SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gpd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_G_CCSG149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 4gpd APO-D-GLYCERALDEHYDE
-3-PHOSPHATE
DEHYDROGENASE
(Homarus
americanus) 		4 / 7 ASN 1 312
TYR 1 316
ASN 1 151
TYR 1 310
 None
 0.97A 1dssG-4gpd1:
48.2		 1dssG-4gpd1:
96.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_G_CCSG149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 4gpd APO-D-GLYCERALDEHYDE
-3-PHOSPHATE
DEHYDROGENASE
(Homarus
americanus) 		7 / 7 SER 1 147
THR 1 149
ASN 1 151
CYH 1 152
TYR 1 310
ASN 1 312
TYR 1 316
 None
 0.60A 1dssG-4gpd1:
48.2		 1dssG-4gpd1:
96.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_R_CCSR149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 4gpd APO-D-GLYCERALDEHYDE
-3-PHOSPHATE
DEHYDROGENASE
(Homarus
americanus) 		4 / 8 ASN 1 312
TYR 1 316
ASN 1 151
TYR 1 310
 None
 0.96A 1dssR-4gpd1:
48.1		 1dssR-4gpd1:
96.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_R_CCSR149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 4gpd APO-D-GLYCERALDEHYDE
-3-PHOSPHATE
DEHYDROGENASE
(Homarus
americanus) 		8 / 8 SER 1 147
THR 1 149
ASN 1 151
CYH 1 152
HIS 1 175
TYR 1 310
ASN 1 312
TYR 1 316
 None
 0.64A 1dssR-4gpd1:
48.1		 1dssR-4gpd1:
96.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_2
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 4gpd APO-D-GLYCERALDEHYDE
-3-PHOSPHATE
DEHYDROGENASE
(Homarus
americanus) 		4 / 4 THR 1 149
LEU 1 153
VAL 1 156
LEU 1 160
 None
 0.81A 1fbmD-4gpd1:
undetectable		 1fbmD-4gpd1:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4gpd APO-D-GLYCERALDEHYDE
-3-PHOSPHATE
DEHYDROGENASE
(Homarus
americanus) 		4 / 4 THR 1 149
LEU 1 153
VAL 1 156
LEU 1 160
 None
 0.96A 1mz9D-4gpd1:
undetectable		 1mz9D-4gpd1:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_1
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 4gpd APO-D-GLYCERALDEHYDE
-3-PHOSPHATE
DEHYDROGENASE
(Homarus
americanus) 		4 / 5 VAL 1 320
SER 1 118
ASP 1 311
GLN 1 318
 None
 1.23A 1n2xB-4gpd1:
undetectable		 1n2xB-4gpd1:
22.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DMT_C_CCSC166_0
(GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL)		 4gpd APO-D-GLYCERALDEHYDE
-3-PHOSPHATE
DEHYDROGENASE
(Homarus
americanus) 		4 / 8 ASN 1 312
TYR 1 316
ASN 1 151
TYR 1 310
 None
 1.01A 3dmtC-4gpd1:
25.2		 3dmtC-4gpd1:
55.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DMT_C_CCSC166_0
(GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL)		 4gpd APO-D-GLYCERALDEHYDE
-3-PHOSPHATE
DEHYDROGENASE
(Homarus
americanus) 		8 / 8 SER 1 147
THR 1 149
ASN 1 151
CYH 1 152
HIS 1 175
TYR 1 310
ASN 1 312
TYR 1 316
 None
 0.65A 3dmtC-4gpd1:
25.2		 3dmtC-4gpd1:
55.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 4gpd APO-D-GLYCERALDEHYDE
-3-PHOSPHATE
DEHYDROGENASE
(Homarus
americanus) 		3 / 3 LYS 1  68
SER 1   1
GLN 1  25
 None
 1.00A 3si7A-4gpd1:
undetectable		 3si7A-4gpd1:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_A_TYLA2200_1
(CREB-BINDING PROTEIN)		 4gpd APO-D-GLYCERALDEHYDE
-3-PHOSPHATE
DEHYDROGENASE
(Homarus
americanus) 		4 / 6 VAL 1  92
LEU 1 324
ILE 1 321
VAL 1  27
 None
 0.84A 4a9kA-4gpd1:
undetectable		 4a9kA-4gpd1:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA608_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 4gpd APO-D-GLYCERALDEHYDE
-3-PHOSPHATE
DEHYDROGENASE
(Homarus
americanus) 		3 / 3 GLY 1   7
THR 1  95
GLU 1  93
 None
 0.66A 6b58A-4gpd1:
2.6		 6b58A-4gpd1:
20.56