SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gpv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_C_DESC129_1
(TRANSTHYRETIN)		 4gpv PUTATIVE CELL
ADHESION PROTEIN
(Bacteroides
eggerthii) 		4 / 6 LEU A 282
ALA A 202
LEU A 204
SER A 244
 None
 0.93A 1tz8C-4gpvA:
4.0
1tz8D-4gpvA:
4.1		 1tz8C-4gpvA:
17.63
1tz8D-4gpvA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WU8_C_ADNC502_1
(HYPOTHETICAL PROTEIN
PH0463)		 4gpv PUTATIVE CELL
ADHESION PROTEIN
(Bacteroides
eggerthii) 		4 / 7 ASN A  90
TYR A  69
ASN A  68
VAL A 107
 None
 1.01A 1wu8A-4gpvA:
undetectable
1wu8C-4gpvA:
undetectable		 1wu8A-4gpvA:
22.38
1wu8C-4gpvA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1217_1
(LIPOPROTEIN LPPX)		 4gpv PUTATIVE CELL
ADHESION PROTEIN
(Bacteroides
eggerthii) 		4 / 4 VAL A 343
LEU A 204
ILE A 179
LEU A 181
 None
 1.00A 2byoA-4gpvA:
undetectable		 2byoA-4gpvA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4gpv PUTATIVE CELL
ADHESION PROTEIN
(Bacteroides
eggerthii) 		5 / 11 ILE A 312
ALA A 207
ILE A 179
ILE A 301
PHE A 303
 None
 0.93A 2w9sA-4gpvA:
undetectable		 2w9sA-4gpvA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_B_TOPB1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4gpv PUTATIVE CELL
ADHESION PROTEIN
(Bacteroides
eggerthii) 		5 / 11 ILE A 312
ALA A 207
ILE A 179
ILE A 301
PHE A 303
 None
 0.96A 2w9sB-4gpvA:
undetectable		 2w9sB-4gpvA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_C_TOPC1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4gpv PUTATIVE CELL
ADHESION PROTEIN
(Bacteroides
eggerthii) 		5 / 10 ILE A 312
ALA A 207
ILE A 179
ILE A 301
PHE A 303
 None
 0.96A 2w9sC-4gpvA:
undetectable		 2w9sC-4gpvA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA302_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 4gpv PUTATIVE CELL
ADHESION PROTEIN
(Bacteroides
eggerthii) 		5 / 6 THR A 359
LEU A 172
GLY A 154
ALA A  64
PRO A 361
 None
 1.23A 3huoA-4gpvA:
undetectable		 3huoA-4gpvA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_B_DX2B271_1
(PTERIDINE REDUCTASE
1)		 4gpv PUTATIVE CELL
ADHESION PROTEIN
(Bacteroides
eggerthii) 		4 / 8 SER A 248
PHE A 230
ASP A 200
PRO A 339
 None
 0.97A 3jq7B-4gpvA:
undetectable		 3jq7B-4gpvA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_B_ACTB401_0
(UNCHARACTERIZED
PROTEIN)		 4gpv PUTATIVE CELL
ADHESION PROTEIN
(Bacteroides
eggerthii) 		4 / 5 VAL A 108
LEU A 128
VAL A 122
PHE A 119
 None
 0.89A 4lb0B-4gpvA:
undetectable		 4lb0B-4gpvA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_H_BEZH201_0
(NS3 PROTEASE)		 4gpv PUTATIVE CELL
ADHESION PROTEIN
(Bacteroides
eggerthii) 		4 / 5 SER A  88
TYR A  69
GLY A  87
TYR A  85
 None
 1.40A 5yodH-4gpvA:
undetectable		 5yodH-4gpvA:
21.10