SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gqo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_1
(VITAMIN D NUCLEAR
RECEPTOR)		 4gqo LMO0859 PROTEIN
(Listeria
monocytogenes) 		5 / 12 TYR A 324
LEU A 122
LEU A 116
VAL A 119
VAL A 125
 None
 1.26A 1db1A-4gqoA:
undetectable		 1db1A-4gqoA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_2_T442129_1
(TRANSTHYRETIN)		 4gqo LMO0859 PROTEIN
(Listeria
monocytogenes) 		4 / 5 LYS A 198
LEU A 201
ALA A 197
LEU A 255
 None
 1.13A 1eta2-4gqoA:
undetectable		 1eta2-4gqoA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3003_1
(SERUM ALBUMIN)		 4gqo LMO0859 PROTEIN
(Listeria
monocytogenes) 		3 / 4 LYS A 332
ALA A 335
MET A 323
 None
 0.92A 1hk3A-4gqoA:
undetectable		 1hk3A-4gqoA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE9_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 4gqo LMO0859 PROTEIN
(Listeria
monocytogenes) 		5 / 12 TYR A 324
LEU A 122
LEU A 116
VAL A 119
VAL A 125
 None
 1.24A 1ie9A-4gqoA:
undetectable		 1ie9A-4gqoA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1436_1
(CHITINASE)		 4gqo LMO0859 PROTEIN
(Listeria
monocytogenes) 		3 / 3 ASP A 349
PHE A 371
ARG A 362
 None
 0.84A 2a3aA-4gqoA:
undetectable		 2a3aA-4gqoA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_C_H4BC1002_1
(HYPOTHETICAL PROTEIN
PH0634)		 4gqo LMO0859 PROTEIN
(Listeria
monocytogenes) 		4 / 6 ASP A 304
THR A 244
GLU A 241
GLU A 248
 None
 1.48A 2dttB-4gqoA:
undetectable
2dttC-4gqoA:
undetectable		 2dttB-4gqoA:
11.75
2dttC-4gqoA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KUH_A_HLTA150_1
(CALMODULIN)		 4gqo LMO0859 PROTEIN
(Listeria
monocytogenes) 		4 / 6 LEU A 339
LEU A 122
MET A 336
MET A  95
 None
 0.84A 2kuhA-4gqoA:
0.2		 2kuhA-4gqoA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4gqo LMO0859 PROTEIN
(Listeria
monocytogenes) 		4 / 7 VAL A 119
ALA A 335
MET A 336
LEU A 339
 None
 0.92A 2wekB-4gqoA:
undetectable		 2wekB-4gqoA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M7R_A_VDXA425_1
(VITAMIN D3 RECEPTOR)		 4gqo LMO0859 PROTEIN
(Listeria
monocytogenes) 		5 / 12 TYR A 324
LEU A 122
LEU A 116
VAL A 119
VAL A 125
 None
 1.24A 3m7rA-4gqoA:
undetectable		 3m7rA-4gqoA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_C_ACHC323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 4gqo LMO0859 PROTEIN
(Listeria
monocytogenes) 		4 / 8 PHE A 279
ASN A 357
LEU A 381
PHE A 374
 None
 1.15A 3rqwC-4gqoA:
undetectable
3rqwD-4gqoA:
undetectable		 3rqwC-4gqoA:
20.14
3rqwD-4gqoA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_J_ACHJ323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 4gqo LMO0859 PROTEIN
(Listeria
monocytogenes) 		4 / 8 LEU A 381
PHE A 374
PHE A 279
ASN A 357
 None
 1.14A 3rqwF-4gqoA:
undetectable
3rqwJ-4gqoA:
undetectable		 3rqwF-4gqoA:
20.14
3rqwJ-4gqoA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_1
(PUTATIVE REGULATORY
PROTEIN)		 4gqo LMO0859 PROTEIN
(Listeria
monocytogenes) 		3 / 3 TYR A  51
MET A 336
LEU A 148
 None
 0.88A 3vw1D-4gqoA:
undetectable		 3vw1D-4gqoA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4gqo LMO0859 PROTEIN
(Listeria
monocytogenes) 		4 / 6 ASP A 273
THR A 298
ILE A 297
PHE A 264
 None
 0.80A 4acbC-4gqoA:
undetectable		 4acbC-4gqoA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 4gqo LMO0859 PROTEIN
(Listeria
monocytogenes) 		3 / 3 LYS A 332
ASN A  63
ASP A 329
 None
 0.81A 4o1eA-4gqoA:
undetectable		 4o1eA-4gqoA:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_D_QELD503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 4gqo LMO0859 PROTEIN
(Listeria
monocytogenes) 		5 / 12 TYR A  51
THR A  47
ALA A  42
THR A  67
GLU A  69
 None
 1.21A 5ewjC-4gqoA:
undetectable
5ewjD-4gqoA:
2.3		 5ewjC-4gqoA:
22.84
5ewjD-4gqoA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4gqo LMO0859 PROTEIN
(Listeria
monocytogenes) 		4 / 6 VAL A 322
TYR A 324
MET A  73
ILE A  83
 None
 1.11A 5iwuA-4gqoA:
undetectable		 5iwuA-4gqoA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_B_EY4B500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4gqo LMO0859 PROTEIN
(Listeria
monocytogenes) 		4 / 6 VAL A 302
PRO A 173
ALA A 219
THR A 314
 None
 1.02A 6cduB-4gqoA:
undetectable
6cduC-4gqoA:
undetectable		 6cduB-4gqoA:
19.91
6cduC-4gqoA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_A_6J3A201_0
(TRANSTHYRETIN)		 4gqo LMO0859 PROTEIN
(Listeria
monocytogenes) 		4 / 4 LYS A 198
LEU A 201
ALA A 197
LEU A 255
 None
 1.14A 6gnrA-4gqoA:
undetectable		 6gnrA-4gqoA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_B_6J3B201_0
(TRANSTHYRETIN)		 4gqo LMO0859 PROTEIN
(Listeria
monocytogenes) 		4 / 4 LYS A 198
LEU A 201
ALA A 197
LEU A 255
 None
 1.11A 6gnrB-4gqoA:
undetectable		 6gnrB-4gqoA:
15.33