SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gri'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		 4gri GLUTAMATE--TRNA
LIGASE
(Borreliella
burgdorferi) 		4 / 5 TYR A 270
PRO A 272
LEU A  65
THR A 260
 None
 1.09A 1i2wA-4griA:
undetectable		 1i2wA-4griA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZEA_A_DHIA6_0
(MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
H CHAIN
MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
L CHAIN
SHORT SYNTHETIC
D-AMINO ACID PEPTIDE
D2)		 4gri GLUTAMATE--TRNA
LIGASE
(Borreliella
burgdorferi) 		3 / 3 TRP A 392
ARG A 479
PHE A 384
 None
 1.31A 1zeaH-4griA:
undetectable
1zeaL-4griA:
undetectable		 1zeaH-4griA:
16.93
1zeaL-4griA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_B_SAMB1500_0
(ASPARTOKINASE)		 4gri GLUTAMATE--TRNA
LIGASE
(Borreliella
burgdorferi) 		4 / 7 ASP A 203
ARG A   5
LEU A  39
GLU A  71
 None
 0.97A 2cdqB-4griA:
undetectable		 2cdqB-4griA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TOD_A_DMOA700_1
(PROTEIN (ORNITHINE
DECARBOXYLASE))		 4gri GLUTAMATE--TRNA
LIGASE
(Borreliella
burgdorferi) 		4 / 6 TYR A 270
ASP A 268
PHE A 265
TYR A 316
 None
 1.40A 2todA-4griA:
undetectable
2todB-4griA:
undetectable		 2todA-4griA:
20.30
2todB-4griA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 4gri GLUTAMATE--TRNA
LIGASE
(Borreliella
burgdorferi) 		5 / 12 ILE A  18
GLY A  19
GLY A  20
ALA A 215
PHE A 314
 None
 0.99A 3jayA-4griA:
undetectable		 3jayA-4griA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 4gri GLUTAMATE--TRNA
LIGASE
(Borreliella
burgdorferi) 		5 / 12 ILE A  18
GLY A  19
GLY A  20
ALA A 215
PHE A 314
 None
 0.92A 3jb2A-4griA:
undetectable		 3jb2A-4griA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_H_PZIH800_0
(GLUTAMATE RECEPTOR 2)		 4gri GLUTAMATE--TRNA
LIGASE
(Borreliella
burgdorferi) 		4 / 8 TYR A 348
SER A 376
LEU A 379
LYS A 383
 None
 0.98A 3lsfH-4griA:
undetectable		 3lsfH-4griA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAE_A_NIZA804_1
(CATALASE-PEROXIDASE)		 4gri GLUTAMATE--TRNA
LIGASE
(Borreliella
burgdorferi) 		4 / 6 TYR A 229
LEU A 228
HIS A 197
THR A 195
 None
 1.39A 4paeA-4griA:
undetectable		 4paeA-4griA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		 4gri GLUTAMATE--TRNA
LIGASE
(Borreliella
burgdorferi) 		4 / 6 LEU A 227
THR A 175
LEU A 224
SER A 221
 None
 0.89A 4pwjA-4griA:
undetectable		 4pwjA-4griA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 4gri GLUTAMATE--TRNA
LIGASE
(Borreliella
burgdorferi) 		3 / 3 ASN A 277
PHE A 302
TYR A  28
 None
 0.75A 4u15A-4griA:
undetectable		 4u15A-4griA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODC_G_ACTG704_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 4gri GLUTAMATE--TRNA
LIGASE
(Borreliella
burgdorferi) 		4 / 5 PRO A 450
ALA A 454
GLN A 484
LYS A 415
 None
 1.26A 5odcA-4griA:
undetectable
5odcG-4griA:
undetectable		 5odcA-4griA:
22.00
5odcG-4griA:
22.00