SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gsn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA501_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 4gsn GLUTATHIONE
S-TRANSFERASE E2
(Anopheles
gambiae) 		5 / 12 THR A 144
ASP A 159
ILE A 157
TYR A  86
GLN A  93
 None
 1.17A 1oltA-4gsnA:
undetectable		 1oltA-4gsnA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OSV_B_CHCB201_1
(BILE ACID RECEPTOR)		 4gsn GLUTATHIONE
S-TRANSFERASE E2
(Anopheles
gambiae) 		5 / 12 LEU A 175
MET A 170
PHE A 102
ILE A 163
ILE A 183
 None
 1.16A 1osvB-4gsnA:
undetectable		 1osvB-4gsnA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)		 4gsn GLUTATHIONE
S-TRANSFERASE E2
(Anopheles
gambiae) 		4 / 5 ILE A 163
SER A 164
PHE A 108
PRO A  14
 None
None
GSH  A 301 (-4.6A)
GSH  A 301 (-4.3A)
 1.32A 3bjwC-4gsnA:
undetectable		 3bjwC-4gsnA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_2
(DIHYDROFOLATE
REDUCTASE)		 4gsn GLUTATHIONE
S-TRANSFERASE E2
(Anopheles
gambiae) 		4 / 4 ILE A 183
ARG A  16
ILE A 187
THR A 144
 None
 0.88A 3ia4C-4gsnA:
undetectable		 3ia4C-4gsnA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M7R_A_VDXA425_1
(VITAMIN D3 RECEPTOR)		 4gsn GLUTATHIONE
S-TRANSFERASE E2
(Anopheles
gambiae) 		5 / 12 VAL A 199
SER A 164
SER A 168
GLN A  31
LEU A   6
 None
 1.33A 3m7rA-4gsnA:
undetectable		 3m7rA-4gsnA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_D_T44D328_1
(5-HYDROXYISOURATE
HYDROLASE)		 4gsn GLUTATHIONE
S-TRANSFERASE E2
(Anopheles
gambiae) 		5 / 9 LEU A   9
PRO A  13
LEU A  11
HIS A  41
LEU A 119
 None
GSH  A 301 ( 4.9A)
None
GSH  A 301 (-4.2A)
None
 1.45A 3q1eB-4gsnA:
undetectable
3q1eD-4gsnA:
undetectable		 3q1eB-4gsnA:
25.00
3q1eD-4gsnA:
25.00