SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gr4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_B_NIOB145_1
(LEGHEMOGLOBIN A)		 4gr4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
lydicus) 		4 / 8 PHE A 364
TYR A 245
ILE A 329
PHE A 248
 None
 0.88A 1fslB-4gr4A:
undetectable		 1fslB-4gr4A:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IA0_B_TXLB502_1
(TUBULIN BETA CHAIN)		 4gr4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
lydicus) 		5 / 12 LEU A  19
HIS A 418
THR A  61
PRO A 121
GLY A 122
 None
 1.49A 1ia0B-4gr4A:
undetectable		 1ia0B-4gr4A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1868_0
(FPRA)		 4gr4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
lydicus) 		3 / 3 ALA A 111
HIS A 112
VAL A 115
 None
 0.39A 1lqtB-4gr4A:
undetectable		 1lqtB-4gr4A:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1425_0
(FPRA)		 4gr4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
lydicus) 		3 / 3 ALA A 111
HIS A 112
VAL A 115
 None
 0.38A 1lquB-4gr4A:
undetectable		 1lquB-4gr4A:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUB_B_TXLB501_1
(TUBULIN)		 4gr4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
lydicus) 		5 / 12 LEU A  19
HIS A 418
THR A  61
PRO A 121
GLY A 122
 None
 1.50A 1tubB-4gr4A:
undetectable		 1tubB-4gr4A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_F_CLMF1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4gr4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
lydicus) 		4 / 7 GLY A 332
THR A 366
ILE A 382
GLY A 355
 None
 0.76A 1usqF-4gr4A:
undetectable		 1usqF-4gr4A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_1
(VP39)		 4gr4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
lydicus) 		3 / 3 ASP A 346
ARG A 345
ASP A 316
 None
 0.93A 1vptA-4gr4A:
undetectable		 1vptA-4gr4A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2002_1
(SERUM ALBUMIN)		 4gr4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
lydicus) 		5 / 10 ALA A 341
ALA A 343
LEU A 352
ALA A 328
VAL A 370
 None
 1.20A 2bxeA-4gr4A:
undetectable		 2bxeA-4gr4A:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_B_AZZB1211_1
(DEOXYNUCLEOSIDE
KINASE)		 4gr4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
lydicus) 		5 / 12 LEU A 269
PHE A 270
VAL A  74
ALA A 214
MET A 362
 None
 1.45A 2jj8B-4gr4A:
undetectable		 2jj8B-4gr4A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_E_CLME1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4gr4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
lydicus) 		4 / 7 GLY A 332
THR A 366
ILE A 382
GLY A 355
 None
 0.75A 2jkjE-4gr4A:
undetectable		 2jkjE-4gr4A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_D_CLMD1145_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4gr4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
lydicus) 		4 / 7 GLY A 332
THR A 366
ILE A 382
GLY A 355
 None
 0.73A 2jklD-4gr4A:
undetectable		 2jklD-4gr4A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4gr4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
lydicus) 		4 / 7 GLY A 332
THR A 366
ILE A 382
GLY A 355
 None
 0.73A 2jklE-4gr4A:
undetectable		 2jklE-4gr4A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		 4gr4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
lydicus) 		4 / 6 ALA A 264
ASP A 263
ARG A 131
MET A 303
 None
 1.44A 2ouzA-4gr4A:
undetectable		 2ouzA-4gr4A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 4gr4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
lydicus) 		5 / 12 GLY A 238
GLY A 415
SER A 361
LEU A 386
LEU A 274
 None
 1.16A 3cjtG-4gr4A:
2.6		 3cjtG-4gr4A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_B_NCAB302_0
(ADP-RIBOSYL CYCLASE
1)		 4gr4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
lydicus) 		4 / 7 LEU A 416
ASP A 434
SER A 361
THR A 365
 None
 0.96A 3dzgB-4gr4A:
2.4		 3dzgB-4gr4A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_B_LOCB700_2
(TUBULIN BETA-2B
CHAIN)		 4gr4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
lydicus) 		5 / 11 LEU A 350
ALA A 328
LEU A 304
ALA A 321
VAL A 315
 None
 1.26A 3e22B-4gr4A:
undetectable		 3e22B-4gr4A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_D_LOCD700_2
(TUBULIN BETA-2B
CHAIN)		 4gr4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
lydicus) 		5 / 11 LEU A 350
ALA A 328
LEU A 304
ALA A 321
VAL A 315
 None
 1.26A 3e22D-4gr4A:
undetectable		 3e22D-4gr4A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_B_NIOB5661_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 4gr4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
lydicus) 		4 / 8 ALA A 321
PHE A 322
LEU A 255
ALA A 328
 None
 0.94A 3hrdA-4gr4A:
undetectable
3hrdB-4gr4A:
undetectable		 3hrdA-4gr4A:
24.75
3hrdB-4gr4A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4gr4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
lydicus) 		5 / 12 ALA A  88
ARG A  84
ALA A  85
VAL A 136
LEU A  92
 None
 1.24A 3uvvB-4gr4A:
undetectable		 3uvvB-4gr4A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_C_IMNC701_1
(CYCLOOXYGENASE-2)		 4gr4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
lydicus) 		5 / 12 LEU A 140
VAL A 142
GLY A 146
ALA A 145
LEU A 204
 None
 1.12A 4coxC-4gr4A:
undetectable		 4coxC-4gr4A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_A_LURA201_1
(TRANSTHYRETIN)		 4gr4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
lydicus) 		4 / 4 LYS A 144
LEU A 204
ALA A 141
VAL A 137
 None
 1.37A 4ik6A-4gr4A:
