SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gpn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		 4gpn 6-PHOSPHO-BETA-D-GLU
COSIDASE
(Streptococcus
mutans) 		4 / 7 TYR A 398
HIS A 402
LEU A 356
TYR A 313
 None
None
None
6GB  A 501 (-4.2A)
 1.12A 1tuvA-4gpnA:
undetectable		 1tuvA-4gpnA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B82_A_ADNA1001_1
(CLASS B ACID
PHOSPHATASE)		 4gpn 6-PHOSPHO-BETA-D-GLU
COSIDASE
(Streptococcus
mutans) 		5 / 10 PHE A 161
LYS A 165
LEU A 232
GLY A 235
ASP A 306
 None
 1.28A 2b82A-4gpnA:
1.9		 2b82A-4gpnA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4gpn 6-PHOSPHO-BETA-D-GLU
COSIDASE
(Streptococcus
mutans) 		4 / 7 TYR A 264
TYR A 358
TYR A 367
ILE A 308
 None
 1.31A 2ph9A-4gpnA:
undetectable
2ph9B-4gpnA:
undetectable		 2ph9A-4gpnA:
18.63
2ph9B-4gpnA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4gpn 6-PHOSPHO-BETA-D-GLU
COSIDASE
(Streptococcus
mutans) 		4 / 8 PHE A 266
VAL A 238
TYR A 330
ASN A 192
 None
 1.06A 2wekA-4gpnA:
undetectable		 2wekA-4gpnA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4gpn 6-PHOSPHO-BETA-D-GLU
COSIDASE
(Streptococcus
mutans) 		4 / 8 PHE A 266
VAL A 238
TYR A 330
ASN A 192
 None
 1.10A 2wekB-4gpnA:
undetectable		 2wekB-4gpnA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 4gpn 6-PHOSPHO-BETA-D-GLU
COSIDASE
(Streptococcus
mutans) 		3 / 3 ASP A 111
PHE A 114
LEU A 118
 None
 0.50A 2zi9A-4gpnA:
undetectable		 2zi9A-4gpnA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_1
(N,N-DIMETHYLTRANSFER
ASE)		 4gpn 6-PHOSPHO-BETA-D-GLU
COSIDASE
(Streptococcus
mutans) 		3 / 3 TYR A 164
GLU A  20
ASP A  64
 None
 0.84A 3bxoA-4gpnA:
undetectable		 3bxoA-4gpnA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_1
(N,N-DIMETHYLTRANSFER
ASE)		 4gpn 6-PHOSPHO-BETA-D-GLU
COSIDASE
(Streptococcus
mutans) 		3 / 3 TYR A 164
GLU A  20
ASP A  64
 None
 0.83A 3bxoB-4gpnA:
undetectable		 3bxoB-4gpnA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_2
(GLUCOCORTICOID
RECEPTOR 2)		 4gpn 6-PHOSPHO-BETA-D-GLU
COSIDASE
(Streptococcus
mutans) 		3 / 3 MET A  36
MET A 436
PHE A 131
 None
None
6GB  A 501 ( 4.9A)
 1.35A 3gn8A-4gpnA:
undetectable		 3gn8A-4gpnA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSK_B_ACTB901_0
(PYRANOSE 2-OXIDASE)		 4gpn 6-PHOSPHO-BETA-D-GLU
COSIDASE
(Streptococcus
mutans) 		4 / 6 SER A 311
PHE A 131
HIS A 130
ASN A 175
 None
6GB  A 501 ( 4.9A)
6GB  A 501 (-4.3A)
6GB  A 501 (-3.6A)
 1.30A 3lskB-4gpnA:
undetectable		 3lskB-4gpnA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSK_D_ACTD901_0
(PYRANOSE 2-OXIDASE)		 4gpn 6-PHOSPHO-BETA-D-GLU
COSIDASE
(Streptococcus
mutans) 		4 / 6 SER A 311
PHE A 131
HIS A 130
ASN A 175
 None
6GB  A 501 ( 4.9A)
6GB  A 501 (-4.3A)
6GB  A 501 (-3.6A)
 1.30A 3lskD-4gpnA:
undetectable		 3lskD-4gpnA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_B_9PLB1_1
(CYTOCHROME P450 2A13)		 4gpn 6-PHOSPHO-BETA-D-GLU
COSIDASE
(Streptococcus
mutans) 		4 / 6 PHE A 174
ASN A 192
PHE A 144
ALA A 210
 None
 1.08A 3t3sB-4gpnA:
undetectable		 3t3sB-4gpnA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_1
(NEURAMINIDASE)		 4gpn 6-PHOSPHO-BETA-D-GLU
COSIDASE
(Streptococcus
mutans) 		3 / 3 ARG A 220
ASP A 151
ARG A 295
 None
 1.00A 4mx0A-4gpnA:
undetectable		 4mx0A-4gpnA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_2
(ESTROGEN RECEPTOR)		 4gpn 6-PHOSPHO-BETA-D-GLU
COSIDASE
(Streptococcus
mutans) 		4 / 6 ASP A  34
GLU A 132
HIS A  67
PRO A  58
 None
 0.99A 4xi3C-4gpnA:
undetectable		 4xi3C-4gpnA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4gpn 6-PHOSPHO-BETA-D-GLU
COSIDASE
(Streptococcus
mutans) 		5 / 12 ILE A 234
GLY A 225
ALA A 217
SER A  87
ILE A  88
 None
 1.21A 5igvA-4gpnA:
undetectable		 5igvA-4gpnA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_0
(NS3 PROTEASE)		 4gpn 6-PHOSPHO-BETA-D-GLU
COSIDASE
(Streptococcus
mutans) 		5 / 12 GLY A 225
VAL A 159
LEU A 300
GLY A 303
ALA A 217
 None
 0.98A 6c2mA-4gpnA:
undetectable		 6c2mA-4gpnA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_B_LLLB301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4gpn 6-PHOSPHO-BETA-D-GLU
COSIDASE
(Streptococcus
mutans) 		4 / 7 ARG A 263
TYR A 330
GLU A 332
GLU A 176
 None
None
None
6GB  A 501 (-3.0A)
 1.23A 6mn5B-4gpnA:
undetectable		 6mn5B-4gpnA:
10.32