SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gqb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4gqb PROTEIN ARGININE
N-METHYLTRANSFERASE
5
(Homo
sapiens) 		3 / 3 GLN A 263
ILE A 235
HIS A 250
 None
 0.55A 1fm9A-4gqbA:
undetectable		 1fm9A-4gqbA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4gqb PROTEIN ARGININE
N-METHYLTRANSFERASE
5
(Homo
sapiens) 		3 / 3 GLN A 263
ILE A 235
HIS A 250
 None
 0.55A 1k74A-4gqbA:
undetectable		 1k74A-4gqbA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q13_A_TESA501_1
(PROSTAGLANDIN-E2
9-REDUCTASE)		 4gqb PROTEIN ARGININE
N-METHYLTRANSFERASE
5
(Homo
sapiens) 		4 / 6 TYR A 468
HIS A 523
GLU A 444
PRO A 314
 None
None
0XU  A 701 (-4.3A)
None
 1.33A 1q13A-4gqbA:
3.1		 1q13A-4gqbA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 4gqb PROTEIN ARGININE
N-METHYLTRANSFERASE
5
(Homo
sapiens) 		5 / 12 TYR A 334
GLY A 365
GLY A 367
GLU A 392
ASP A 419
 0XU  A 701 (-4.6A)
0XU  A 701 (-2.9A)
0XU  A 701 ( 3.7A)
0XU  A 701 (-2.9A)
0XU  A 701 (-2.9A)
 0.95A 1qzzA-4gqbA:
8.9		 1qzzA-4gqbA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FCN_B_DVAB35_0
(UBIQUITIN)		 4gqb PROTEIN ARGININE
N-METHYLTRANSFERASE
5
(Homo
sapiens) 		4 / 6 ARG A  68
LEU A  20
GLU A  25
ILE A  26
 None
 1.10A 2fcnA-4gqbA:
undetectable
2fcnB-4gqbA:
undetectable		 2fcnA-4gqbA:
8.09
2fcnB-4gqbA:
8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 4gqb PROTEIN ARGININE
N-METHYLTRANSFERASE
5
(Homo
sapiens) 		5 / 12 GLY A 367
PRO A 370
ASN A 394
ASP A 419
LEU A 436
 0XU  A 701 ( 3.7A)
0XU  A 701 (-4.2A)
None
0XU  A 701 (-2.9A)
None
 0.87A 2zzmA-4gqbA:
9.4		 2zzmA-4gqbA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_A_SAMA206_0
(UPF0217 PROTEIN
MJ1640)		 4gqb PROTEIN ARGININE
N-METHYLTRANSFERASE
5
(Homo
sapiens) 		4 / 6 LEU A 559
GLY A 466
LEU A 565
SER A 566
 None
 0.94A 3aiaA-4gqbA:
undetectable		 3aiaA-4gqbA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_1
(N,N-DIMETHYLTRANSFER
ASE)		 4gqb PROTEIN ARGININE
N-METHYLTRANSFERASE
5
(Homo
sapiens) 		3 / 3 TYR A 334
GLU A 392
ASP A 419
 0XU  A 701 (-4.6A)
0XU  A 701 (-2.9A)
0XU  A 701 (-2.9A)
 0.73A 3bxoA-4gqbA:
8.6		 3bxoA-4gqbA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_1
(N,N-DIMETHYLTRANSFER
ASE)		 4gqb PROTEIN ARGININE
N-METHYLTRANSFERASE
5
(Homo
sapiens) 		3 / 3 TYR A 334
GLU A 392
ASP A 419
 0XU  A 701 (-4.6A)
0XU  A 701 (-2.9A)
0XU  A 701 (-2.9A)
 0.82A 3bxoB-4gqbA:
8.9		 3bxoB-4gqbA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_A_GW6A1_1
(GLUCOCORTICOID
RECEPTOR)		 4gqb PROTEIN ARGININE
N-METHYLTRANSFERASE
5
(Homo
sapiens) 		5 / 12 ASN A 112
GLY A 114
LEU A  86
LEU A 138
THR A 144
 None
 1.49A 3cldA-4gqbA:
undetectable		 3cldA-4gqbA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHT_A_SAMA200_0
(S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE)		 4gqb PROTEIN ARGININE
N-METHYLTRANSFERASE
5
(Homo
sapiens) 		5 / 12 GLY A 365
GLY A 367
GLY A 369
ASP A 419
