SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4grd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_2
(POL POLYPROTEIN)		 4grd PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
CATALYTIC SUBUNIT
(Burkholderia
cenocepacia) 		5 / 12 GLY A  77
ALA A  76
ASP A  25
GLY A 128
ILE A 127
 None
 0.99A 1k6cB-4grdA:
undetectable		 1k6cB-4grdA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_1
(HIV-1 PROTEASE)		 4grd PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
CATALYTIC SUBUNIT
(Burkholderia
cenocepacia) 		5 / 12 GLY A  77
ALA A  76
ASP A  25
GLY A 128
ILE A 127
 None
 1.02A 2b7zA-4grdA:
undetectable		 2b7zA-4grdA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_2
(HIV-1 PROTEASE)		 4grd PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
CATALYTIC SUBUNIT
(Burkholderia
cenocepacia) 		5 / 12 GLY A  77
ALA A  76
ASP A  25
GLY A 128
ILE A 127
 None
 0.99A 2b7zB-4grdA:
undetectable		 2b7zB-4grdA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_A_REAA1445_1
(PUTATIVE CYTOCHROME
P450 120)		 4grd PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
CATALYTIC SUBUNIT
(Burkholderia
cenocepacia) 		5 / 12 ALA A 135
LEU A  95
ALA A  71
VAL A  41
GLY A  40
 None
 1.02A 2ve3A-4grdA:
undetectable		 2ve3A-4grdA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 4grd PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
CATALYTIC SUBUNIT
(Burkholderia
cenocepacia) 		5 / 11 ALA A 135
ALA A 133
GLY A 128
GLY A  96
ILE A  73
 None
 1.18A 2x1lA-4grdA:
undetectable		 2x1lA-4grdA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_2
(PROTEASE)		 4grd PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
CATALYTIC SUBUNIT
(Burkholderia
cenocepacia) 		5 / 10 GLY A  77
ALA A  76
ASP A  25
GLY A 128
ILE A 127
 None
 1.02A 3el9B-4grdA:
undetectable		 3el9B-4grdA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GGU_B_017B201_2
(PROTEASE)		 4grd PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
CATALYTIC SUBUNIT
(Burkholderia
cenocepacia) 		5 / 9 GLY A  77
ALA A  76
ASP A  25
GLY A 128
ILE A 127
 None
 1.05A 3gguB-4grdA:
undetectable		 3gguB-4grdA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_1
(O-METHYLTRANSFERASE)		 4grd PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
CATALYTIC SUBUNIT
(Burkholderia
cenocepacia) 		3 / 3 ASP A  55
PHE A  58
SER A  49
 None
 1.02A 3i5uB-4grdA:
3.7		 3i5uB-4grdA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_1
(FIV PROTEASE)		 4grd PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
CATALYTIC SUBUNIT
(Burkholderia
cenocepacia) 		5 / 9 GLY A  77
ALA A  76
ASP A  25
GLY A 128
ILE A 127
 None
 0.90A 3ogpA-4grdA:
undetectable		 3ogpA-4grdA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_2
(POL POLYPROTEIN)		 4grd PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
CATALYTIC SUBUNIT
(Burkholderia
cenocepacia) 		5 / 9 GLY A  77
ALA A  76
ASP A  25
GLY A 128
ILE A 127
 None
 1.05A 3u7sB-4grdA:
undetectable		 3u7sB-4grdA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_1
(PROTEASE)		 4grd PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
CATALYTIC SUBUNIT
(Burkholderia
cenocepacia) 		5 / 12 GLY A  77
ALA A  76
ASP A  25
GLY A 128
ILE A 127
 None
 0.99A 3ucbA-4grdA:
undetectable		 3ucbA-4grdA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_2
(ASPARTYL PROTEASE)		 4grd PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
CATALYTIC SUBUNIT
(Burkholderia
cenocepacia) 		5 / 9 GLY A  77
ALA A  76
ASP A  25
GLY A 128
ILE A 127
 None
 1.04A 4dqcB-4grdA:
undetectable		 4dqcB-4grdA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FWD_A_BO2A801_1
(TTC1975 PEPTIDASE)		 4grd PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
CATALYTIC SUBUNIT
(Burkholderia
cenocepacia) 		5 / 9 VAL A 107
VAL A 114
GLY A  77
SER A 101
ALA A 100
 None
 1.25A 4fwdA-4grdA:
2.1		 4fwdA-4grdA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1W_A_017A104_1
(ASPARTYL PROTEASE)		 4grd PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
CATALYTIC SUBUNIT
(Burkholderia
cenocepacia) 		5 / 9 GLY A  77
ALA A  76
ASP A  25
GLY A 128
ILE A 127
 None
 1.02A 4q1wA-4grdA:
undetectable		 4q1wA-4grdA:
18.59