SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gs5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_B_MTXB171_1
(DIHYDROFOLATE
REDUCTASE)		 4gs5 ACYL-COA SYNTHETASE
(AMP-FORMING)/AMP-AC
ID LIGASE II-LIKE
PROTEIN
(Dyadobacter
fermentans) 		5 / 12 VAL A 296
ASP A 263
ILE A 275
LEU A 309
ILE A 297
 None
 1.07A 1d1gB-4gs5A:
undetectable		 1d1gB-4gs5A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_F_REAF177_1
(RETINOL BINDING
PROTEIN)		 4gs5 ACYL-COA SYNTHETASE
(AMP-FORMING)/AMP-AC
ID LIGASE II-LIKE
PROTEIN
(Dyadobacter
fermentans) 		5 / 11 LEU A 147
ALA A 139
VAL A 150
LEU A 152
GLN A 130
 None
None
None
None
EDO  A 413 ( 4.5A)
 1.07A 1rlbF-4gs5A:
undetectable		 1rlbF-4gs5A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		 4gs5 ACYL-COA SYNTHETASE
(AMP-FORMING)/AMP-AC
ID LIGASE II-LIKE
PROTEIN
(Dyadobacter
fermentans) 		4 / 7 THR A 140
PRO A 112
VAL A 124
LEU A 161
 None
 1.01A 2hdnE-4gs5A:
undetectable
2hdnF-4gs5A:
undetectable
2hdnH-4gs5A:
undetectable		 2hdnE-4gs5A:
8.85
2hdnF-4gs5A:
20.64
2hdnH-4gs5A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		 4gs5 ACYL-COA SYNTHETASE
(AMP-FORMING)/AMP-AC
ID LIGASE II-LIKE
PROTEIN
(Dyadobacter
fermentans) 		4 / 7 VAL A 124
LEU A 161
THR A 140
PRO A 112
 None
 1.03A 2hdnF-4gs5A:
undetectable
2hdnG-4gs5A:
undetectable
2hdnH-4gs5A:
undetectable		 2hdnF-4gs5A:
20.64
2hdnG-4gs5A:
8.85
2hdnH-4gs5A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA504_0
(CHORISMATE SYNTHASE)		 4gs5 ACYL-COA SYNTHETASE
(AMP-FORMING)/AMP-AC
ID LIGASE II-LIKE
PROTEIN
(Dyadobacter
fermentans) 		4 / 5 SER A 183
ARG A  95
LEU A 202
SER A  62
 EDO  A 414 (-3.3A)
EDO  A 414 ( 4.3A)
None
None
 1.20A 2qhfA-4gs5A:
undetectable		 2qhfA-4gs5A:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		 4gs5 ACYL-COA SYNTHETASE
(AMP-FORMING)/AMP-AC
ID LIGASE II-LIKE
PROTEIN
(Dyadobacter
fermentans) 		4 / 8 SER A  43
TYR A  86
PRO A 108
THR A 179
 None
 0.99A 2v0zO-4gs5A:
undetectable		 2v0zO-4gs5A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_B_ADNB1302_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 4gs5 ACYL-COA SYNTHETASE
(AMP-FORMING)/AMP-AC
ID LIGASE II-LIKE
PROTEIN
(Dyadobacter
fermentans) 		4 / 6 ALA A 189
ASN A 191
PRO A 193
ALA A 195
 None
 1.16A 2zgwB-4gs5A:
undetectable		 2zgwB-4gs5A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4gs5 ACYL-COA SYNTHETASE
(AMP-FORMING)/AMP-AC
ID LIGASE II-LIKE
PROTEIN
(Dyadobacter
fermentans) 		5 / 12 LEU A 161
LEU A 152
VAL A 172
ILE A 134
LEU A 147
 None
 1.06A 3datA-4gs5A:
undetectable		 3datA-4gs5A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_E_TOPE200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4gs5 ACYL-COA SYNTHETASE
(AMP-FORMING)/AMP-AC
ID LIGASE II-LIKE
PROTEIN
(Dyadobacter
