SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gq2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB6_0
(GRAMICIDIN A)		 4gq2 NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		3 / 3 TRP M  25
ALA M  28
VAL M  26
 None
 0.92A 1bdwA-4gq2M:
undetectable
1bdwB-4gq2M:
undetectable		 1bdwA-4gq2M:
2.30
1bdwB-4gq2M:
2.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_1
(DIHYDROFOLATE
REDUCTASE)		 4gq2 NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		3 / 3 GLU M 434
ILE M 433
ARG M 679
 None
 0.55A 1cd2A-4gq2M:
undetectable		 1cd2A-4gq2M:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_1
(TRANSTHYRETIN)		 4gq2 NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		4 / 7 LEU M 287
LEU M 299
SER M 308
SER M 310
 None
 0.95A 1dvxA-4gq2M:
0.4		 1dvxA-4gq2M:
7.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4gq2 NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		4 / 6 VAL M  26
VAL M 102
ILE M 128
ARG M  81
 None
 1.12A 1iepA-4gq2M:
undetectable		 1iepA-4gq2M:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_1
(RETINOIC ACID
RECEPTOR, BETA)		 4gq2 NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU M 652
ILE M 649
ILE M 653
SER M 658
LEU M 698
 None
 1.07A 1xdkB-4gq2M:
undetectable		 1xdkB-4gq2M:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_K_BEZK4387_0
(CES1 PROTEIN)		 4gq2 NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		3 / 3 TRP M 834
LEU M 835
LYS M 845
 None
 1.44A 1yajK-4gq2M:
3.6		 1yajK-4gq2M:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4gq2 NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		4 / 7 ILE M 548
PHE M 802
LEU M 798
ILE M 692
 None
 0.80A 1yc2E-4gq2M:
undetectable		 1yc2E-4gq2M:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_D_IMND476_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 4gq2 NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		5 / 12 ILE M 426
VAL M 509
SER M 435
ILE M 433
VAL M 470
 None
 1.17A 1z9hD-4gq2M:
undetectable		 1z9hD-4gq2M:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_A_SAMA1500_0
(ASPARTOKINASE)		 4gq2 NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		4 / 8 ILE M 238
SER M 253
SER M 275
LEU M 279
 None
 0.92A 2cdqA-4gq2M:
undetectable		 2cdqA-4gq2M:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_A_SAMA1500_0
(ASPARTOKINASE)		 4gq2 NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		4 / 8 SER M 253
ASP M 255
SER M 275
LEU M 279
 None
 0.75A 2cdqA-4gq2M:
undetectable		 2cdqA-4gq2M:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_B_SAMB1500_0
(ASPARTOKINASE)		 4gq2 NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		4 / 7 SER M 253
ASP M 255
SER M 275
LEU M 279
 None
 0.81A 2cdqB-4gq2M:
undetectable		 2cdqB-4gq2M:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4gq2 NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		5 / 12 SER M 590
PHE M 406
ARG M 496
THR M 411
ILE M 418
 None
 1.40A 2fj1A-4gq2M:
1.4		 2fj1A-4gq2M:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_1
(ESTROGEN RECEPTOR)		 4gq2 NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		5 / 12 THR M 865
LEU M 895
LEU M 894
ILE M 885
LEU M 902
 None
 1.15A 2qxsA-4gq2M:
undetectable		 2qxsA-4gq2M:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TCT_A_CTCA222_0
(TETRACYCLINE
REPRESSOR)		 4gq2 NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		5 / 12 SER M 590
PHE M 406
ARG M 496
THR M 411
ILE M 418
 None
 1.50A 2tctA-4gq2M:
1.3		 2tctA-4gq2M:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		 4gq2 NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		4 / 7 LEU M 346
GLU M 518
LEU M 520
TYR M 286
 None
 1.19A 2w8yA-4gq2M:
undetectable		 2w8yA-4gq2M:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9G_A_TOPA1159_1
(DIHYDROFOLATE
REDUCTASE)		 4gq2 NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		5 / 10 LEU M 423
VAL M 470
SER M 432
ILE M 433
PHE M 427
 None
 1.13A 2w9gA-4gq2M:
undetectable		 2w9gA-4gq2M:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9H_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE)		 4gq2 NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		5 / 10 LEU M 423
