SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gs4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		 4gs4 ALPHA-TUBULIN
N-ACETYLTRANSFERASE
(Homo
sapiens) 		4 / 8 TYR A 101
GLU A 117
VAL A  76
HIS A  75
 None
 1.22A 3b9lA-4gs4A:
undetectable		 3b9lA-4gs4A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IEO_A_AMJA300_0
(CARBONIC ANHYDRASE 2)		 4gs4 ALPHA-TUBULIN
N-ACETYLTRANSFERASE
(Homo
sapiens) 		4 / 4 ILE A 185
GLN A 179
VAL A 106
PHE A 190
 None
 1.44A 3ieoA-4gs4A:
undetectable		 3ieoA-4gs4A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC800_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 4gs4 ALPHA-TUBULIN
N-ACETYLTRANSFERASE
(Homo
sapiens) 		3 / 3 ASP A 108
ARG A 110
ALA A 112
 None
 0.69A 3mbgC-4gs4A:
undetectable		 3mbgC-4gs4A:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_B_HFGB1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 4gs4 ALPHA-TUBULIN
N-ACETYLTRANSFERASE
(Homo
sapiens) 		5 / 12 LEU A 164
VAL A 184
PRO A 159
THR A  65
SER A  54
 None
 1.30A 4hvcB-4gs4A:
undetectable		 4hvcB-4gs4A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA502_1
(CYTOCHROME P450 2C9)		 4gs4 ALPHA-TUBULIN
N-ACETYLTRANSFERASE
(Homo
sapiens) 		5 / 12 PHE A 186
ASN A 181
LEU A 104
VAL A 106
LEU A 164
 None
 1.15A 5x24A-4gs4A:
undetectable		 5x24A-4gs4A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_A_HFGA1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4gs4 ALPHA-TUBULIN
N-ACETYLTRANSFERASE
(Homo
sapiens) 		5 / 12 LEU A 164
VAL A 184
PRO A 159
THR A  65
SER A  54
 None
 1.29A 5xiqA-4gs4A:
undetectable		 5xiqA-4gs4A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4gs4 ALPHA-TUBULIN
N-ACETYLTRANSFERASE
(Homo
sapiens) 		5 / 12 LEU A 164
VAL A 184
PRO A 159
THR A  65
SER A  54
 None
 1.34A 5xiqB-4gs4A:
undetectable		 5xiqB-4gs4A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_HFGA603_0
(UNCHARACTERIZED
PROTEIN)		 4gs4 ALPHA-TUBULIN
N-ACETYLTRANSFERASE
(Homo
sapiens) 		5 / 12 LEU A 164
VAL A 184
PRO A 159
THR A  65
SER A  54
 None
 1.29A 6mn8A-4gs4A:
undetectable		 6mn8A-4gs4A:
19.11