LEU A 436
 0XU  A 701 (-2.9A)
0XU  A 701 ( 3.7A)
None
0XU  A 701 (-2.9A)
None
 0.95A 3ihtA-4gqbA:
7.2		 3ihtA-4gqbA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 4gqb PROTEIN ARGININE
N-METHYLTRANSFERASE
5
(Homo
sapiens) 		4 / 6 ARG A 368
GLY A 369
GLU A 325
GLU A 328
 None
 1.08A 3k9fA-4gqbA:
undetectable
3k9fB-4gqbA:
undetectable
3k9fD-4gqbA:
undetectable		 3k9fA-4gqbA:
21.12
3k9fB-4gqbA:
21.12
3k9fD-4gqbA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)		 4gqb PROTEIN ARGININE
N-METHYLTRANSFERASE
5
(Homo
sapiens) 		5 / 12 GLY A 365
ILE A 341
ASN A 373
VAL A 372
SER A 375
 0XU  A 701 (-2.9A)
None
None
None
None
 0.88A 3nk7A-4gqbA:
2.1		 3nk7A-4gqbA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VN2_A_TLSA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4gqb PROTEIN ARGININE
N-METHYLTRANSFERASE
5
(Homo
sapiens) 		5 / 12 SER A 199
ILE A 142
LEU A 138
LEU A 126
MET A 153
 None
 1.36A 3vn2A-4gqbA:
undetectable		 3vn2A-4gqbA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 4gqb PROTEIN ARGININE
N-METHYLTRANSFERASE
5
(Homo
sapiens) 		4 / 6 ALA A 210
PRO A 156
LEU A 163
VAL A 158
 None
 0.90A 4dubA-4gqbA:
undetectable		 4dubA-4gqbA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 4gqb PROTEIN ARGININE
N-METHYLTRANSFERASE
5
(Homo
sapiens) 		5 / 12 LEU A 258
LEU A 287
LEU A 284
ILE A 208
ILE A 235
 None
 1.30A 4j26B-4gqbA:
undetectable		 4j26B-4gqbA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K17_B_OHBB701_0
(LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A)		 4gqb PROTEIN ARGININE
N-METHYLTRANSFERASE
5
(Homo
sapiens) 		4 / 5 GLU A 207
ARG A 154
PRO A 232
SER A 234
 None
 1.28A 4k17B-4gqbA:
1.1		 4k17B-4gqbA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4gqb PROTEIN ARGININE
N-METHYLTRANSFERASE
5
(Homo
sapiens) 		4 / 8 PRO A 620
VAL A 621
VAL A 542
GLY A 595
 None
 1.02A 4mk4A-4gqbA:
undetectable		 4mk4A-4gqbA:
20.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X61_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 4gqb PROTEIN ARGININE
N-METHYLTRANSFERASE
5
(Homo
sapiens) 		12 / 12 LEU A 315
GLY A 365
GLY A 367
PRO A 370
LEU A 371
LYS A 393
ASN A 394
MET A 420
ARG A 421
GLU A 435
LEU A 436
CYH A 449
 0XU  A 701 (-3.9A)
0XU  A 701 (-2.9A)
0XU  A 701 ( 3.7A)
0XU  A 701 (-4.2A)
0XU  A 701 (-4.3A)
0XU  A 701 (-3.9A)
None
0XU  A 701 (-4.4A)
0XU  A 701 ( 4.9A)
0XU  A 701 (-4.2A)
None
0XU  A 701 (-3.6A)
 0.52A 4x61A-4gqbA:
50.3		 4x61A-4gqbA:
98.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X61_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 4gqb PROTEIN ARGININE
N-METHYLTRANSFERASE
5
(Homo
sapiens) 		5 / 5 TYR A 324
LYS A 333
TYR A 334
GLU A 392
ASP A 419
 0XU  A 701 (-4.3A)
0XU  A 701 (-3.0A)
0XU  A 701 (-4.6A)
0XU  A 701 (-2.9A)
0XU  A 701 (-2.9A)
 0.21A 4x61A-4gqbA:
50.3		 4x61A-4gqbA:
98.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EML_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 4gqb PROTEIN ARGININE
