SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4grv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 4grv NEUROTENSIN RECEPTOR
TYPE 1, LYSOZYME
CHIMERA
(Escherichia
virus
T4;
Rattus
norvegicus) 		5 / 11 LEU A 118
SER A 108
LEU A 111
ASN A  82
LEU A 115
 None
 1.11A 2ceoA-4grvA:
undetectable		 2ceoA-4grvA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HW2_A_RFPA1200_1
(RIFAMPIN ADP-RIBOSYL
TRANSFERASE)		 4grv NEUROTENSIN RECEPTOR
TYPE 1, LYSOZYME
CHIMERA
(Escherichia
virus
T4;
Rattus
norvegicus) 		5 / 12 ALA A1160
GLY A1162
ASN A1002
THR A1152
GLY A1012
 None
 0.88A 2hw2A-4grvA:
undetectable		 2hw2A-4grvA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DGQ_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 4grv NEUROTENSIN RECEPTOR
TYPE 1, LYSOZYME
CHIMERA
(Escherichia
virus
T4;
Rattus
norvegicus) 		4 / 5 TYR A 347
ARG A 328
ILE A 238
THR A 233
 None
 1.25A 3dgqA-4grvA:
undetectable		 3dgqA-4grvA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4grv NEUROTENSIN RECEPTOR
TYPE 1, LYSOZYME
CHIMERA
(Rattus
norvegicus;
Escherichia
virus
T4) 		5 / 12 PHE A1004
VAL A 266
VAL A1071
ILE A1100
TYR A1088
 None
 1.25A 3elzA-4grvA:
undetectable		 3elzA-4grvA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_0
(YAEB-LIKE PROTEIN
RPA0152)		 4grv NEUROTENSIN RECEPTOR
TYPE 1, LYSOZYME
CHIMERA
(Rattus
norvegicus;
Escherichia
virus
T4) 		5 / 12 LEU A 119
CYH A 152
LEU A 117
SER A 361
LEU A 115
 None
 1.21A 3okxA-4grvA:
undetectable		 3okxA-4grvA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_1
(YAEB-LIKE PROTEIN
RPA0152)		 4grv NEUROTENSIN RECEPTOR
TYPE 1, LYSOZYME
CHIMERA
(Rattus
norvegicus;
Escherichia
virus
T4) 		5 / 12 LEU A 119
CYH A 152
LEU A 117
SER A 361
LEU A 115
 None
 1.27A 3okxB-4grvA:
undetectable		 3okxB-4grvA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_A_XRAA233_2
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4grv NEUROTENSIN RECEPTOR
TYPE 1, LYSOZYME
CHIMERA
(Escherichia
virus
T4;
Rattus
norvegicus) 		4 / 5 VAL A1149
ILE A1003
PHE A1004
PHE A1067
 None
 1.07A 3owxB-4grvA:
undetectable		 3owxB-4grvA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYS_B_VIBB501_1
(THIAMINE
PYRIDINYLASE I)		 4grv NEUROTENSIN RECEPTOR
TYPE 1, LYSOZYME
CHIMERA
(Escherichia
virus
T4;
Rattus
norvegicus) 		5 / 11 TYR A 154
ASP A 150
ILE A 238
TYR A 324
LEU A 329
 None
 1.43A 4kysB-4grvA:
undetectable		 4kysB-4grvA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_B_MXMB807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4grv NEUROTENSIN RECEPTOR
TYPE 1, LYSOZYME
CHIMERA
(Escherichia
virus
T4;
Rattus
norvegicus) 		5 / 12 LEU A 106
VAL A 313
LEU A 368
SER A 164
LEU A 163
 None
 1.02A 4o1zB-4grvA:
undetectable		 4o1zB-4grvA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4grv NEUROTENSIN RECEPTOR
TYPE 1, LYSOZYME
CHIMERA
(Rattus
norvegicus;
Escherichia
virus
T4) 		4 / 7 THR A1026
TYR A1018
GLU A1011
HIS A1031
 None
None
EPE  A 602 ( 4.8A)
None
 1.02A 5ecnA-4grvA:
undetectable		 5ecnA-4grvA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4grv NEUROTENSIN RECEPTOR
TYPE 1, LYSOZYME
CHIMERA
(Rattus
norvegicus;
Escherichia
virus
T4) 		3 / 3 ALA A 166
GLN A  99
THR A 101
 None
 0.68A 5n0oA-4grvA:
undetectable		 5n0oA-4grvA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_C_SAMC201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4grv NEUROTENSIN RECEPTOR
TYPE 1, LYSOZYME
CHIMERA
(Rattus
norvegicus;
Escherichia
virus
T4) 		5 / 12 LEU A 114
ASP A 113
ILE A 116
LEU A 118
LEU A 119
 None
 1.14A 5twjC-4grvA:
undetectable		 5twjC-4grvA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_1
(CYTOCHROME P450 1A1)		 4grv NEUROTENSIN RECEPTOR
TYPE 1, LYSOZYME
CHIMERA
(Rattus
norvegicus;
Escherichia
virus
T4) 		3 / 3 SER A 361
SER A 362
ALA A 155
 None
 0.63A 6dwnC-4grvA:
undetectable		 6dwnC-4grvA:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA414_0
(AROMATIC
PEROXYGENASE)		 4grv NEUROTENSIN RECEPTOR
TYPE 1, LYSOZYME
CHIMERA
(Rattus
norvegicus;
Escherichia
virus
T4) 		4 / 5 PHE A 376
VAL A 259
PRO A 174
VAL A 379
 None
 1.33A 6ekzA-4grvA:
undetectable		 6ekzA-4grvA:
10.02