SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4grx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_1
(ESTROGEN RECEPTOR)		 4grx AMINOTRANSFERASE
(Paracoccus
denitrificans) 		5 / 12 ALA A 383
GLU A 382
LEU A 381
ARG A 186
LEU A 441
 None
 1.01A 1errB-4grxA:
undetectable		 1errB-4grxA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_2
(HIV-1 PROTEASE)		 4grx AMINOTRANSFERASE
(Paracoccus
denitrificans) 		3 / 3 ARG A  48
THR A  34
VAL A  42
 None
 0.91A 1hxbA-4grxA:
undetectable		 1hxbA-4grxA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 4grx AMINOTRANSFERASE
(Paracoccus
denitrificans) 		4 / 4 HIS A 326
ALA A 323
PHE A 321
GLY A 325
 None
 1.42A 1mjoA-4grxA:
undetectable		 1mjoA-4grxA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_C_SAMC199_0
(METHIONINE REPRESSOR)		 4grx AMINOTRANSFERASE
(Paracoccus
denitrificans) 		5 / 10 GLU A 119
HIS A 326
PRO A 293
ALA A 323
PHE A 321
 None
 1.42A 1mjqC-4grxA:
undetectable
1mjqD-4grxA:
undetectable		 1mjqC-4grxA:
13.30
1mjqD-4grxA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_B_C2FB802_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 4grx AMINOTRANSFERASE
(Paracoccus
denitrificans) 		5 / 12 GLY A 136
ILE A 177
GLY A 219
ARG A 306
ILE A 217
 None
 1.07A 1q8jB-4grxA:
undetectable		 1q8jB-4grxA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_B_ADNB1502_1
(CLASS B ACID
PHOSPHATASE)		 4grx AMINOTRANSFERASE
(Paracoccus
denitrificans) 		4 / 7 GLU A 436
TYR A  40
LEU A  50
THR A 430
 None
 1.22A 1rmtB-4grxA:
2.6		 1rmtB-4grxA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA472_1
(CYTOCHROME P450 51)		 4grx AMINOTRANSFERASE
(Paracoccus
denitrificans) 		4 / 6 VAL A 422
LEU A 423
PHE A 356
MET A 437
 None
 1.20A 1x8vA-4grxA:
undetectable		 1x8vA-4grxA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACHA546_0
(ACETYLCHOLINESTERASE)		 4grx AMINOTRANSFERASE
(Paracoccus
denitrificans) 		4 / 8 GLU A 257
TYR A 274
PHE A 239
GLY A 270
 None
 1.04A 2ha4A-4grxA:
undetectable		 2ha4A-4grxA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_2
(PROTEASE RETROPEPSIN)		 4grx AMINOTRANSFERASE
(Paracoccus
denitrificans) 		3 / 3 ARG A  48
THR A  34
VAL A  42
 None
 0.98A 2q64A-4grxA:
undetectable		 2q64A-4grxA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_B_SAMB500_0
(HYPOTHETICAL PROTEIN)		 4grx AMINOTRANSFERASE
(Paracoccus
denitrificans) 		4 / 6 ASP A 256
VAL A 258
PHE A 221
THR A 161
 LLP  A 285 ( 3.0A)
LLP  A 285 ( 4.1A)
None
None
 1.26A 2q6oB-4grxA:
undetectable		 2q6oB-4grxA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		 4grx AMINOTRANSFERASE
(Paracoccus
denitrificans) 		3 / 3 LEU A 179
GLU A 212
ILE A 209
 None
 0.48A 3czhA-4grxA:
undetectable		 3czhA-4grxA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4grx AMINOTRANSFERASE
(Paracoccus
denitrificans) 		4 / 7 PHE A 356
PHE A 438
LYS A 440
GLY A 411
 None
 0.89A 3em0B-4grxA:
undetectable		 3em0B-4grxA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_B_KKKB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4grx AMINOTRANSFERASE
(Paracoccus
denitrificans) 		5 / 12 PHE A 427
ALA A 404
THR A 408
ILE A 413
MET A 437
 None
 1.42A 3ld6B-4grxA:
