SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gpc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDS_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 4gpc HEME OXYGENASE
(Corynebacterium
diphtheriae) 		5 / 12 VAL A  63
LEU A  73
GLY A 122
PRO A 123
PHE A  68
 None
 1.48A 1fdsA-4gpcA:
undetectable		 1fdsA-4gpcA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1868_0
(FPRA)		 4gpc HEME OXYGENASE
(Corynebacterium
diphtheriae) 		3 / 3 ALA A 127
HIS A 128
VAL A 131
 None
None
BLA  A 901 (-4.4A)
 0.35A 1lqtB-4gpcA:
undetectable		 1lqtB-4gpcA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1425_0
(FPRA)		 4gpc HEME OXYGENASE
(Corynebacterium
diphtheriae) 		3 / 3 ALA A 127
HIS A 128
VAL A 131
 None
None
BLA  A 901 (-4.4A)
 0.35A 1lquB-4gpcA:
undetectable		 1lquB-4gpcA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF211_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4gpc HEME OXYGENASE
(Corynebacterium
diphtheriae) 		4 / 7 LEU A 193
LEU A   8
PHE A  68
SER A  71
 None
 0.95A 1wrlE-4gpcA:
undetectable
1wrlF-4gpcA:
undetectable		 1wrlE-4gpcA:
16.74
1wrlF-4gpcA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J1G_F_SC2F1290_1
(FICOLIN-2)		 4gpc HEME OXYGENASE
(Corynebacterium
diphtheriae) 		5 / 10 LEU A 193
LEU A   8
ASP A 187
GLU A  11
LYS A   4
 None
 1.29A 2j1gE-4gpcA:
undetectable
2j1gF-4gpcA:
undetectable		 2j1gE-4gpcA:
23.31
2j1gF-4gpcA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_1
(PROTEASE)		 4gpc HEME OXYGENASE
(Corynebacterium
diphtheriae) 		5 / 9 LEU A  87
ASP A  86
GLY A 159
ASP A 154
ILE A 143
 None
 1.05A 3ektA-4gpcA:
undetectable		 3ektA-4gpcA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4gpc HEME OXYGENASE
(Corynebacterium
diphtheriae) 		4 / 5 PRO A 123
VAL A 126
GLY A   7
LYS A   4
 None
 1.15A 3elzB-4gpcA:
undetectable		 3elzB-4gpcA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GGU_B_017B201_2
(PROTEASE)		 4gpc HEME OXYGENASE
(Corynebacterium
diphtheriae) 		5 / 9 LEU A  87
ASP A  86
GLY A 159
ASP A 154
ILE A 143
 None
 1.07A 3gguB-4gpcA:
undetectable		 3gguB-4gpcA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_A_T44A128_1
(TRANSTHYRETIN)		 4gpc HEME OXYGENASE
(Corynebacterium
diphtheriae) 		5 / 9 LEU A 193
ALA A 197
LEU A 194
SER A  15
THR A 198
 None
 1.46A 3ozkA-4gpcA:
undetectable		 3ozkA-4gpcA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_B_IMNB201_1
(TRANSTHYRETIN)		 4gpc HEME OXYGENASE
(Corynebacterium
diphtheriae) 		5 / 6 LEU A 193
ALA A 197
LEU A 194
SER A  15
THR A 198
 None
 1.49A 4ikiB-4gpcA:
undetectable		 4ikiB-4gpcA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_2
(PROTEASE)		 4gpc HEME OXYGENASE
(Corynebacterium
diphtheriae) 		5 / 9 LEU A  87
ASP A  86
GLY A 159
ASP A 154
ILE A 143
 None
 1.18A 4njtD-4gpcA:
undetectable		 4njtD-4gpcA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA845_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4gpc HEME OXYGENASE
(Corynebacterium
diphtheriae) 		4 / 8 MET A  29
PHE A  28
SER A  26
GLY A 212
 BLA  A 901 (-3.6A)
None
None
None
 0.81A 4xk8a-4gpcA:
undetectable		 4xk8a-4gpcA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZOW_A_CLMA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 4gpc HEME OXYGENASE
(Corynebacterium
diphtheriae) 		5 / 11 LEU A 113
LEU A  12
LEU A  72
LEU A  73
LEU A 180
 None
 1.06A 4zowA-4gpcA:
1.3		 4zowA-4gpcA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4gpc HEME OXYGENASE
(Corynebacterium
diphtheriae) 		4 / 6 HIS A  20
ALA A   9
LEU A 180
TYR A 133
 BLA  A 901 (-3.7A)
None
None
None
 1.09A 5igiA-4gpcA:
undetectable		 5igiA-4gpcA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_1_PQN1842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4gpc HEME OXYGENASE
(Corynebacterium
diphtheriae) 		5 / 10 SER A  66
ALA A  59
LEU A 125
GLY A 122
LEU A 169
 None
None
None
None
SO4  A 902 (-4.3A)
 1.26A 5oy01-4gpcA:
undetectable
5oy07-4gpcA:
undetectable		 5oy01-4gpcA:
15.81
5oy07-4gpcA:
11.65