SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gso'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 4gso THROMBIN-LIKE ENZYME
BJUSSUSP-1
(Bothrops
jararacussu) 		5 / 8 ASP A 172
SER A 178
VAL A 192
GLY A 195
GLY A 206
 None
 0.66A 1aq7A-4gsoA:
undetectable		 1aq7A-4gsoA:
44.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		 4gso THROMBIN-LIKE ENZYME
BJUSSUSP-1
(Bothrops
jararacussu) 		5 / 9 ASP A 172
SER A 178
VAL A 192
GLY A 195
GLY A 206
 None
 0.44A 1bcuH-4gsoA:
undetectable		 1bcuH-4gsoA:
33.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 4gso THROMBIN-LIKE ENZYME
BJUSSUSP-1
(Bothrops
jararacussu) 		5 / 12 ASP A 172
SER A 178
VAL A 192
GLY A 195
GLY A 206
 None
 0.62A 1etrH-4gsoA:
undetectable		 1etrH-4gsoA:
34.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4gso THROMBIN-LIKE ENZYME
BJUSSUSP-1
(Bothrops
jararacussu) 		5 / 8 ASP A 172
SER A 178
VAL A 192
GLY A 195
GLY A 206
 None
 0.59A 1f5lA-4gsoA:
undetectable		 1f5lA-4gsoA:
31.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TNL_A_TPAA900_1
(TRYPSIN)		 4gso THROMBIN-LIKE ENZYME
BJUSSUSP-1
(Bothrops
jararacussu) 		5 / 6 ASP A 172
SER A 178
VAL A 192
GLY A 195
GLY A 206
 None
 0.52A 1tnlA-4gsoA:
undetectable		 1tnlA-4gsoA:
43.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 4gso THROMBIN-LIKE ENZYME
BJUSSUSP-1
(Bothrops
jararacussu) 		5 / 6 ASP A 172
SER A 178
VAL A 192
GLY A 195
GLY A 206
 None
 0.46A 2otvA-4gsoA:
undetectable		 2otvA-4gsoA:
44.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 4gso THROMBIN-LIKE ENZYME
BJUSSUSP-1
(Bothrops
jararacussu) 		6 / 12 ASP A 172
SER A 178
VAL A 192
GLY A 195
GLY A 206
TYR A 208
 None
 0.45A 2p16A-4gsoA:
undetectable		 2p16A-4gsoA:
29.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_B_ACTB653_0
(ACETYL-COENZYME A
SYNTHETASE)		 4gso THROMBIN-LIKE ENZYME
BJUSSUSP-1
(Bothrops
jararacussu) 		4 / 4 VAL A   1
THR A 173
VAL A 192
GLY A 180
 None
 1.18A 2p2fB-4gsoA:
undetectable		 2p2fB-4gsoA:
16.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 4gso THROMBIN-LIKE ENZYME
BJUSSUSP-1
(Bothrops
jararacussu) 		5 / 8 ASP A 172
SER A 178
VAL A 192
GLY A 195
GLY A 206
 None
 0.65A 2vinA-4gsoA:
undetectable		 2vinA-4gsoA:
31.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 4gso THROMBIN-LIKE ENZYME
BJUSSUSP-1
(Bothrops
jararacussu) 		6 / 12 ASP A 172
SER A 178
VAL A 192
GLY A 195
GLY A 206
TYR A 208
 None
 0.34A 2w26A-4gsoA:
undetectable		 2w26A-4gsoA:
29.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_A_URFA254_1
(URIDINE
PHOSPHORYLASE)		 4gso THROMBIN-LIKE ENZYME
BJUSSUSP-1
(Bothrops
jararacussu) 		4 / 6 GLY A 190
MET A 120
ILE A 191
VAL A 211
 None
 1.14A 3kvvA-4gsoA:
undetectable		 3kvvA-4gsoA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_B_URFB254_1
(URIDINE
PHOSPHORYLASE)		 4gso THROMBIN-LIKE ENZYME
BJUSSUSP-1
(Bothrops
jararacussu) 		4 / 6 GLY A 190
MET A 120
ILE A 191
VAL A 211
 None
 1.13A 3kvvB-4gsoA:
undetectable		 3kvvB-4gsoA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_C_URFC254_1
