SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4grw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_A_BEZA1529_0
(BENZOATE-COENZYME A
LIGASE)		 4grw NANOBODY 124C4
(Lama
glama) 		5 / 9 ALA E  61
TYR E  60
ALA E  58
GLY E  50
ILE E  70
 None
 1.27A 2v7bA-4grwE:
undetectable		 2v7bA-4grwE:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 4grw NANOBODY 124C4
(Lama
glama) 		5 / 9 ALA E  61
TYR E  60
ALA E  58
GLY E  50
ILE E  70
 None
 1.25A 2v7bB-4grwE:
undetectable		 2v7bB-4grwE:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1001_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4grw NANOBODY 22E11
(Lama
glama) 		4 / 6 SER H  54
ARG H  52
PRO H  58
GLY H  56
 None
 1.39A 2y7pA-4grwH:
undetectable		 2y7pA-4grwH:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_3
(NS3 PROTEASE, NS4A
PROTEIN)		 4grw NANOBODY 22E11
(Lama
glama) 		4 / 5 SER H  85
ARG H  87
PRO H  88
VAL H 121
 None
 1.11A 3sufC-4grwH:
undetectable		 3sufC-4grwH:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRQ_C_AVLC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4grw NANOBODY 22E11
(Lama
glama) 		4 / 7 PHE H  37
TYR H 110
PRO H 103
TYR H  59
 None
 0.93A 4grqA-4grwH:
undetectable
4grqC-4grwH:
undetectable		 4grqA-4grwH:
18.57
4grqC-4grwH:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4grw NANOBODY 37D5
(Lama
glama) 		4 / 7 ALA F  92
THR F  91
VAL F 122
GLU F  89
 None
 0.74A 5ecmD-4grwF:
undetectable		 5ecmD-4grwF:
12.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CJK_B_ACTB302_0
(IMMUNOGLOBULIN FAB
HEAVY CHAIN)		 4grw NANOBODY 37D5
(Lama
glama) 		3 / 3 TYR F  60
GLY F  66
THR F  69
 None
 0.16A 6cjkB-4grwF:
17.4		 6cjkB-4grwF:
51.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_A_SAMA401_0
(O-METHYLTRANSFERASE)		 4grw NANOBODY 22E11
(Lama
glama) 		5 / 12 ALA H  24
GLY H  35
GLY H  97
SER H 105
VAL H  79
 None
 1.30A 6clxA-4grwH:
undetectable		 6clxA-4grwH:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA816_0
(UNCHARACTERIZED
PROTEIN)		 4grw NANOBODY 124C4
(Lama
glama) 		3 / 3 ARG E 100
ARG E  98
ASP E 113
 None
 0.66A 6d8pA-4grwE:
undetectable		 6d8pA-4grwE:
11.55