SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gps'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		 4gps KLLA0E02245P
(Kluyveromyces
lactis) 		6 / 11 PHE A 361
ILE A 360
LEU A 300
VAL A 382
MET A 182
LEU A 140
 None
 1.23A 1dtlA-4gpsA:
undetectable		 1dtlA-4gpsA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_2
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4gps KLLA0E02245P
(Kluyveromyces
lactis) 		3 / 3 ASN A 284
ILE A 333
MET A 294
 None
 0.67A 2h42C-4gpsA:
undetectable		 2h42C-4gpsA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4gps KLLA0E02245P
(Kluyveromyces
lactis) 		5 / 12 VAL A 382
PHE A 158
ILE A 360
ILE A 253
LEU A 255
 None
 1.00A 3w67D-4gpsA:
undetectable		 3w67D-4gpsA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4gps KLLA0E02245P
(Kluyveromyces
lactis) 		4 / 6 ILE A 190
CYH A  44
LEU A  42
ILE A 392
 None
 0.89A 4asdA-4gpsA:
undetectable		 4asdA-4gpsA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_0
(WBDD)		 4gps KLLA0E02245P
(Kluyveromyces
lactis) 		5 / 12 ASN A 189
ILE A 257
LEU A 249
SER A 248
HIS A 246
 None
 0.98A 4azvA-4gpsA:
undetectable		 4azvA-4gpsA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_1
(DIHYDROFOLATE
REDUCTASE)		 4gps KLLA0E02245P
(Kluyveromyces
lactis) 		5 / 12 ILE A 168
PHE A 361
LEU A  63
LEU A 255
ILE A 165
 None
 1.00A 4m2xA-4gpsA:
undetectable		 4m2xA-4gpsA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M35_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4gps KLLA0E02245P
(Kluyveromyces
lactis) 		3 / 3 MET A 294
GLN A 297
ARG A 293
 None
CIT  A 501 (-3.6A)
CIT  A 501 (-3.0A)
 1.07A 5m35B-4gpsA:
undetectable		 5m35B-4gpsA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M36_A_BEZA303_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4gps KLLA0E02245P
(Kluyveromyces
lactis) 		3 / 3 MET A 294
GLN A 297
ARG A 293
 None
CIT  A 501 (-3.6A)
CIT  A 501 (-3.0A)
 1.07A 5m36A-4gpsA:
undetectable		 5m36A-4gpsA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUE_A_VIVA302_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4gps KLLA0E02245P
(Kluyveromyces
lactis) 		5 / 12 ILE A 192
VAL A 382
PHE A 158
ILE A 360
ILE A 253
 None
 0.99A 5mueA-4gpsA:
undetectable		 5mueA-4gpsA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_B_ADNB401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 4gps KLLA0E02245P
(Kluyveromyces
lactis) 		5 / 8 GLY A 309
LYS A 322
ALA A 323
PHE A 310
PHE A 280
 None
 1.44A 5mvsB-4gpsA:
undetectable		 5mvsB-4gpsA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_B_OAQB302_0
(SULFOTRANSFERASE)		 4gps KLLA0E02245P
(Kluyveromyces
lactis) 		5 / 12 PRO A 302
ILE A 165
LEU A 301
VAL A 245
THR A 157
 None
 1.31A 5tiwB-4gpsA:
undetectable		 5tiwB-4gpsA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FN9_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4gps KLLA0E02245P
(Kluyveromyces
lactis) 		3 / 3 MET A 294
GLN A 297
ARG A 293
 None
CIT  A 501 (-3.6A)
CIT  A 501 (-3.0A)
 1.05A 6fn9A-4gpsA:
undetectable		 6fn9A-4gpsA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNA_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4gps KLLA0E02245P
(Kluyveromyces
lactis) 		3 / 3 MET A 294
GLN A 297
ARG A 293
 None
CIT  A 501 (-3.6A)
CIT  A 501 (-3.0A)
 1.04A 6fnaB-4gpsA:
undetectable		 6fnaB-4gpsA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNB_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4gps KLLA0E02245P
(Kluyveromyces
lactis) 		3 / 3 MET A 294
GLN A 297
ARG A 293
 None
CIT  A 501 (-3.6A)
CIT  A 501 (-3.0A)
 1.07A 6fnbA-4gpsA:
undetectable		 6fnbA-4gpsA:
18.90