SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gpg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_1
(FTSJ)		 4gpg PROTEASE 1
(Achromobacter
lyticus) 		3 / 3 ASP A 259
ASP A  20
ASP A 135
 None
 0.73A 1eizA-4gpgA:
undetectable		 1eizA-4gpgA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_1
(FTSJ)		 4gpg PROTEASE 1
(Achromobacter
lyticus) 		3 / 3 ASP A 259
ASP A  20
ASP A 135
 None
 0.77A 1ej0A-4gpgA:
undetectable		 1ej0A-4gpgA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC8_0
(GRAMICIDIN A)		 4gpg PROTEASE 1
(Achromobacter
lyticus) 		3 / 4 VAL A 230
TRP A 247
TRP A 134
 None
 1.38A 1gmkC-4gpgA:
undetectable
1gmkD-4gpgA:
undetectable		 1gmkC-4gpgA:
4.92
1gmkD-4gpgA:
4.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_A_BEZA601_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 4gpg PROTEASE 1
(Achromobacter
lyticus) 		4 / 7 GLY A 212
ASP A 113
HIS A  57
ALA A  55
 None
 0.97A 1gxsA-4gpgA:
undetectable
1gxsB-4gpgA:
undetectable		 1gxsA-4gpgA:
21.71
1gxsB-4gpgA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_A_ACTA2001_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 4gpg PROTEASE 1
(Achromobacter
lyticus) 		4 / 5 TYR A 227
SER A 193
SER A 196
THR A 189
 None
 1.49A 1yvpA-4gpgA:
undetectable		 1yvpA-4gpgA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_B_ACTB1004_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4gpg PROTEASE 1
(Achromobacter
lyticus) 		4 / 4 HIS A 149
PRO A 150
ASN A 151
TYR A  75
 None
 1.21A 2f7aB-4gpgA:
undetectable		 2f7aB-4gpgA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_A_SALA1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4gpg PROTEASE 1
(Achromobacter
lyticus) 		4 / 8 SER A 112
ARG A 229
THR A 232
LEU A 244
 None
 1.00A 3ax7A-4gpgA:
undetectable		 3ax7A-4gpgA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4gpg PROTEASE 1
(Achromobacter
lyticus) 		3 / 3 ASP A 259
ASP A  20
ASP A 135
 None
 0.76A 3douA-4gpgA:
undetectable		 3douA-4gpgA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_0
(PCZA361.24)		 4gpg PROTEASE 1
(Achromobacter
lyticus) 		5 / 12 GLY A 102
LEU A 117
MET A  60
SER A  29
GLY A  32
 None
 1.00A 3g2oA-4gpgA:
undetectable		 3g2oA-4gpgA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		 4gpg PROTEASE 1
(Achromobacter
lyticus) 		3 / 3 PHE A 114
TYR A  51
LEU A 209
 None
 0.75A 3keeB-4gpgA:
9.8		 3keeB-4gpgA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4gpg PROTEASE 1
(Achromobacter
lyticus) 		4 / 8 SER A 112
ARG A 229
THR A 232
LEU A 244
 None
 0.95A 3ns1L-4gpgA:
undetectable		 3ns1L-4gpgA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4gpg PROTEASE 1
(Achromobacter
lyticus) 		4 / 4 PHE A 114
TYR A  51
ILE A 198
LEU A 209
 None
 1.11A 3sudA-4gpgA:
11.4		 3sudA-4gpgA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4gpg PROTEASE 1
(Achromobacter
lyticus) 		4 / 5 PHE A 114
TYR A  51
ILE A 198
LEU A 209
 None
 1.18A 3sueC-4gpgA:
10.9		 3sueC-4gpgA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_A_RITA401_2
(SECRETED ASPARTIC
PROTEASE)		 4gpg PROTEASE 1
(Achromobacter
lyticus) 		4 / 6 PRO A 201
SER A 196
TYR A 227
VAL A 180
 None
 0.82A 3tneA-4gpgA:
undetectable		 3tneA-4gpgA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_1
(PUTATIVE REGULATORY
PROTEIN)		 4gpg PROTEASE 1
(Achromobacter
lyticus) 		3 / 3 TYR A 199
MET A  50
LEU A 129
 None
 0.96A 3vw1D-4gpgA:
undetectable		 3vw1D-4gpgA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_A_CAMA424_0
(CYTOCHROME P450)		 4gpg PROTEASE 1
(Achromobacter
lyticus) 		5 / 9 TRP A 182
THR A 189
LEU A 209
GLY A 195
THR A  37
 None
 1.49A 4c9kA-4gpgA:
undetectable		 4c9kA-4gpgA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_B_CAMB424_0
(CYTOCHROME P450)		 4gpg PROTEASE 1
(Achromobacter
lyticus) 		5 / 9 TRP A 182
THR A 189
LEU A 209
GLY A 195
THR A  37
 None
 1.48A 4c9kB-4gpgA:
undetectable		 4c9kB-4gpgA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_2
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4gpg PROTEASE 1
(Achromobacter
lyticus) 		4 / 6 GLU A  14
ILE A 157
ASN A 159
GLU A 202
 None
 1.07A 4ejwB-4gpgA:
undetectable		 4ejwB-4gpgA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		 4gpg PROTEASE 1
(Achromobacter
lyticus) 		3 / 3 GLY A 192
GLU A 190
