SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gs1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMI_A_BHSA1610_1
(NITRIC OXIDE
SYNTHASE)		 4gs1 DYP-TYPE PEROXIDASE
(Thermobifida
cellulosilytica) 		4 / 8 SER A 390
VAL A 392
ARG A 278
PHE A 384
 None
None
None
HEM  A 501 (-4.0A)
 0.87A 1dmiA-4gs1A:
undetectable
1dmiB-4gs1A:
undetectable		 1dmiA-4gs1A:
20.76
1dmiB-4gs1A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_1
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4gs1 DYP-TYPE PEROXIDASE
(Thermobifida
cellulosilytica) 		4 / 4 ILE A  87
LEU A 184
VAL A 140
ALA A  68
 None
 0.88A 1mz9A-4gs1A:
undetectable		 1mz9A-4gs1A:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4gs1 DYP-TYPE PEROXIDASE
(Thermobifida
cellulosilytica) 		4 / 5 ILE A  87
LEU A 184
VAL A 140
ALA A  68
 None
 0.88A 1mz9C-4gs1A:
undetectable		 1mz9C-4gs1A:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4gs1 DYP-TYPE PEROXIDASE
(Thermobifida
cellulosilytica) 		5 / 12 GLY A 187
ALA A 136
SER A 137
MET A 139
GLY A 217
 None
 1.23A 1nbiC-4gs1A:
undetectable		 1nbiC-4gs1A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4gs1 DYP-TYPE PEROXIDASE
(Thermobifida
cellulosilytica) 		5 / 12 GLY A 187
ALA A 136
SER A 137
MET A 139
GLY A 217
 None
 1.23A 1nbiD-4gs1A:
undetectable		 1nbiD-4gs1A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_A_BEZA1501_0
(RAS-RELATED PROTEIN
RAB-9A)		 4gs1 DYP-TYPE PEROXIDASE
(Thermobifida
cellulosilytica) 		4 / 5 ILE A 144
TRP A 268
LEU A 110
PRO A 421
 None
 1.27A 1s8fA-4gs1A:
undetectable
1s8fB-4gs1A:
undetectable		 1s8fA-4gs1A:
17.75
1s8fB-4gs1A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_A_8MOA501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4gs1 DYP-TYPE PEROXIDASE
(Thermobifida
cellulosilytica) 		5 / 11 PHE A 373
VAL A 276
GLY A 383
LEU A 165
PHE A 168
 HEM  A 501 (-4.0A)
None
None
GOL  A 503 (-3.8A)
None
 0.84A 1z11A-4gs1A:
undetectable		 1z11A-4gs1A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4gs1 DYP-TYPE PEROXIDASE
(Thermobifida
cellulosilytica) 		5 / 10 PHE A 373
VAL A 276
GLY A 383
LEU A 165
PHE A 168
 HEM  A 501 (-4.0A)
None
None
GOL  A 503 (-3.8A)
None
 0.85A 1z11C-4gs1A:
undetectable		 1z11C-4gs1A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4gs1 DYP-TYPE PEROXIDASE
(Thermobifida
cellulosilytica) 		5 / 10 PHE A 373
VAL A 276
GLY A 383
LEU A 165
PHE A 168
 HEM  A 501 (-4.0A)
None
None
GOL  A 503 (-3.8A)
None
 0.85A 1z11D-4gs1A:
undetectable		 1z11D-4gs1A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_1
(ANDROGEN RECEPTOR)		 4gs1 DYP-TYPE PEROXIDASE
(Thermobifida
cellulosilytica) 		5 / 12 LEU A 148
LEU A 149
GLY A 146
VAL A 412
ALA A  88
 None
 0.91A 2oz7A-4gs1A:
undetectable		 2oz7A-4gs1A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA502_0
(FERROCHELATASE)		 4gs1 DYP-TYPE PEROXIDASE
(Thermobifida
cellulosilytica) 		4 / 8 MET A 183
ARG A 353
VAL A  84
GLY A 187
 None
 1.01A 2qd3A-4gs1A:
undetectable		 2qd3A-4gs1A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA701_0
(FERROCHELATASE)		 4gs1 DYP-TYPE PEROXIDASE
(Thermobifida
