SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gq9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4X1I_B_LOCB502_1 (TUBULIN ALPHA CHAIN TUBULIN BETA CHAIN)	4gq9	CHIKUNGUNYA VIRUS NEUTRALIZING ANTIBODY 9.8B FAB FRAGMENT HEAVY CHAIN (Mus musculus)	3 / 3	SER H 208 ALA H 203 VAL H 202	None	0.60A	4x1iA-4gq9H: undetectable	4x1iA-4gq9H: 18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EYP_B_LOCB502_1 (TUBULIN ALPHA CHAIN TUBULIN BETA CHAIN)	4gq9	CHIKUNGUNYA VIRUS NEUTRALIZING ANTIBODY 9.8B FAB FRAGMENT HEAVY CHAIN (Mus musculus)	3 / 3	SER H 208 ALA H 203 VAL H 202	None	0.56A	5eypA-4gq9H: undetectable	5eypA-4gq9H: 19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIW_D_LOCD503_1 (TUBULIN ALPHA-1B CHAIN TUBULIN BETA CHAIN)	4gq9	CHIKUNGUNYA VIRUS NEUTRALIZING ANTIBODY 9.8B FAB FRAGMENT HEAVY CHAIN (Mus musculus)	3 / 3	SER H 208 ALA H 203 VAL H 202	None	0.50A	5xiwC-4gq9H: undetectable	5xiwC-4gq9H: 16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DWN_B_AQ4B602_1 (CYTOCHROME P450 1A1)	4gq9	CHIKUNGUNYA VIRUS NEUTRALIZING ANTIBODY 9.8B FAB FRAGMENT HEAVY CHAIN (Mus musculus)	4 / 7	GLY H 8 ALA H 9 VAL H 18 LEU H 20	None	0.84A	6dwnB-4gq9H: undetectable	6dwnB-4gq9H: 16.51

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["4X1I_B_LOCB502_1","TUBULIN ALPHA CHAIN;TUBULIN BETA CHAIN","4gq9","CHIKUNGUNYA VIRUS NEUTRALIZING ANTIBODY 9.8B FAB FRAGMENT HEAVY CHAIN","Mus musculus",3,"SER H 208;ALA H 203;VAL H 202","None","0.60A","4x1iA-4gq9H:undetectable","4x1iA-4gq9H:18.44"],["5EYP_B_LOCB502_1","TUBULIN ALPHA CHAIN;TUBULIN BETA CHAIN","4gq9","CHIKUNGUNYA VIRUS NEUTRALIZING ANTIBODY 9.8B FAB FRAGMENT HEAVY CHAIN","Mus musculus",3,"SER H 208;ALA H 203;VAL H 202","None","0.56A","5eypA-4gq9H:undetectable","5eypA-4gq9H:19.37"],["5XIW_D_LOCD503_1","TUBULIN ALPHA-1B CHAIN;TUBULIN BETA CHAIN","4gq9","CHIKUNGUNYA VIRUS NEUTRALIZING ANTIBODY 9.8B FAB FRAGMENT HEAVY CHAIN","Mus musculus",3,"SER H 208;ALA H 203;VAL H 202","None","0.50A","5xiwC-4gq9H:undetectable","5xiwC-4gq9H:16.06"],["6DWN_B_AQ4B602_1","CYTOCHROME P450 1A1","4gq9","CHIKUNGUNYA VIRUS NEUTRALIZING ANTIBODY 9.8B FAB FRAGMENT HEAVY CHAIN","Mus musculus",4,"GLY H   8;ALA H   9;VAL H  18;LEU H  20","None","0.84A","6dwnB-4gq9H:undetectable","6dwnB-4gq9H:16.51"]]