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 12 LEU A  82
ASP A  85
ASP A  89
ARG A  94
LYS A 184
 None
 0.86A 5cg5A-4gp1A:
27.6		 5cg5A-4gp1A:
29.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		6 / 12 LEU A  82
ASP A  85
ASP A  89
ARG A  94
LYS A 184
THR A 185
 None
 0.91A 5cg6A-4gp1A:
28.3		 5cg6A-4gp1A:
29.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_A_210A804_1
(FUSICOCCADIENE
SYNTHASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 9 LEU A  82
ASP A  85
ASP A  89
ARG A  94
LYS A 184
 None
 0.77A 5eroA-4gp1A:
24.4		 5eroA-4gp1A:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_C_210C804_1
(FUSICOCCADIENE
SYNTHASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 10 ASP A  85
ASP A  86
ASP A  89
ARG A  94
LYS A 184
 None
 0.78A 5eroC-4gp1A:
24.0		 5eroC-4gp1A:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 12 ALA A  56
LEU A 324
LEU A 327
ILE A 189
GLY A 214
 None
 1.01A 5gtrA-4gp1A:
2.4		 5gtrA-4gp1A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_0
(REGULATORY PROTEIN
TETR)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 12 ALA A 256
GLY A 251
GLU A 155
LEU A 274
ASP A 229
 None
 1.44A 5vlmF-4gp1A:
undetectable		 5vlmF-4gp1A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA411_0
(UNCHARACTERIZED
PROTEIN KDOO)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		3 / 3 LYS A  12
LEU A   9
ARG A   8
 None
 0.76A 5yw0A-4gp1A:
undetectable		 5yw0A-4gp1A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_1
(NS3 PROTEASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		5 / 9 LEU A 290
ARG A 276
ALA A 287
VAL A 284
ASP A 283
 None
 1.30A 6c2mB-4gp1A:
undetectable		 6c2mB-4gp1A:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_D_ZOLD401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		4 / 7 LEU A  82
ASP A  85
ASP A  89
ARG A  94
 None
 0.57A 6g31D-4gp1A:
25.5		 6g31D-4gp1A:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_E_ZOLE401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		4 / 4 LEU A  82
ASP A  85
ASP A  89
ARG A  94
 None
 0.61A 6g31E-4gp1A:
20.0		 6g31E-4gp1A:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_G_ZOLG401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		4 / 7 ASP A  85
ASP A  89
ARG A  94
LYS A 184
 None
 1.13A 6g31G-4gp1A:
24.8		 6g31G-4gp1A:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_J_ZOLJ401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4gp1 POLYPRENYL
SYNTHETASE
(Pyrobaculum
calidifontis) 		4 / 6 LEU A  82
ASP A  85
ASP A  89
ARG A  94
 None
 0.77A 6g31J-4gp1A:
26.2		 6g31J-4gp1A:
12.61