cellulosilytica) 		4 / 8 MET A 183
ARG A 353
VAL A  84
GLY A 187
 None
 0.82A 2qd5A-4gs1A:
undetectable		 2qd5A-4gs1A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_E_RTLE177_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4gs1 DYP-TYPE PEROXIDASE
(Thermobifida
cellulosilytica) 		5 / 11 ALA A  70
VAL A 412
GLN A 185
GLN A 247
PHE A 252
 None
 1.31A 3bszE-4gs1A:
undetectable		 3bszE-4gs1A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 4gs1 DYP-TYPE PEROXIDASE
(Thermobifida
cellulosilytica) 		5 / 12 LEU A 201
ILE A 144
GLY A 143
VAL A 140
GLY A 422
 None
 0.99A 3bwcB-4gs1A:
undetectable		 3bwcB-4gs1A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_B_VD3B700_1
(CYTOCHROME P450 2R1)		 4gs1 DYP-TYPE PEROXIDASE
(Thermobifida
cellulosilytica) 		5 / 12 ALA A  92
ALA A 151
GLY A 145
VAL A 202
THR A 205
 None
 1.12A 3c6gB-4gs1A:
undetectable		 3c6gB-4gs1A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4gs1 DYP-TYPE PEROXIDASE
(Thermobifida
cellulosilytica) 		4 / 7 GLU A 393
SER A 390
VAL A 392
ARG A 278
 None
 1.36A 3dqtA-4gs1A:
undetectable
3dqtB-4gs1A:
undetectable		 3dqtA-4gs1A:
21.81
3dqtB-4gs1A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4gs1 DYP-TYPE PEROXIDASE
(Thermobifida
cellulosilytica) 		4 / 7 PHE A 384
SER A 390
VAL A 392
ARG A 278
 HEM  A 501 (-4.0A)
None
None
None
 0.95A 3dqtA-4gs1A:
undetectable
3dqtB-4gs1A:
undetectable		 3dqtA-4gs1A:
21.81
3dqtB-4gs1A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5T_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 4gs1 DYP-TYPE PEROXIDASE
(Thermobifida
cellulosilytica) 		4 / 7 SER A 390
VAL A 392
ARG A 278
GLU A 393
 None
 1.28A 3n5tA-4gs1A:
undetectable
3n5tB-4gs1A:
undetectable		 3n5tA-4gs1A:
20.76
3n5tB-4gs1A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5T_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 4gs1 DYP-TYPE PEROXIDASE
(Thermobifida
cellulosilytica) 		4 / 7 SER A 390
VAL A 392
ARG A 278
PHE A 384
 None
None
None
HEM  A 501 (-4.0A)
 0.89A 3n5tA-4gs1A:
undetectable
3n5tB-4gs1A:
undetectable		 3n5tA-4gs1A:
20.76
3n5tB-4gs1A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4gs1 DYP-TYPE PEROXIDASE
(Thermobifida
cellulosilytica) 		4 / 8 PHE A 384
SER A 390
VAL A 392
ARG A 278
 HEM  A 501 (-4.0A)
None
None
None
 0.92A 3nlrA-4gs1A:
undetectable
3nlrB-4gs1A:
undetectable		 3nlrA-4gs1A:
20.22
3nlrB-4gs1A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_A_9PLA501_1
(CYTOCHROME P450 2A6)		 4gs1 DYP-TYPE PEROXIDASE
(Thermobifida
cellulosilytica) 		5 / 11 PHE A 373
VAL A 276
GLY A 383
LEU A 165
PHE A 168
 HEM  A 501 (-4.0A)
None
None
GOL  A 503 (-3.8A)
None
 0.76A 3t3rA-4gs1A:
undetectable		 3t3rA-4gs1A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5J_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4gs1 DYP-TYPE PEROXIDASE
(Thermobifida
cellulosilytica) 		4 / 7 GLU A 393
SER A 390
VAL A 392
ARG A 278
 None
 1.34A 4k5jA-4gs1A:
undetectable
4k5jB-4gs1A:
undetectable		 4k5jA-4gs1A:
20.51
4k5jB-4gs1A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5J_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4gs1 DYP-TYPE PEROXIDASE
