SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gqt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_1
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 4gqt HEAT SHOCK PROTEIN
90
(Caenorhabditis
elegans) 		5 / 12 THR A 139
ALA A 129
PHE A 126
ILE A  79
LEU A 186
 None
 1.05A 2nyrA-4gqtA:
undetectable		 2nyrA-4gqtA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q8H_A_TF4A438_1
([PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1)		 4gqt HEAT SHOCK PROTEIN
90
(Caenorhabditis
elegans) 		4 / 6 LEU A 131
TYR A  26
ILE A 119
ILE A  21
 None
 0.85A 2q8hA-4gqtA:
5.3		 2q8hA-4gqtA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGQ_A_PCFA1275_0
(WNT INHIBITORY
FACTOR 1)		 4gqt HEAT SHOCK PROTEIN
90
(Caenorhabditis
elegans) 		5 / 12 LEU A  36
LEU A  91
ILE A 174
PHE A 126
PHE A  10
 None
 0.82A 2ygqA-4gqtA:
undetectable		 2ygqA-4gqtA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		 4gqt HEAT SHOCK PROTEIN
90
(Caenorhabditis
elegans) 		4 / 5 GLN A  11
ALA A  12
GLN A  16
ILE A  14
 None
 1.07A 2z0aA-4gqtA:
undetectable		 2z0aA-4gqtA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_B_DP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 4gqt HEAT SHOCK PROTEIN
90
(Caenorhabditis
elegans) 		5 / 12 PHE A 126
GLN A 149
ALA A 133
PHE A 130
SER A 153
 None
 1.27A 3apwB-4gqtA:
undetectable		 3apwB-4gqtA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB500_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4gqt HEAT SHOCK PROTEIN
90
(Caenorhabditis
elegans) 		4 / 7 LYS A 173
THR A  78
THR A  69
VAL A 209
 None
 0.46A 3em0B-4gqtA:
undetectable		 3em0B-4gqtA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 4gqt HEAT SHOCK PROTEIN
90
(Caenorhabditis
elegans) 		5 / 12 ASN A  39
ASP A  42
ASP A  81
MET A  86
THR A 172
 ZN  A 501 ( 2.5A)
None
ADP  A 500 (-3.7A)
ADP  A 500 (-3.4A)
ADP  A 500 (-3.7A)
 0.83A 3lpsA-4gqtA:
12.1		 3lpsA-4gqtA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 4gqt HEAT SHOCK PROTEIN
90
(Caenorhabditis
elegans) 		5 / 11 ASN A  39
ASP A  42
ASP A  81
MET A  86
THR A 172
 ZN  A 501 ( 2.5A)
None
ADP  A 500 (-3.7A)
ADP  A 500 (-3.4A)
ADP  A 500 (-3.7A)
 0.79A 4urnA-4gqtA:
12.0		 4urnA-4gqtA:
26.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4gqt HEAT SHOCK PROTEIN
90
(Caenorhabditis
elegans) 		5 / 12 SER A 117
VAL A 124
LEU A  20
THR A 103
ALA A 114
 None
ADP  A 500 (-4.5A)
None
None
None
 1.15A 4x1kA-4gqtA:
undetectable
4x1kB-4gqtA:
undetectable		 4x1kA-4gqtA:
18.85
4x1kB-4gqtA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4gqt HEAT SHOCK PROTEIN
90
(Caenorhabditis
elegans) 		3 / 3 THR A  78
MET A 176
HIS A 177
 None
None
ZN  A 502 (-3.1A)
 1.00A 5uunA-4gqtA:
undetectable		 5uunA-4gqtA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4gqt HEAT SHOCK PROTEIN
90
(Caenorhabditis
elegans) 		4 / 6 ASP A 165
GLN A 149
GLU A 167
THR A  69
 None
 1.08A 6djzA-4gqtA:
undetectable		 6djzA-4gqtA:
21.05