undetectable		 3ld6B-4grxA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_B_P77B204_1
(PROTEIN S100-A4)		 4grx AMINOTRANSFERASE
(Paracoccus
denitrificans) 		4 / 6 MET A 378
CYH A 424
PHE A 356
PHE A 427
 None
 1.46A 3m0wB-4grxA:
undetectable
3m0wJ-4grxA:
undetectable		 3m0wB-4grxA:
13.44
3m0wJ-4grxA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)		 4grx AMINOTRANSFERASE
(Paracoccus
denitrificans) 		5 / 12 ILE A 242
PHE A 239
TYR A 238
LEU A 246
HIS A 151
 None
 1.05A 3ozuA-4grxA:
undetectable		 3ozuA-4grxA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA1_A_08YA600_1
(CYTOCHROME P450 3A4)		 4grx AMINOTRANSFERASE
(Paracoccus
denitrificans) 		5 / 12 ARG A 366
PHE A 393
THR A 391
ALA A 444
ALA A 450
 None
 1.26A 3ua1A-4grxA:
undetectable		 3ua1A-4grxA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VN2_A_TLSA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4grx AMINOTRANSFERASE
(Paracoccus
denitrificans) 		5 / 12 SER A  90
LEU A 287
PHE A 292
MET A 294
HIS A 326
 None
 1.28A 3vn2A-4grxA:
undetectable		 3vn2A-4grxA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_B_ASWB1301_1
(DNA TOPOISOMERASE
2-BETA)		 4grx AMINOTRANSFERASE
(Paracoccus
denitrificans) 		4 / 7 ILE A 232
PRO A 233
GLY A 376
ALA A 380
 None
 0.76A 4g0uB-4grxA:
undetectable		 4g0uB-4grxA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4grx AMINOTRANSFERASE
(Paracoccus
denitrificans) 		4 / 5 LEU A 303
ARG A 247
PRO A 105
SER A 104
 None
None
None
NA  A 501 (-3.5A)
 1.22A 4kmmB-4grxA:
3.0		 4kmmB-4grxA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA4)		 4grx AMINOTRANSFERASE
(Paracoccus
denitrificans) 		4 / 7 ARG A 264
SER A  54
GLY A 266
GLU A 347
 None
 0.91A 4koeA-4grxA:
3.2
4koeB-4grxA:
3.1
4koeD-4grxA:
undetectable		 4koeA-4grxA:
23.26
4koeB-4grxA:
23.26
4koeD-4grxA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 4grx AMINOTRANSFERASE
(Paracoccus
denitrificans) 		4 / 7 GLU A 223
ARG A 373
GLY A 230
GLY A 227
 LLP  A 285 ( 3.8A)
None
None
None
 0.83A 4rdxA-4grxA:
undetectable		 4rdxA-4grxA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 4grx AMINOTRANSFERASE
(Paracoccus
denitrificans) 		4 / 6 GLY A 411
ASP A  43
ASP A  51
ASP A 409
 None
 1.05A 4uckB-4grxA:
undetectable		 4uckB-4grxA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 4grx AMINOTRANSFERASE
(Paracoccus
denitrificans) 		5 / 12 GLY A 374
LEU A 423
GLY A 230
SER A 420
PRO A 416
 None
 0.88A 5jglB-4grxA:
undetectable		 5jglB-4grxA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4grx AMINOTRANSFERASE
(Paracoccus
denitrificans) 		4 / 5 ARG A  48
ARG A  47
GLY A  46
ASP A  43
 None
 1.36A 6dwjB-4grxA:
undetectable
6dwjD-4grxA:
undetectable		 6dwjB-4grxA:
22.50
6dwjD-4grxA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA7_A_TPFA602_0
(CYTOCHROME P450 3A4)		 4grx AMINOTRANSFERASE
(Paracoccus
denitrificans) 		4 / 7 ARG A 366
ALA A 383
ILE A 363
ALA A 364
 None
 0.96A 6ma7A-4grxA:
undetectable		 6ma7A-4grxA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA604_0
(SERUM ALBUMIN)		 4grx AMINOTRANSFERASE
(Paracoccus
denitrificans) 		4 / 8 ALA A  61
GLY A 290
ALA A 336
LYS A 335
 None
LLP  A 285 ( 4.4A)
None
None
 0.76A 6mdqA-4grxA:
undetectable		 6mdqA-4grxA:
9.91