(Thermobifida
cellulosilytica) 		4 / 7 PHE A 384
SER A 390
VAL A 392
ARG A 278
 HEM  A 501 (-4.0A)
None
None
None
 0.93A 4k5jA-4gs1A:
undetectable
4k5jB-4gs1A:
undetectable		 4k5jA-4gs1A:
20.51
4k5jB-4gs1A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADL_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 4gs1 DYP-TYPE PEROXIDASE
(Thermobifida
cellulosilytica) 		4 / 7 GLU A 393
SER A 390
VAL A 392
ARG A 278
 None
 1.27A 5adlA-4gs1A:
undetectable
5adlB-4gs1A:
undetectable		 5adlA-4gs1A:
20.51
5adlB-4gs1A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADL_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 4gs1 DYP-TYPE PEROXIDASE
(Thermobifida
cellulosilytica) 		4 / 7 PHE A 384
SER A 390
VAL A 392
ARG A 278
 HEM  A 501 (-4.0A)
None
None
None
 0.90A 5adlA-4gs1A:
undetectable
5adlB-4gs1A:
undetectable		 5adlA-4gs1A:
20.51
5adlB-4gs1A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ3_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4gs1 DYP-TYPE PEROXIDASE
(Thermobifida
cellulosilytica) 		4 / 7 GLU A 393
SER A 390
VAL A 392
ARG A 278
 None
 1.32A 5fj3A-4gs1A:
undetectable
5fj3B-4gs1A:
undetectable		 5fj3A-4gs1A:
20.51
5fj3B-4gs1A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ3_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4gs1 DYP-TYPE PEROXIDASE
(Thermobifida
cellulosilytica) 		4 / 7 PHE A 384
SER A 390
VAL A 392
ARG A 278
 HEM  A 501 (-4.0A)
None
None
None
 0.90A 5fj3A-4gs1A:
undetectable
5fj3B-4gs1A:
undetectable		 5fj3A-4gs1A:
20.51
5fj3B-4gs1A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA612_1
(SERUM ALBUMIN)		 4gs1 DYP-TYPE PEROXIDASE
(Thermobifida
cellulosilytica) 		5 / 12 GLU A 126
LEU A 138
LEU A 120
LEU A 201
ALA A 196
 None
 1.05A 5v0vA-4gs1A:
undetectable		 5v0vA-4gs1A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV7_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4gs1 DYP-TYPE PEROXIDASE
(Thermobifida
cellulosilytica) 		4 / 7 GLU A 393
SER A 390
VAL A 392
ARG A 278
 None
 1.31A 5vv7A-4gs1A:
undetectable
5vv7B-4gs1A:
undetectable		 5vv7A-4gs1A:
20.51
5vv7B-4gs1A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV7_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4gs1 DYP-TYPE PEROXIDASE
(Thermobifida
cellulosilytica) 		4 / 7 PHE A 384
SER A 390
VAL A 392
ARG A 278
 HEM  A 501 (-4.0A)
None
None
None
 0.88A 5vv7A-4gs1A:
undetectable
5vv7B-4gs1A:
undetectable		 5vv7A-4gs1A:
20.51
5vv7B-4gs1A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVN_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4gs1 DYP-TYPE PEROXIDASE
(Thermobifida
cellulosilytica) 		4 / 7 GLU A 393
SER A 390
VAL A 392
ARG A 278
 None
 1.34A 5vvnA-4gs1A:
undetectable
5vvnB-4gs1A:
undetectable		 5vvnA-4gs1A:
20.51
5vvnB-4gs1A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVN_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4gs1 DYP-TYPE PEROXIDASE
(Thermobifida
cellulosilytica) 		4 / 7 PHE A 384
SER A 390
VAL A 392
ARG A 278
 HEM  A 501 (-4.0A)
None
None
None
 0.90A 5vvnA-4gs1A:
undetectable
5vvnB-4gs1A:
undetectable		 5vvnA-4gs1A:
20.51
