SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gsl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4002_1
(SERUM ALBUMIN)		 4gsl AUTOPHAGY-RELATED
PROTEIN 3
(Saccharomyces
cerevisiae) 		4 / 4 ARG C 167
ALA C  76
ALA C  80
GLU C 203
 None
 1.12A 1e7bA-4gslC:
undetectable		 1e7bA-4gslC:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDT_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 4gsl AUTOPHAGY-RELATED
PROTEIN 3
(Saccharomyces
cerevisiae) 		5 / 11 SER C 225
VAL C 226
GLU C 217
SER C 230
MET C 201
 None
 1.49A 1fdtA-4gslC:
undetectable		 1fdtA-4gslC:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_B_ADNB1502_1
(CLASS B ACID
PHOSPHATASE)		 4gsl AUTOPHAGY-RELATED
PROTEIN 3
(Saccharomyces
cerevisiae) 		4 / 7 PHE C  44
LEU C 291
THR C  46
LYS C  48
 None
 0.99A 1rmtB-4gslC:
undetectable		 1rmtB-4gslC:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_B_CHDB500_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4gsl AUTOPHAGY-RELATED
PROTEIN 3
(Saccharomyces
cerevisiae) 		4 / 4 LEU C 291
VAL C 289
ILE C 288
TRP C  47
 None
 1.11A 1s9qB-4gslC:
undetectable		 1s9qB-4gslC:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q8H_A_TF4A438_1
([PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1)		 4gsl AUTOPHAGY-RELATED
PROTEIN 3
(Saccharomyces
cerevisiae) 		4 / 6 LEU C 291
TYR C 305
ILE C 173
ILE C 294
 None
 0.91A 2q8hA-4gslC:
undetectable		 2q8hA-4gslC:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NR3_A_95EA401_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3B)		 4gsl AUTOPHAGY-RELATED
PROTEIN 3
(Saccharomyces
cerevisiae) 		4 / 7 ILE C  70
PHE C  68
ASP C  55
SER C  57
 None
 1.47A 5nr3A-4gslC:
undetectable		 5nr3A-4gslC:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4gsl AUTOPHAGY-RELATED
PROTEIN 3
(Saccharomyces
cerevisiae) 		3 / 3 HIS C 232
SER C 230
LYS C 183
 None
 1.32A 5os7A-4gslC:
1.5		 5os7A-4gslC:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2S_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 4gsl AUTOPHAGY-RELATED
PROTEIN 3
(Saccharomyces
cerevisiae) 		4 / 8 PRO C 182
THR C  29
TYR C 286
PRO C  63
 None
 1.31A 5x2sI-4gslC:
undetectable
5x2sJ-4gslC:
undetectable
5x2sK-4gslC:
undetectable		 5x2sI-4gslC:
16.40
5x2sJ-4gslC:
17.63
5x2sK-4gslC:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_A_ACTA404_0
(L-LYSINE
3-HYDROXYLASE)		 4gsl AUTOPHAGY-RELATED
PROTEIN 3
(Saccharomyces
cerevisiae) 		4 / 6 ILE C 186
TYR C 169
VAL C 229
ARG C 210
 None
 1.24A 6f6jA-4gslC:
undetectable		 6f6jA-4gslC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_B_ACTB402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4gsl AUTOPHAGY-RELATED
PROTEIN 3
(Saccharomyces
cerevisiae) 		3 / 3 HIS C 232
SER C 230
LYS C 183
 None
 1.32A 6gmdB-4gslC:
1.5		 6gmdB-4gslC:
24.20