SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gpr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AW1_A_COXA264_1
(CARBONIC ANHYDRASE
II)		 4gpr UBIQUITIN-CONJUGATIN
G ENZYME FAMILY
PROTEIN
(Entamoeba
histolytica) 		5 / 12 ILE A  84
VAL A  67
LEU A  52
VAL A  54
LEU A 103
 None
 0.96A 2aw1A-4gprA:
undetectable		 2aw1A-4gprA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OMB_A_IPHA2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 4gpr UBIQUITIN-CONJUGATIN
G ENZYME FAMILY
PROTEIN
(Entamoeba
histolytica) 		4 / 5 HIS A  75
PRO A 113
TYR A  45
PRO A  40
 None
 1.50A 2ombA-4gprA:
undetectable
2ombB-4gprA:
undetectable		 2ombA-4gprA:
23.18
2ombB-4gprA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_0
(NEURAMINIDASE)		 4gpr UBIQUITIN-CONJUGATIN
G ENZYME FAMILY
PROTEIN
(Entamoeba
histolytica) 		5 / 12 GLU A   9
LEU A  99
ARG A 101
SER A 100
GLU A  12
 None
 1.28A 4mx0A-4gprA:
undetectable		 4mx0A-4gprA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XIW_G_AZMG402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 4gpr UBIQUITIN-CONJUGATIN
G ENZYME FAMILY
PROTEIN
(Entamoeba
histolytica) 		5 / 12 GLU A   9
VAL A  67
LEU A  52
VAL A  54
LEU A 103
 None
 0.85A 4xiwG-4gprA:
undetectable		 4xiwG-4gprA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_2
(ESTROGEN RECEPTOR)		 4gpr UBIQUITIN-CONJUGATIN
G ENZYME FAMILY
PROTEIN
(Entamoeba
histolytica) 		4 / 5 LEU A  52
LEU A  89
PHE A  69
LEU A 109
 None
 1.04A 5gtrA-4gprA:
undetectable		 5gtrA-4gprA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 4gpr UBIQUITIN-CONJUGATIN
G ENZYME FAMILY
PROTEIN
(Entamoeba
histolytica) 		5 / 11 VAL A  73
PHE A  69
THR A  71
ILE A 106
LEU A 110
 None
 1.27A 6h1lB-4gprA:
undetectable		 6h1lB-4gprA:
16.04