SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4grc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_A_FOLA605_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4grc PUTATIVE MEMBRANE
PROTEIN
(Streptomyces
coelicolor) 		5 / 12 VAL A  92
LEU A 148
LEU A 415
SER A 413
ILE A 142
 None
 1.07A 1qzfA-4grcA:
undetectable		 1qzfA-4grcA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_B_FOLB609_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4grc PUTATIVE MEMBRANE
PROTEIN
(Streptomyces
coelicolor) 		5 / 12 VAL A  92
LEU A 148
LEU A 415
SER A 413
ILE A 142
 None
 1.06A 1qzfB-4grcA:
undetectable		 1qzfB-4grcA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_C_FOLC613_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4grc PUTATIVE MEMBRANE
PROTEIN
(Streptomyces
coelicolor) 		5 / 12 VAL A  92
LEU A 148
LEU A 415
SER A 413
ILE A 142
 None
 1.06A 1qzfC-4grcA:
undetectable		 1qzfC-4grcA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_D_FOLD617_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4grc PUTATIVE MEMBRANE
PROTEIN
(Streptomyces
coelicolor) 		5 / 12 VAL A  92
LEU A 148
LEU A 415
SER A 413
ILE A 142
 None
 1.07A 1qzfD-4grcA:
undetectable		 1qzfD-4grcA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_E_FOLE621_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4grc PUTATIVE MEMBRANE
PROTEIN
(Streptomyces
coelicolor) 		5 / 12 VAL A  92
LEU A 148
LEU A 415
SER A 413
ILE A 142
 None
 1.05A 1qzfE-4grcA:
undetectable		 1qzfE-4grcA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_A_8MOA501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4grc PUTATIVE MEMBRANE
PROTEIN
(Streptomyces
coelicolor) 		5 / 11 PHE A 363
VAL A 274
GLY A 373
LEU A 165
PHE A 168
 HEM  A 502 (-3.9A)
None
None
None
None
 0.82A 1z11A-4grcA:
undetectable		 1z11A-4grcA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4grc PUTATIVE MEMBRANE
PROTEIN
(Streptomyces
coelicolor) 		5 / 11 PHE A 363
VAL A 274
GLY A 373
LEU A 165
PHE A 168
 HEM  A 502 (-3.9A)
None
None
None
None
 0.84A 1z11B-4grcA:
undetectable		 1z11B-4grcA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4grc PUTATIVE MEMBRANE
PROTEIN
(Streptomyces
coelicolor) 		5 / 10 PHE A 363
VAL A 274
GLY A 373
LEU A 165
PHE A 168
 HEM  A 502 (-3.9A)
None
None
None
None
 0.83A 1z11C-4grcA:
undetectable		 1z11C-4grcA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4grc PUTATIVE MEMBRANE
PROTEIN
(Streptomyces
coelicolor) 		5 / 10 PHE A 363
VAL A 274
GLY A 373
LEU A 165
PHE A 168
 HEM  A 502 (-3.9A)
None
None
None
None
 0.83A 1z11D-4grcA:
undetectable		 1z11D-4grcA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_C_SNLC3001_1
(MINERALOCORTICOID
RECEPTOR)		 4grc PUTATIVE MEMBRANE
PROTEIN
(Streptomyces
coelicolor) 		5 / 12 ALA A 275
TRP A 213
LEU A 165
LEU A 173
PHE A 347
 None
 1.42A 2oaxC-4grcA:
undetectable		 2oaxC-4grcA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4grc PUTATIVE MEMBRANE
PROTEIN
(Streptomyces
coelicolor) 		5 / 12 VAL A  92
LEU A 148
LEU A 415
SER A 413
ILE A 142
 None
 1.14A 2oipA-4grcA:
undetectable		 2oipA-4grcA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_A_9PLA501_1
(CYTOCHROME P450 2A6)		 4grc PUTATIVE MEMBRANE
PROTEIN
(Streptomyces
coelicolor) 		5 / 11 PHE A 363
VAL A 274
GLY A 373
LEU A 165
PHE A 168
 HEM  A 502 (-3.9A)
None
None
None
None
 0.72A 3t3rA-4grcA:
undetectable		 3t3rA-4grcA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_F_ACTF402_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 4grc PUTATIVE MEMBRANE
PROTEIN
(Streptomyces
coelicolor) 		3 / 3 PHE A 362
ASP A 349
ARG A 177
 None
 0.88A 4eahF-4grcA:
undetectable		 4eahF-4grcA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_G_ACTG401_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 4grc PUTATIVE MEMBRANE
PROTEIN
(Streptomyces
coelicolor) 		3 / 3 PHE A 362
