SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4grh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4grh AMINODEOXYCHORISMATE
SYNTHASE
(Stenotrophomonas
maltophilia) 		5 / 10 LEU A 404
ASP A 403
LEU A 402
THR A 360
THR A 390
 None
 1.34A 1i18A-4grhA:
undetectable
1i18B-4grhA:
undetectable		 1i18A-4grhA:
11.93
1i18B-4grhA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 4grh AMINODEOXYCHORISMATE
SYNTHASE
(Stenotrophomonas
maltophilia) 		5 / 11 GLY A  72
PRO A  71
GLY A  60
ASP A  59
GLN A  61
 None
None
15P  A 502 (-3.3A)
None
None
 1.12A 1jzsA-4grhA:
undetectable		 1jzsA-4grhA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T03_P_TFOP822_1
(POL POLYPROTEIN
SYNTHETIC
OLIGONUCLEOTIDE
PRIMER)		 4grh AMINODEOXYCHORISMATE
SYNTHASE
(Stenotrophomonas
maltophilia) 		4 / 7 ASP A 429
ASP A 283
ASP A 284
HIS A 335
 MG  A 507 ( 4.7A)
None
MG  A 507 (-2.6A)
None
 1.30A 1t03A-4grhA:
undetectable		 1t03A-4grhA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_A_9CRA131_1
(TRANSTHYRETIN)		 4grh AMINODEOXYCHORISMATE
SYNTHASE
(Stenotrophomonas
maltophilia) 		4 / 6 LEU A 229
LEU A 233
SER A 255
THR A 410
 None
 1.34A 1tyrA-4grhA:
undetectable		 1tyrA-4grhA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_C_STRC3001_1
(MINERALOCORTICOID
RECEPTOR)		 4grh AMINODEOXYCHORISMATE
SYNTHASE
(Stenotrophomonas
maltophilia) 		5 / 12 LEU A 159
LEU A 162
LEU A 165
ALA A 166
LEU A 139
 None
 1.02A 1ya3C-4grhA:
undetectable		 1ya3C-4grhA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_B_CQAB401_0
(HISTAMINE
N-METHYLTRANSFERASE)		 4grh AMINODEOXYCHORISMATE
SYNTHASE
(Stenotrophomonas
maltophilia) 		4 / 7 GLY A 194
PHE A 191
ASP A 186
THR A 439
 None
 1.13A 2aouB-4grhA:
undetectable		 2aouB-4grhA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 4grh AMINODEOXYCHORISMATE
SYNTHASE
(Stenotrophomonas
maltophilia) 		3 / 3 THR A 192
ASP A 283
SER A 332
 None
 0.73A 2nxeA-4grhA:
undetectable		 2nxeA-4grhA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 4grh AMINODEOXYCHORISMATE
SYNTHASE
(Stenotrophomonas
maltophilia) 		3 / 3 THR A 192
ASP A 283
SER A 332
 None
 0.79A 2nxeB-4grhA:
undetectable		 2nxeB-4grhA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 4grh AMINODEOXYCHORISMATE
SYNTHASE
(Stenotrophomonas
maltophilia) 		3 / 3 ARG A 122
ASN A 405
THR A 410
 None
 0.71A 2q63A-4grhA:
undetectable		 2q63A-4grhA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1100_1
(SERUM ALBUMIN)		 4grh AMINODEOXYCHORISMATE
SYNTHASE
(Stenotrophomonas
maltophilia) 		4 / 4 LEU A  10
ARG A  26
LEU A  19
ALA A 164
 None
 1.06A 3b9mA-4grhA:
undetectable		 3b9mA-4grhA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_1
(CYTOCHROME P450 3A4)		 4grh AMINODEOXYCHORISMATE
SYNTHASE
(Stenotrophomonas
maltophilia) 		5 / 12 LEU A 407
THR A  34
PHE A 393
ALA A 411
ALA A 236
 None
 1.17A 3nxuB-4grhA:
undetectable		 3nxuB-4grhA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_0
(YAEB-LIKE PROTEIN
RPA0152)		 4grh AMINODEOXYCHORISMATE
SYNTHASE
(Stenotrophomonas
maltophilia) 		5 / 12 LEU A 117
PRO A 362
GLY A 364
THR A 365
CYH A 374
 None
None
None
15P  A 504 (-3.9A)
None
 0.89A 3okxA-4grhA:
undetectable		 3okxA-4grhA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_1
(YAEB-LIKE PROTEIN
RPA0152)		 4grh AMINODEOXYCHORISMATE
SYNTHASE
(Stenotrophomonas
maltophilia) 		5 / 12 LEU A 117
PRO A 362
GLY A 364
THR A 365
CYH A 374
 None
None
None
15P  A 504 (-3.9A)
None
 0.89A 3okxB-4grhA:
undetectable		 3okxB-4grhA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T8N_D_EDTD135_0
(STEROID
DELTA-ISOMERASE)		 4grh AMINODEOXYCHORISMATE
SYNTHASE
(Stenotrophomonas
maltophilia) 		5 / 11 THR A 270
PRO A 272
THR A 365
GLY A 364