fermentans) 		5 / 10 LEU A 161
LEU A 152
VAL A 172
ILE A 134
LEU A 147
 None
 1.15A 3fl9E-4gs5A:
undetectable		 3fl9E-4gs5A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 4gs5 ACYL-COA SYNTHETASE
(AMP-FORMING)/AMP-AC
ID LIGASE II-LIKE
PROTEIN
(Dyadobacter
fermentans) 		5 / 12 LEU A 152
MET A   1
LEU A  79
VAL A 124
LEU A 147
 None
 1.12A 3gwxB-4gs5A:
undetectable		 3gwxB-4gs5A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 4gs5 ACYL-COA SYNTHETASE
(AMP-FORMING)/AMP-AC
ID LIGASE II-LIKE
PROTEIN
(Dyadobacter
fermentans) 		5 / 10 LEU A 161
LEU A 152
VAL A 172
ILE A 134
LEU A 147
 None
 1.12A 3jw5B-4gs5A:
undetectable		 3jw5B-4gs5A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 4gs5 ACYL-COA SYNTHETASE
(AMP-FORMING)/AMP-AC
ID LIGASE II-LIKE
PROTEIN
(Dyadobacter
fermentans) 		3 / 3 THR A   8
ASP A 100
GLU A  98
 IOD  A 412 ( 4.6A)
None
None
 0.69A 3qowA-4gs5A:
3.1		 3qowA-4gs5A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_B_TYLB2198_1
(CREB-BINDING PROTEIN)		 4gs5 ACYL-COA SYNTHETASE
(AMP-FORMING)/AMP-AC
ID LIGASE II-LIKE
PROTEIN
(Dyadobacter
fermentans) 		4 / 5 VAL A  54
LEU A  40
ILE A  87
VAL A  94
 None
 0.92A 4a9kB-4gs5A:
undetectable		 4a9kB-4gs5A:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4gs5 ACYL-COA SYNTHETASE
(AMP-FORMING)/AMP-AC
ID LIGASE II-LIKE
PROTEIN
(Dyadobacter
fermentans) 		5 / 11 ILE A 205
ALA A 186
ALA A  69
HIS A 216
LEU A 215
 None
None
EDO  A 418 ( 3.7A)
None
None
 1.09A 4nqaA-4gs5A:
undetectable		 4nqaA-4gs5A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA206_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 4gs5 ACYL-COA SYNTHETASE
(AMP-FORMING)/AMP-AC
ID LIGASE II-LIKE
PROTEIN
(Dyadobacter
fermentans) 		4 / 4 ALA A  57
ALA A  60
ALA A  61
ALA A  64
 None
None
None
EDO  A 423 (-4.1A)
 0.11A 4oadA-4gs5A:
undetectable		 4oadA-4gs5A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA208_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 4gs5 ACYL-COA SYNTHETASE
(AMP-FORMING)/AMP-AC
ID LIGASE II-LIKE
PROTEIN
(Dyadobacter
fermentans) 		4 / 4 ALA A  57
ALA A  60
ALA A  61
ALA A  64
 None
None
None
EDO  A 423 (-4.1A)
 0.13A 4oaeA-4gs5A:
undetectable		 4oaeA-4gs5A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 4gs5 ACYL-COA SYNTHETASE
(AMP-FORMING)/AMP-AC
ID LIGASE II-LIKE
PROTEIN
(Dyadobacter
fermentans) 		3 / 3 THR A   8
ASP A 100
GLU A  98
 IOD  A 412 ( 4.6A)
None
None
 0.82A 5fa8A-4gs5A:
undetectable		 5fa8A-4gs5A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4gs5 ACYL-COA SYNTHETASE
(AMP-FORMING)/AMP-AC
ID LIGASE II-LIKE
PROTEIN
(Dyadobacter
fermentans) 		4 / 9 ILE A 297
ILE A 266
ILE A 262
LEU A 259
 None
 0.77A 5vkqB-4gs5A:
undetectable
5vkqC-4gs5A:
undetectable		 5vkqB-4gs5A:
12.77
5vkqC-4gs5A:
12.77