N-METHYLTRANSFERASE
5
(Homo
sapiens) 		12 / 12 PRO A 314
LEU A 315
GLY A 367
PRO A 370
LEU A 371
LYS A 393
ASN A 394
MET A 420
ARG A 421
GLU A 435
LEU A 436
CYH A 449
 None
0XU  A 701 (-3.9A)
0XU  A 701 ( 3.7A)
0XU  A 701 (-4.2A)
0XU  A 701 (-4.3A)
0XU  A 701 (-3.9A)
None
0XU  A 701 (-4.4A)
0XU  A 701 ( 4.9A)
0XU  A 701 (-4.2A)
None
0XU  A 701 (-3.6A)
 0.36A 5emlA-4gqbA:
56.2		 5emlA-4gqbA:
98.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EML_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 4gqb PROTEIN ARGININE
N-METHYLTRANSFERASE
5
(Homo
sapiens) 		6 / 6 TYR A 324
LYS A 333
TYR A 334
GLY A 365
GLU A 392
ASP A 419
 0XU  A 701 (-4.3A)
0XU  A 701 (-3.0A)
0XU  A 701 (-4.6A)
0XU  A 701 (-2.9A)
0XU  A 701 (-2.9A)
0XU  A 701 (-2.9A)
 0.17A 5emlA-4gqbA:
56.2		 5emlA-4gqbA:
98.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUN_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 4gqb PROTEIN ARGININE
N-METHYLTRANSFERASE
5
(Homo
sapiens) 		5 / 9 ALA A 390
ILE A 341
LEU A 361
ASN A 373
ALA A 366
 None
 1.00A 5nunA-4gqbA:
undetectable		 5nunA-4gqbA:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4gqb PROTEIN ARGININE
N-METHYLTRANSFERASE
5
(Homo
sapiens) 		4 / 4 LEU A 565
LEU A 559
SER A 335
ALA A 340
 None
 1.02A 5uunA-4gqbA:
undetectable		 5uunA-4gqbA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 4gqb PROTEIN ARGININE
N-METHYLTRANSFERASE
5
(Homo
sapiens) 		5 / 12 ARG A 492
PRO A 311
LEU A 472
ASN A 627
PHE A 602
 None
 1.28A 5ybbB-4gqbA:
undetectable		 5ybbB-4gqbA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4gqb PROTEIN ARGININE
N-METHYLTRANSFERASE
5
(Homo
sapiens) 		3 / 3 GLN A 263
ILE A 235
HIS A 250
 None
 0.57A 5z12B-4gqbA:
undetectable		 5z12B-4gqbA:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3A_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 4gqb PROTEIN ARGININE
N-METHYLTRANSFERASE
5
(Homo
sapiens) 		5 / 12 GLY A 365
GLY A 367
ASN A 394
ALA A 397
ASP A 419
 0XU  A 701 (-2.9A)
0XU  A 701 ( 3.7A)
None
None
0XU  A 701 (-2.9A)
 0.75A 6b3aA-4gqbA:
8.6		 6b3aA-4gqbA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3B_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 4gqb PROTEIN ARGININE
N-METHYLTRANSFERASE
5
(Homo
sapiens) 		5 / 12 GLY A 365
GLY A 367
ASN A 394
ALA A 397
ASP A 419
 0XU  A 701 (-2.9A)
0XU  A 701 ( 3.7A)
None
None
0XU  A 701 (-2.9A)
 0.73A 6b3bA-4gqbA:
8.4		 6b3bA-4gqbA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_A_W9TA201_0
(GALECTIN-1)		 4gqb PROTEIN ARGININE
N-METHYLTRANSFERASE
5
(Homo
sapiens) 		4 / 8 HIS A 549
ARG A 193
HIS A 190
GLU A 224
 None
 1.06A 6b94A-4gqbA:
undetectable		 6b94A-4gqbA:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NCS_A_ACTA303_0
(N-ACETYLNEURAMINIC
ACID (SIALIC ACID)
SYNTHETASE)		 4gqb PROTEIN ARGININE
N-METHYLTRANSFERASE
5
(Homo
sapiens) 		3 / 3 ILE A 598
THR A 597
PRO A 474
 None
 0.63A 6ncsA-4gqbA:
8.7		 6ncsA-4gqbA:
18.14