ASP A 349
ARG A 177
 None
 0.89A 4eahG-4grcA:
undetectable		 4eahG-4grcA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_A_MTXA603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 4grc PUTATIVE MEMBRANE
PROTEIN
(Streptomyces
coelicolor) 		5 / 12 VAL A  92
LEU A 148
LEU A 415
SER A 413
ILE A 142
 None
 1.11A 4ky8A-4grcA:
undetectable		 4ky8A-4grcA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_B_MTXB603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 4grc PUTATIVE MEMBRANE
PROTEIN
(Streptomyces
coelicolor) 		5 / 12 VAL A  92
LEU A 148
LEU A 415
SER A 413
ILE A 142
 None
 1.12A 4ky8B-4grcA:
undetectable		 4ky8B-4grcA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_D_MTXD603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 4grc PUTATIVE MEMBRANE
PROTEIN
(Streptomyces
coelicolor) 		5 / 12 VAL A  92
LEU A 148
LEU A 415
SER A 413
ILE A 142
 None
 1.11A 4ky8D-4grcA:
undetectable		 4ky8D-4grcA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_E_MTXE603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 4grc PUTATIVE MEMBRANE
PROTEIN
(Streptomyces
coelicolor) 		5 / 12 VAL A  92
LEU A 148
LEU A 415
SER A 413
ILE A 142
 None
 1.12A 4ky8E-4grcA:
undetectable		 4ky8E-4grcA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 4grc PUTATIVE MEMBRANE
PROTEIN
(Streptomyces
coelicolor) 		5 / 9 PHE A 362
ALA A 365
LEU A 364
GLY A 344
ALA A 102
 None
 1.46A 4l6va-4grcA:
undetectable
4l6vf-4grcA:
undetectable		 4l6va-4grcA:
20.48
4l6vf-4grcA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RKU_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4grc PUTATIVE MEMBRANE
PROTEIN
(Streptomyces
coelicolor) 		4 / 8 PHE A 362
ALA A 365
LEU A 364
PHE A  91
 None
 1.02A 4rkuA-4grcA:
undetectable
4rkuJ-4grcA:
undetectable		 4rkuA-4grcA:
21.57
4rkuJ-4grcA:
7.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		 4grc PUTATIVE MEMBRANE
PROTEIN
(Streptomyces
coelicolor) 		4 / 4 ALA A  63
VAL A 404
GLY A 412
THR A 414
 None
 1.14A 4ubeA-4grcA:
undetectable		 4ubeA-4grcA:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XYZ_A_ACTA103_0
(POLYUBIQUITIN-C)		 4grc PUTATIVE MEMBRANE
PROTEIN
(Streptomyces
coelicolor) 		4 / 4 LEU A 252
ILE A  68
HIS A  64
VAL A 256
 None
 1.27A 4xyzA-4grcA:
undetectable		 4xyzA-4grcA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_1_PQN1842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4grc PUTATIVE MEMBRANE
PROTEIN
(Streptomyces
coelicolor) 		5 / 10 PHE A 362
ALA A 365
LEU A 364
GLY A 344
LEU A  95
 None
 1.18A 5oy01-4grcA:
undetectable
5oy07-4grcA:
undetectable		 5oy01-4grcA:
11.22
5oy07-4grcA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4grc PUTATIVE MEMBRANE
PROTEIN
(Streptomyces
coelicolor) 		5 / 12 LEU A 162
GLY A 143
MET A 267
LEU A  94
LEU A 201
 None
 1.03A 5ycnA-4grcA:
undetectable		 5ycnA-4grcA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9K_F_ACTF802_0
(UNCHARACTERIZED
PROTEIN)		 4grc PUTATIVE MEMBRANE
PROTEIN
(Streptomyces
coelicolor) 		3 / 3 TYR A 116
ALA A 110
LEU A 131
 None
 0.75A 6d9kF-4grcA:
undetectable		 6d9kF-4grcA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DHB_A_BEZA202_0
(HEPATITIS A VIRUS
CELLULAR RECEPTOR 2)		 4grc PUTATIVE MEMBRANE
PROTEIN
(Streptomyces
coelicolor) 		4 / 6 PHE A 297
ILE A 390
ASN A 387
ASP A 384
 HEM  A 502 (-4.0A)
HEM  A 502 ( 4.2A)
None
None
 1.47A 6dhbA-4grcA:
undetectable		 6dhbA-4grcA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4grc PUTATIVE MEMBRANE
PROTEIN
(Streptomyces
coelicolor) 		5 / 12 TRP A 213
LEU A 273
SER A 214
PHE A  81
HIS A  77
 None
 1.20A 6djzB-4grcA:
undetectable		 6djzB-4grcA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4grc PUTATIVE MEMBRANE
PROTEIN
(Streptomyces
coelicolor) 		5 / 12 TRP A 213
SER A 214
PHE A  81
HIS A  77
VAL A 211
 None
 1.28A 6djzB-4grcA:
undetectable		 6djzB-4grcA:
21.82