VAL M 470
SER M 432
ILE M 433
PHE M 427
 None
 1.12A 2w9hA-4gq2M:
undetectable		 2w9hA-4gq2M:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_C_DVAC8_0
(GRAMICIDIN A)		 4gq2 NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		3 / 3 VAL M 409
TRP M 502
TRP M 422
 None
 1.50A 2xdcC-4gq2M:
undetectable
2xdcD-4gq2M:
undetectable		 2xdcC-4gq2M:
2.30
2xdcD-4gq2M:
2.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGQ_A_PCFA1275_0
(WNT INHIBITORY
FACTOR 1)		 4gq2 NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		5 / 12 ILE M 463
LEU M 741
ILE M 433
PHE M 505
VAL M 509
 None
 0.96A 2ygqA-4gq2M:
undetectable		 2ygqA-4gq2M:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)		 4gq2 NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		5 / 11 LEU M 730
ILE M 801
PHE M 773
VAL M 816
LEU M 819
 None
 1.32A 3a9eB-4gq2M:
undetectable		 3a9eB-4gq2M:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_F_H3PF552_1
(GLUTAMATE
DEHYDROGENASE)		 4gq2 NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		4 / 7 ILE M 636
LYS M 713
ILE M 702
TYR M 619
 None
 1.14A 3eteD-4gq2M:
undetectable
3eteF-4gq2M:
undetectable		 3eteD-4gq2M:
19.96
3eteF-4gq2M:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRB_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 4gq2 NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		5 / 11 LEU M 423
VAL M 470
SER M 432
ILE M 433
PHE M 427
 None
 1.09A 3frbX-4gq2M:
undetectable		 3frbX-4gq2M:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_1
(O-METHYLTRANSFERASE)		 4gq2 NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		4 / 4 ASP M 727
SER M 691
PHE M 688
SER M 799
 None
 1.49A 3i5uA-4gq2M:
0.0		 3i5uA-4gq2M:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_A_VIBA223_1
(THIAMINE
PYROPHOSPHOKINASE)		 4gq2 NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		4 / 7 LEU M 819
LEU M 742
SER M 738
ASN M 737
 None
 1.04A 3lm8A-4gq2M:
undetectable
3lm8C-4gq2M:
undetectable		 3lm8A-4gq2M:
13.24
3lm8C-4gq2M:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)		 4gq2 NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		4 / 8 ILE M 576
SER M 569
SER M 651
GLY M 573
 None
 0.91A 3lslA-4gq2M:
undetectable
3lslD-4gq2M:
undetectable		 3lslA-4gq2M:
14.81
3lslD-4gq2M:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 4gq2 NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		5 / 9 LEU M 831
LEU M 819
ILE M 840
GLU M 817
PHE M 733
 None
 1.42A 3tmzA-4gq2M:
undetectable		 3tmzA-4gq2M:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 4gq2 NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		4 / 5 LEU M 730
LEU M 734
LEU M 798
SER M 799
 None
 0.94A 3vhuA-4gq2M:
undetectable		 3vhuA-4gq2M:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_D_NCTD501_1
(CYTOCHROME P450 2A6)		 4gq2 NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		4 / 7 GLY M 694
ILE M 595
LEU M 599
PHE M 618
 None
 0.77A 4ejjD-4gq2M:
undetectable		 4ejjD-4gq2M:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 4gq2 NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		5 / 12 SER M 691
GLU M 693
ILE M 692
TRP M 728
LEU M 685
 None
 1.18A 4foxD-4gq2M:
undetectable		 4foxD-4gq2M:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 4gq2 NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU M 699
LEU M 615
LEU M 725
ILE M 649
ILE M 653
 None
 1.05A 4j24B-4gq2M:
undetectable		 4j24B-4gq2M:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_2
(ADENOSINE KINASE)		 4gq2 NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		4 / 4 LEU M 698
SER M 582
LEU M 577
LEU M 639
 None
 1.11A 4n09A-4gq2M:
undetectable		 4n09A-4gq2M:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_2
(ADENOSINE KINASE)		 4gq2 NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		4 / 5 ASN M 836
LEU M 835
LEU M 815
ASN M 737
 None
 1.16A 4n09C-4gq2M:
undetectable		 4n09C-4gq2M:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4gq2 NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		5 / 12 VAL M 731
SER M 732
PHE M 802
TRP M 834
VAL M 603
 None
 1.34A 4nc3A-4gq2M:
2.1		 4nc3A-4gq2M:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 4gq2 NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		5 / 12 GLU M 736
ASN M 737
ILE M 848
LEU M 844
GLY M 833
 None
 0.99A 4o1eA-4gq2M:
undetectable		 4o1eA-4gq2M:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_B_C2FB4000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 4gq2 NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		5 / 12 GLU M 736
ASN M 737
ILE M 848
LEU M 844
GLY M 833
 None
 1.00A 4o1eB-4gq2M:
undetectable		 4o1eB-4gq2M:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_A_BRLA501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4gq2 NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		4 / 5 GLY M 580
LEU M 559
LEU M 656
LEU M 642
 None
 0.83A 4o8fA-4gq2M:
undetectable		 4o8fA-4gq2M:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP9_A_ASCA501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 4gq2 NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		5 / 12 THR M 531
HIS M 291
ILE M 352
ALA M 298
ILE M 522
 None
 1.47A 4rp9A-4gq2M:
undetectable		 4rp9A-4gq2M:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2G_B_CTCB222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4gq2 NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		5 / 12 SER M 590
PHE M 406
ARG M 496
THR M 411
ILE M 418
 None
 1.39A 4v2gB-4gq2M:
undetectable		 4v2gB-4gq2M:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNU_A_BEZA319_0
(SHKAI2IB)		 4gq2 NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		4 / 5 GLN M 207
ILE M 196
ILE M 195
TYR M 205
 None
 1.28A 5dnuA-4gq2M:
undetectable		 5dnuA-4gq2M:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_2
(CYP51 VARIANT1)		 4gq2 NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		3 / 3 PRO M 107
ILE M 127
SER M  33
 None
 0.79A 5fsaA-4gq2M:
0.9		 5fsaA-4gq2M:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_C_IPHC101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 4gq2 NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		4 / 6 CYH M 184
LEU M 261
HIS M 208
LEU M 192
 None
 1.18A 5hpuC-4gq2M:
undetectable
5hpuD-4gq2M:
undetectable		 5hpuC-4gq2M:
4.22
5hpuD-4gq2M:
2.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_2
(ENDO-1,4-BETA-XYLANA
SE A)		 4gq2 NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		3 / 3 ARG M 581
PRO M 555
TYR M 574
 None
 1.00A 5tzoB-4gq2M:
undetectable		 5tzoB-4gq2M:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_0
(REGULATORY PROTEIN
TETR)		 4gq2 NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		5 / 12 ALA M 678
LEU M 673
VAL M   9
ASP M  87
PHE M  16
 None
 1.47A 5vlmD-4gq2M:
0.5		 5vlmD-4gq2M:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4gq2 NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		5 / 10 LEU M 252
SER M 239
LEU M 174
ASP M 113
SER M 283
 None
 1.27A 6dlzB-4gq2M:
2.5
6dlzC-4gq2M:
5.5		 6dlzB-4gq2M:
6.47
6dlzC-4gq2M:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4gq2 NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		5 / 11 SER M 283
LEU M 252
SER M 239
LEU M 174
ASP M 113
 None
 1.26A 6dlzA-4gq2M:
5.5
6dlzD-4gq2M:
2.6		 6dlzA-4gq2M:
6.47
6dlzD-4gq2M:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4gq2 NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		5 / 10 LEU M 252
SER M 239
LEU M 174
ASP M 113
SER M 283
 None
 1.26A 6dm1B-4gq2M:
2.6
6dm1C-4gq2M:
5.5		 6dm1B-4gq2M:
6.47
6dm1C-4gq2M:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4gq2 NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		5 / 11 SER M 283
LEU M 252
SER M 239
LEU M 174
ASP M 113
 None
 1.26A 6dm1A-4gq2M:
5.6
6dm1D-4gq2M:
2.6		 6dm1A-4gq2M:
6.47
6dm1D-4gq2M:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 4gq2 NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		5 / 12 VAL M 731
SER M 732
PHE M 802
TRP M 834
VAL M 603
 None
 1.32A 6drxA-4gq2M:
undetectable		 6drxA-4gq2M:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_D95A816_0
(GEPHYRIN)		 4gq2 NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		5 / 11 MET M 251
ILE M 297
LEU M 314
LEU M 261
ILE M 178
 None
 1.38A 6fgcA-4gq2M:
undetectable		 6fgcA-4gq2M:
5.80