SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4grl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BC9_A_ACRA901_1
(ALPHA AMYLASE,
CATALYTIC REGION)		 4grl MHC CLASS II
HLA-DQ-ALPHA CHAIN
(Homo
sapiens) 		4 / 7 SER A 144
SER A 139
GLU A  25
ASP A  29
 None
 1.33A 3bc9A-4grlA:
5.7		 3bc9A-4grlA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B53_B_ACTB1445_0
(IG GAMMA-4 CHAIN C
REGION)		 4grl MHC CLASS II
HLA-DQ-ALPHA CHAIN
(Homo
sapiens) 		3 / 3 GLU A  25
GLY A  28
SER A   7
 None
 0.48A 4b53B-4grlA:
15.3		 4b53B-4grlA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4grl MHC CLASS II
HLA-DQ-ALPHA CHAIN
(Homo
sapiens) 		4 / 8 GLN A  21
GLU A  25
ILE A 119
VAL A 165
 None
 1.02A 4dx7B-4grlA:
undetectable		 4dx7B-4grlA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_0
(NEURAMINIDASE)		 4grl MHC CLASS II
HLA-DQ-ALPHA CHAIN
(Homo
sapiens) 		5 / 12 GLU A  25
LEU A 138
SER A 136
GLU A  30
ALA A  59
 None
 1.08A 4mx0A-4grlA:
undetectable		 4mx0A-4grlA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGZ_A_SPRA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4grl MHC CLASS II
HLA-DQ-ALPHA CHAIN
(Homo
sapiens) 		5 / 9 LEU A  12
ILE A 112
GLU A  85
PHE A 145
GLU A  25
 None
 1.50A 5igzA-4grlA:
undetectable		 5igzA-4grlA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_J_EDTJ301_0
(TCRBETA CHAIN)		 4grl MHC CLASS II
HLA-DQ-ALPHA CHAIN
(Homo
sapiens) 		4 / 5 TYR A  13
LYS A  67
GLY A  17
SER A  19
 None
 1.07A 5jhdJ-4grlA:
12.5		 5jhdJ-4grlA:
22.98