5vvnB-4gs1A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YN6_A_SAMA401_0
(NSP16 PROTEIN)		 4gs1 DYP-TYPE PEROXIDASE
(Thermobifida
cellulosilytica) 		5 / 12 GLY A 370
GLY A 360
ASN A 356
ASP A 240
MET A 282
 None
None
None
OXY  A 502 (-2.9A)
None
 1.30A 5yn6A-4gs1A:
undetectable		 5yn6A-4gs1A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNI_A_SAMA401_0
(NSP16 PROTEIN)		 4gs1 DYP-TYPE PEROXIDASE
(Thermobifida
cellulosilytica) 		5 / 12 GLY A 370
GLY A 360
ASN A 356
ASP A 240
MET A 282
 None
None
None
OXY  A 502 (-2.9A)
None
 1.29A 5yniA-4gs1A:
undetectable		 5yniA-4gs1A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNM_A_SAMA401_0
(NSP16 PROTEIN)		 4gs1 DYP-TYPE PEROXIDASE
(Thermobifida
cellulosilytica) 		5 / 12 GLY A 370
GLY A 360
ASN A 356
ASP A 240
MET A 282
 None
None
None
OXY  A 502 (-2.9A)
None
 1.28A 5ynmA-4gs1A:
undetectable		 5ynmA-4gs1A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB501_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4gs1 DYP-TYPE PEROXIDASE
(Thermobifida
cellulosilytica) 		4 / 7 SER A 390
VAL A 392
ARG A 278
GLU A 393
 None
 1.35A 6av6A-4gs1A:
undetectable
6av6B-4gs1A:
undetectable		 6av6A-4gs1A:
12.24
6av6B-4gs1A:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB501_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4gs1 DYP-TYPE PEROXIDASE
(Thermobifida
cellulosilytica) 		4 / 7 SER A 390
VAL A 392
ARG A 278
PHE A 384
 None
None
None
HEM  A 501 (-4.0A)
 0.95A 6av6A-4gs1A:
undetectable
6av6B-4gs1A:
undetectable		 6av6A-4gs1A:
12.24
6av6B-4gs1A:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4gs1 DYP-TYPE PEROXIDASE
(Thermobifida
cellulosilytica) 		4 / 7 GLU A 393
SER A 390
VAL A 392
ARG A 278
 None
 1.31A 6av6C-4gs1A:
undetectable
6av6D-4gs1A:
undetectable		 6av6C-4gs1A:
12.24
6av6D-4gs1A:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4gs1 DYP-TYPE PEROXIDASE
(Thermobifida
cellulosilytica) 		4 / 7 PHE A 384
SER A 390
VAL A 392
ARG A 278
 HEM  A 501 (-4.0A)
None
None
None
 0.99A 6av6C-4gs1A:
undetectable
6av6D-4gs1A:
undetectable		 6av6C-4gs1A:
12.24
6av6D-4gs1A:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4gs1 DYP-TYPE PEROXIDASE
(Thermobifida
cellulosilytica) 		4 / 7 SER A 390
VAL A 392
ARG A 278
GLU A 393
 None
 1.39A 6av7A-4gs1A:
undetectable
6av7B-4gs1A:
undetectable		 6av7A-4gs1A:
12.24
6av7B-4gs1A:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4gs1 DYP-TYPE PEROXIDASE
(Thermobifida
cellulosilytica) 		4 / 7 SER A 390
VAL A 392
ARG A 278
PHE A 384
 None
None
None
HEM  A 501 (-4.0A)
 0.96A 6av7A-4gs1A:
undetectable
6av7B-4gs1A:
undetectable		 6av7A-4gs1A:
12.24
6av7B-4gs1A:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_B_SAMB401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 4gs1 DYP-TYPE PEROXIDASE
(Thermobifida
cellulosilytica) 		5 / 12 LEU A 372
GLY A 354
SER A 273
VAL A 256
VAL A 351
 None
 1.39A 6bxlB-4gs1A:
undetectable		 6bxlB-4gs1A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4gs1 DYP-TYPE PEROXIDASE
(Thermobifida
cellulosilytica) 		5 / 12 TRP A 213
SER A 214
PHE A  89
HIS A  85
VAL A 211
 None
 1.34A 6djzB-4gs1A:
undetectable		 6djzB-4gs1A:
21.27