ARG A 310
 None
None
15P  A 504 (-3.9A)
None
None
 1.22A 3t8nD-4grhA:
undetectable
3t8nF-4grhA:
undetectable		 3t8nD-4grhA:
15.38
3t8nF-4grhA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T8N_D_EDTD135_0
(STEROID
DELTA-ISOMERASE)		 4grh AMINODEOXYCHORISMATE
SYNTHASE
(Stenotrophomonas
maltophilia) 		5 / 11 THR A 365
GLY A 364
ARG A 310
THR A 270
PRO A 272
 15P  A 504 (-3.9A)
None
None
None
None
 1.24A 3t8nD-4grhA:
undetectable
3t8nF-4grhA:
undetectable		 3t8nD-4grhA:
15.38
3t8nF-4grhA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_A_PAUA301_0
(TYPE III
PANTOTHENATE KINASE)		 4grh AMINODEOXYCHORISMATE
SYNTHASE
(Stenotrophomonas
maltophilia) 		5 / 12 VAL A 351
LEU A  75
GLY A 354
THR A 360
LEU A 402
 None
 1.28A 4o5fA-4grhA:
undetectable
4o5fB-4grhA:
undetectable		 4o5fA-4grhA:
22.83
4o5fB-4grhA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 4grh AMINODEOXYCHORISMATE
SYNTHASE
(Stenotrophomonas
maltophilia) 		4 / 7 THR A 390
THR A 410
ALA A 411
THR A 422
 None
 0.88A 4qw0K-4grhA:
undetectable		 4qw0K-4grhA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 4grh AMINODEOXYCHORISMATE
SYNTHASE
(Stenotrophomonas
maltophilia) 		4 / 7 THR A 390
THR A 410
ALA A 411
THR A 422
 None
 0.88A 4qw0Y-4grhA:
undetectable		 4qw0Y-4grhA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4grh AMINODEOXYCHORISMATE
SYNTHASE
(Stenotrophomonas
maltophilia) 		3 / 3 VAL A 253
ALA A 242
PHE A 393
 None
 0.92A 4z4iA-4grhA:
undetectable		 4z4iA-4grhA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Z_BEZZ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4grh AMINODEOXYCHORISMATE
SYNTHASE
(Stenotrophomonas
maltophilia) 		4 / 4 ILE A 408
GLY A 391
ILE A 366
LEU A 407
 15P  A 504 ( 4.9A)
None
None
None
 0.89A 5dzkl-4grhA:
undetectable
5dzkz-4grhA:
undetectable		 5dzkl-4grhA:
18.95
5dzkz-4grhA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGC_B_TA1B601_1
(TUBULIN BETA CHAIN)		 4grh AMINODEOXYCHORISMATE
SYNTHASE
(Stenotrophomonas
maltophilia) 		5 / 12 ASP A 399
THR A 360
ARG A 259
GLY A 266
LEU A 347
 None
 1.27A 5ogcB-4grhA:
undetectable		 5ogcB-4grhA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 4grh AMINODEOXYCHORISMATE
SYNTHASE
(Stenotrophomonas
maltophilia) 		4 / 7 ARG A 444
LEU A 447
ALA A 218
GLN A 219
 None
 1.31A 6b89A-4grhA:
undetectable		 6b89A-4grhA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 4grh AMINODEOXYCHORISMATE
SYNTHASE
(Stenotrophomonas
maltophilia) 		4 / 7 ARG A 448
ARG A 444
ALA A 218
GLN A 219
 None
 1.13A 6b89A-4grhA:
undetectable		 6b89A-4grhA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA816_0
(UNCHARACTERIZED
PROTEIN)		 4grh AMINODEOXYCHORISMATE
SYNTHASE
(Stenotrophomonas
maltophilia) 		3 / 3 ARG A 214
ARG A 190
ASP A 186
 None
 0.98A 6d8pA-4grhA:
undetectable		 6d8pA-4grhA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)		 4grh AMINODEOXYCHORISMATE
SYNTHASE
(Stenotrophomonas
maltophilia) 		4 / 6 THR A 367
CYH A 369
GLY A 364
ARG A 310
 None
 0.94A 6gtqB-4grhA:
undetectable
6gtqD-4grhA:
undetectable		 6gtqB-4grhA:
16.38
6gtqD-4grhA:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_B_NMYB302_0
(AAC(3)-IIIB PROTEIN)		 4grh AMINODEOXYCHORISMATE
SYNTHASE
(Stenotrophomonas
maltophilia) 		5 / 10 ASP A 186
ASP A 437
THR A 422
GLY A 423
GLU A 435
 None
None
None
15P  A 504 (-3.8A)
None
 1.39A 6mb9B-4grhA:
undetectable		 6mb9B-4grhA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_C_NMYC302_0
(AAC(3)-IIIB PROTEIN)		 4grh AMINODEOXYCHORISMATE
SYNTHASE
(Stenotrophomonas
maltophilia) 		5 / 10 ASP A 186
ASP A 437
THR A 422
GLY A 423
GLU A 435
 None
None
None
15P  A 504 (-3.8A)
None
 1.44A 6mb9C-4grhA:
undetectable		 6mb9C-4grhA:
13.13