SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gq1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPK_A_ACAA80_1
(PLASMINOGEN)		 4gq1 NUP37
(Schizosaccharomy
ces
pombe) 		4 / 6 PRO A 233
ASP A 214
ASN A 199
TYR A 182
 None
 1.18A 1hpkA-4gq1A:
undetectable		 1hpkA-4gq1A:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_F_CLMF1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4gq1 NUP37
(Schizosaccharomy
ces
pombe) 		5 / 7 PRO A  70
PRO A  17
THR A  42
ILE A  35
GLY A  36
 None
 1.48A 1usqF-4gq1A:
undetectable		 1usqF-4gq1A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 4gq1 NUP37
(Schizosaccharomy
ces
pombe) 		4 / 8 VAL A 381
THR A  58
TYR A  44
LEU A  33
 None
 1.00A 1z2bB-4gq1A:
undetectable		 1z2bB-4gq1A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_B_STRB302_1
(MINERALOCORTICOID
RECEPTOR)		 4gq1 NUP37
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A  74
LEU A 114
GLN A 156
SER A  79
THR A  21
 None
 1.37A 2aa5B-4gq1A:
undetectable		 2aa5B-4gq1A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_E_CLME1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4gq1 NUP37
(Schizosaccharomy
ces
pombe) 		5 / 7 PRO A  70
PRO A  17
THR A  42
ILE A  35
GLY A  36
 None
 1.50A 2jkjE-4gq1A:
undetectable		 2jkjE-4gq1A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4gq1 NUP37
(Schizosaccharomy
ces
pombe) 		5 / 7 PRO A  70
PRO A  17
THR A  42
ILE A  35
GLY A  36
 None
 1.49A 2jklE-4gq1A:
undetectable		 2jklE-4gq1A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 4gq1 NUP37
(Schizosaccharomy
ces
pombe) 		6 / 12 ILE A 115
THR A 117
LEU A 103
CYH A 105
LEU A  69
THR A  71
 None
 1.36A 2jn3A-4gq1A:
2.0		 2jn3A-4gq1A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA131_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 4gq1 NUP37
(Schizosaccharomy
ces
pombe) 		5 / 12 ILE A 115
THR A 117
LEU A 103
CYH A 105
THR A  71
 None
 1.06A 2qo5A-4gq1A:
2.8		 2qo5A-4gq1A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_C_SALC1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4gq1 NUP37
(Schizosaccharomy
ces
pombe) 		4 / 7 ILE A 311
GLY A 310
PHE A 330
ILE A 343
 None
 0.82A 2y7wC-4gq1A:
undetectable		 2y7wC-4gq1A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4gq1 NUP37
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A  74
LEU A 103
ILE A  65
THR A 117
HIS A  37
 None
 1.01A 3gcsA-4gq1A:
undetectable		 3gcsA-4gq1A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SM2_A_478A126_2
(GAG-PRO-POL
POLYPROTEIN)		 4gq1 NUP37
(Schizosaccharomy
ces
pombe) 		5 / 11 ALA A 159
VAL A 203
GLY A 181
ALA A 180
LEU A 201
 None
 0.95A 3sm2B-4gq1A:
undetectable		 3sm2B-4gq1A:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_A_PXLA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4gq1 NUP37
(Schizosaccharomy
ces
pombe) 		4 / 7 GLY A 204
GLY A 188
VAL A 191
HIS A 134
 None
 0.75A 4c5nA-4gq1A:
undetectable		 4c5nA-4gq1A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_C_PXLC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4gq1 NUP37
(Schizosaccharomy
ces
pombe) 		4 / 8 GLY A 204
GLY A 188
VAL A 191
HIS A 134
 None
 0.81A 4c5nC-4gq1A:
undetectable		 4c5nC-4gq1A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4gq1 NUP37
(Schizosaccharomy
ces
pombe) 		4 / 6 ILE A 158
VAL A 146
SER A  75
ASP A 214
 None
 1.16A 4iaqA-4gq1A:
undetectable		 4iaqA-4gq1A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_E_TMQE202_1
(DIHYDROFOLATE
REDUCTASE)		 4gq1 NUP37
(Schizosaccharomy
ces
pombe) 		5 / 12 ILE A 116
ASP A 142
ILE A 143
LEU A  74
ILE A 115
 None
 1.04A 4m2xE-4gq1A:
undetectable		 4m2xE-4gq1A:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_A_ACTA603_0
(CHOLINE OXIDASE)		 4gq1 NUP37
(Schizosaccharomy
ces
pombe) 		3 / 3 ARG A 385
HIS A 372
SER A   5
 None
 0.99A 4mjwA-4gq1A:
undetectable
4mjwB-4gq1A:
undetectable		 4mjwA-4gq1A:
19.89
4mjwB-4gq1A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_B_ACTB603_0
(CHOLINE OXIDASE)		 4gq1 NUP37
(Schizosaccharomy
ces
pombe) 		3 / 3 SER A   5
ARG A 385
HIS A 372
 None
 1.02A 4mjwA-4gq1A:
undetectable
4mjwB-4gq1A:
undetectable		 4mjwA-4gq1A:
19.89
4mjwB-4gq1A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4gq1 NUP37
(Schizosaccharomy
ces
pombe) 		4 / 6 GLU A  61
THR A  64
THR A  20
LEU A  11
 None
 1.13A 4pgfA-4gq1A:
undetectable		 4pgfA-4gq1A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4gq1 NUP37
(Schizosaccharomy
ces
pombe) 		3 / 3 ALA A  34
TYR A  44
PRO A  17
 None
 0.67A 4zdyA-4gq1A:
undetectable		 4zdyA-4gq1A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE0_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4gq1 NUP37
(Schizosaccharomy
ces
pombe) 		5 / 9 THR A  64
GLY A  36
THR A  20
LEU A  33
LEU A  59
 None
 1.20A 4ze0A-4gq1A:
undetectable		 4ze0A-4gq1A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		 4gq1 NUP37
(Schizosaccharomy
ces
pombe) 		4 / 7 ARG A 211
VAL A 203
LEU A 184
SER A 185
 SO4  A 401 (-3.1A)
None
None
SO4  A 401 (-3.6A)
 1.08A 4zphA-4gq1A:
undetectable
4zphB-4gq1A:
undetectable		 4zphA-4gq1A:
23.01
4zphB-4gq1A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_2
(CYP51 VARIANT1)		 4gq1 NUP37
(Schizosaccharomy
ces
pombe) 		3 / 3 PRO A 195
LEU A 283
SER A 264
 None
 0.83A 5fsaB-4gq1A:
undetectable		 5fsaB-4gq1A:
22.05