THR A 189
 None
 0.55A 4kouA-4gpgA:
undetectable		 4kouA-4gpgA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4gpg PROTEASE 1
(Achromobacter
lyticus) 		5 / 12 ALA A 218
GLN A 226
ASN A 179
GLY A 220
GLN A 181
 None
 1.19A 4r38B-4gpgA:
undetectable		 4r38B-4gpgA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4gpg PROTEASE 1
(Achromobacter
lyticus) 		5 / 12 ALA A 218
GLN A 226
ASN A 179
GLY A 220
GLN A 181
 None
 1.18A 4r38C-4gpgA:
undetectable		 4r38C-4gpgA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4gpg PROTEASE 1
(Achromobacter
lyticus) 		5 / 12 ALA A 218
GLN A 226
ASN A 179
GLY A 220
GLN A 181
 None
 1.16A 4r38D-4gpgA:
undetectable		 4r38D-4gpgA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTM_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 4gpg PROTEASE 1
(Achromobacter
lyticus) 		5 / 12 GLY A 171
GLY A 174
ALA A 173
SER A 233
GLN A 208
 None
 1.02A 4rtmA-4gpgA:
undetectable		 4rtmA-4gpgA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_A_URFA302_1
(URIDINE
PHOSPHORYLASE)		 4gpg PROTEASE 1
(Achromobacter
lyticus) 		4 / 7 THR A  85
GLY A  89
ARG A 156
ALA A  87
 None
 0.77A 4txnA-4gpgA:
undetectable		 4txnA-4gpgA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_B_URFB302_1
(URIDINE
PHOSPHORYLASE)		 4gpg PROTEASE 1
(Achromobacter
lyticus) 		4 / 7 THR A  85
GLY A  89
ARG A 156
ALA A  87
 None
 0.76A 4txnB-4gpgA:
undetectable		 4txnB-4gpgA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_C_URFC302_1
(URIDINE
PHOSPHORYLASE)		 4gpg PROTEASE 1
(Achromobacter
lyticus) 		4 / 7 THR A  85
GLY A  89
ARG A 156
ALA A  87
 None
 0.79A 4txnC-4gpgA:
undetectable		 4txnC-4gpgA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_D_URFD302_1
(URIDINE
PHOSPHORYLASE)		 4gpg PROTEASE 1
(Achromobacter
lyticus) 		4 / 7 THR A  85
GLY A  89
ARG A 156
ALA A  87
 None
 0.78A 4txnD-4gpgA:
undetectable		 4txnD-4gpgA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4gpg PROTEASE 1
(Achromobacter
lyticus) 		3 / 3 VAL A  25
ALA A  27
PHE A  52
 None
 0.85A 4z4iA-4gpgA:
undetectable		 4z4iA-4gpgA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4gpg PROTEASE 1
(Achromobacter
lyticus) 		4 / 6 SER A 242
GLY A 207
ARG A 229
GLY A 228
 None
 0.93A 5cdnC-4gpgA:
undetectable
5cdnD-4gpgA:
undetectable		 5cdnC-4gpgA:
19.13
5cdnD-4gpgA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4gpg PROTEASE 1
(Achromobacter
lyticus) 		4 / 6 SER A 242
GLY A 207
ARG A 229
GLY A 228
 None
 0.91A 5cdnT-4gpgA:
undetectable
5cdnU-4gpgA:
undetectable		 5cdnT-4gpgA:
19.13
5cdnU-4gpgA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4gpg PROTEASE 1
(Achromobacter
lyticus) 		4 / 7 ALA A 146
TYR A 199
VAL A  25
HIS A 148
 None
 1.06A 5ecnA-4gpgA:
undetectable		 5ecnA-4gpgA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4gpg PROTEASE 1
(Achromobacter
lyticus) 		3 / 3 VAL A  25
ALA A  27
PHE A  52
 None
 0.87A 5js1A-4gpgA:
undetectable		 5js1A-4gpgA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_A_MMSA511_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4gpg PROTEASE 1
(Achromobacter
lyticus) 		4 / 7 HIS A 148
LEU A 209
VAL A 188
SER A 158
 None
 0.64A 5m8rA-4gpgA:
undetectable		 5m8rA-4gpgA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4gpg PROTEASE 1
(Achromobacter
lyticus) 		4 / 8 HIS A 148
LEU A 209
VAL A 188
SER A 158
 None
 0.62A 5m8rB-4gpgA:
undetectable		 5m8rB-4gpgA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4gpg PROTEASE 1
(Achromobacter
lyticus) 		4 / 8 HIS A 148
LEU A 209
VAL A 188
SER A 158
 None
 0.63A 5m8rC-4gpgA:
undetectable		 5m8rC-4gpgA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4gpg PROTEASE 1
(Achromobacter
lyticus) 		4 / 8 HIS A 148
LEU A 209
VAL A 188
SER A 158
 None
 0.66A 5m8rD-4gpgA:
undetectable		 5m8rD-4gpgA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNW_D_GCSD302_1
(25 KDA PROTEIN
ELICITOR)		 4gpg PROTEASE 1
(Achromobacter
lyticus) 		4 / 7 GLY A 228
HIS A 177
HIS A  57
ASP A 113
 None
 0.80A 5nnwD-4gpgA:
undetectable		 5nnwD-4gpgA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NO9_D_95ZD302_1
(25 KDA PROTEIN
ELICITOR)		 4gpg PROTEASE 1
(Achromobacter
lyticus) 		4 / 7 GLY A 228
HIS A 177
HIS A  57
ASP A 113
 None
 0.81A 5no9D-4gpgA:
undetectable		 5no9D-4gpgA:
13.43