undetectable		 4ik6A-4gr4A:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J14_A_X2NA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 4gr4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
lydicus) 		5 / 10 ALA A 272
LEU A 273
PHE A  78
ARG A 278
ALA A 107
 None
 1.00A 4j14A-4gr4A:
undetectable		 4j14A-4gr4A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6V_E_RBFE201_1
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E)		 4gr4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
lydicus) 		4 / 5 HIS A  75
VAL A  74
GLU A  76
VAL A 208
 None
 1.30A 4p6vB-4gr4A:
undetectable
4p6vE-4gr4A:
undetectable		 4p6vB-4gr4A:
23.82
4p6vE-4gr4A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_2
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 4gr4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
lydicus) 		4 / 7 PRO A 232
GLU A 211
SER A 361
ASP A 449
 None
 1.24A 4uacA-4gr4A:
undetectable		 4uacA-4gr4A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_B_CHDB102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4gr4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
lydicus) 		5 / 11 LEU A 273
LEU A 140
ALA A 102
LEU A 103
TYR A 100
 None
 1.17A 4wg0B-4gr4A:
undetectable
4wg0C-4gr4A:
undetectable
4wg0D-4gr4A:
undetectable		 4wg0B-4gr4A:
2.24
4wg0C-4gr4A:
2.24
4wg0D-4gr4A:
2.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_D_CHDD102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4gr4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
lydicus) 		5 / 11 LEU A 273
LEU A 140
ALA A 102
LEU A 103
TYR A 100
 None
 1.16A 4wg0D-4gr4A:
undetectable
4wg0E-4gr4A:
undetectable
4wg0F-4gr4A:
undetectable		 4wg0D-4gr4A:
2.24
4wg0E-4gr4A:
2.24
4wg0F-4gr4A:
2.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4gr4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
lydicus) 		5 / 11 LEU A 273
LEU A 140
ALA A 102
LEU A 103
TYR A 100
 None
 1.16A 4wg0F-4gr4A:
undetectable
4wg0G-4gr4A:
undetectable
4wg0H-4gr4A:
undetectable		 4wg0F-4gr4A:
2.24
4wg0G-4gr4A:
2.24
4wg0H-4gr4A:
2.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_H_CHDH103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4gr4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
lydicus) 		5 / 11 LEU A 273
LEU A 140
ALA A 102
LEU A 103
TYR A 100
 None
 1.17A 4wg0H-4gr4A:
undetectable
4wg0I-4gr4A:
undetectable
4wg0J-4gr4A:
undetectable		 4wg0H-4gr4A:
2.24
4wg0I-4gr4A:
2.24
4wg0J-4gr4A:
2.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_I_CHDI103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4gr4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
lydicus) 		5 / 11 ALA A 102
LEU A 103
TYR A 100
LEU A 140
LEU A 273
 None
 1.16A 4wg0G-4gr4A:
undetectable
4wg0H-4gr4A:
undetectable
4wg0I-4gr4A:
undetectable		 4wg0G-4gr4A:
2.24
4wg0H-4gr4A:
2.24
4wg0I-4gr4A:
2.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_J_CHDJ103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4gr4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
lydicus) 		5 / 11 LEU A 273
LEU A 140
ALA A 102
LEU A 103
TYR A 100
 None
 1.15A 4wg0J-4gr4A:
undetectable
4wg0K-4gr4A:
undetectable
4wg0L-4gr4A:
undetectable		 4wg0J-4gr4A:
2.24
4wg0K-4gr4A:
2.24
4wg0L-4gr4A:
2.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_K_CHDK103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4gr4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
lydicus) 		5 / 11 ALA A 102
LEU A 103
TYR A 100
LEU A 140
LEU A 273
 None
 1.15A 4wg0I-4gr4A:
undetectable
4wg0J-4gr4A:
undetectable
4wg0K-4gr4A:
undetectable		 4wg0I-4gr4A:
2.24
4wg0J-4gr4A:
2.24
4wg0K-4gr4A:
2.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_M_CHDM103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4gr4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
lydicus) 		5 / 11 ALA A 102
LEU A 103
TYR A 100
LEU A 140
LEU A 273
 None
 1.15A 4wg0K-4gr4A:
undetectable
4wg0L-4gr4A:
undetectable
4wg0M-4gr4A:
undetectable		 4wg0K-4gr4A:
2.24
4wg0L-4gr4A:
2.24
4wg0M-4gr4A:
2.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_A_AZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4gr4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
lydicus) 		5 / 11 ASN A 104
HIS A  75
LEU A 204
THR A 206
ALA A 205
 None
 1.24A 4ygfA-4gr4A:
undetectable		 4ygfA-4gr4A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_C_AZMC303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4gr4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
lydicus) 		5 / 11 ASN A 104
HIS A  75
LEU A 204
THR A 206
ALA A 205
 None
 1.30A 4ygfC-4gr4A:
undetectable		 4ygfC-4gr4A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_D_AZMD303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4gr4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
lydicus) 		5 / 11 ASN A 104
HIS A  75
LEU A 204
THR A 206
ALA A 205
 None
 1.39A 4ygfD-4gr4A:
undetectable		 4ygfD-4gr4A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_B_DESB600_1
(ESTROGEN RECEPTOR)		 4gr4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
lydicus) 		5 / 11 LEU A  98
ALA A  90
LEU A 269
LEU A 273
LEU A 281
 None
 1.31A 4zn7B-4gr4A:
undetectable		 4zn7B-4gr4A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J21_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 4gr4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Streptomyces
lydicus) 		5 / 12 PRO A  32
HIS A  12
VAL A  13
PHE A   5
MET A 444
 None
 1.15A 6j21A-4gr4A:
undetectable		 6j21A-4gr4A:
20.77