(URIDINE
PHOSPHORYLASE)		 4gso THROMBIN-LIKE ENZYME
BJUSSUSP-1
(Bothrops
jararacussu) 		4 / 6 GLY A 190
MET A 120
ILE A 191
VAL A 211
 None
 1.16A 3kvvC-4gsoA:
undetectable		 3kvvC-4gsoA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_D_URFD254_1
(URIDINE
PHOSPHORYLASE)		 4gso THROMBIN-LIKE ENZYME
BJUSSUSP-1
(Bothrops
jararacussu) 		4 / 6 GLY A 190
MET A 120
ILE A 191
VAL A 211
 None
 1.06A 3kvvD-4gsoA:
undetectable		 3kvvD-4gsoA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_E_URFE254_1
(URIDINE
PHOSPHORYLASE)		 4gso THROMBIN-LIKE ENZYME
BJUSSUSP-1
(Bothrops
jararacussu) 		4 / 6 GLY A 190
MET A 120
ILE A 191
VAL A 211
 None
 1.11A 3kvvE-4gsoA:
undetectable		 3kvvE-4gsoA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_F_URFF254_1
(URIDINE
PHOSPHORYLASE)		 4gso THROMBIN-LIKE ENZYME
BJUSSUSP-1
(Bothrops
jararacussu) 		4 / 6 GLY A 190
MET A 120
ILE A 191
VAL A 211
 None
 1.12A 3kvvF-4gsoA:
undetectable		 3kvvF-4gsoA:
20.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 4gso THROMBIN-LIKE ENZYME
BJUSSUSP-1
(Bothrops
jararacussu) 		4 / 6 SER A 178
VAL A 192
GLY A 195
GLY A 206
 None
 0.00A 3rxfA-4gsoA:
undetectable		 3rxfA-4gsoA:
44.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		 4gso THROMBIN-LIKE ENZYME
BJUSSUSP-1
(Bothrops
jararacussu) 		4 / 5 ASP A 172
SER A 178
VAL A 192
GLY A 206
 None
 0.30A 3rxhA-4gsoA:
undetectable		 3rxhA-4gsoA:
44.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_1
(PROTEASE)		 4gso THROMBIN-LIKE ENZYME
BJUSSUSP-1
(Bothrops
jararacussu) 		5 / 9 ALA A 164
ILE A 119
VAL A 192
GLY A 195
ILE A 141
 None
 0.78A 3s43A-4gsoA:
undetectable		 3s43A-4gsoA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_B_RITB401_2
(SECRETED ASPARTIC
PROTEASE)		 4gso THROMBIN-LIKE ENZYME
BJUSSUSP-1
(Bothrops
jararacussu) 		4 / 7 SER A 178
THR A 209
THR A 161
TYR A 214
 None
 0.95A 3tneB-4gsoA:
undetectable		 3tneB-4gsoA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_0
(PUTATIVE REGULATORY
PROTEIN)		 4gso THROMBIN-LIKE ENZYME
BJUSSUSP-1
(Bothrops
jararacussu) 		5 / 12 THR A  37
ILE A 191
TYR A 208
ILE A 141
ALA A 139
 None
 1.26A 3vw1D-4gsoA:
undetectable		 3vw1D-4gsoA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_F_URFF1301_1
(URIDINE
PHOSPHORYLASE)		 4gso THROMBIN-LIKE ENZYME
BJUSSUSP-1
(Bothrops
jararacussu) 		4 / 6 GLY A 190
MET A 120
ILE A 191
VAL A 211
 None
 1.12A 4e1vF-4gsoA:
undetectable		 4e1vF-4gsoA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		 4gso THROMBIN-LIKE ENZYME
BJUSSUSP-1
(Bothrops
jararacussu) 		3 / 3 PRO A 133
TYR A 137
GLY A 121
 None
 0.70A 4g2zA-4gsoA:
undetectable		 4g2zA-4gsoA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4gso THROMBIN-LIKE ENZYME
BJUSSUSP-1
(Bothrops
jararacussu) 		5 / 10 SER A  20
LEU A  27
ILE A  89
PRO A  67
SER A  43
 None
 1.40A 6dlzB-4gsoA:
undetectable
6dlzC-4gsoA:
undetectable		 6dlzB-4gsoA:
13.19
6dlzC-4gsoA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4gso THROMBIN-LIKE ENZYME
BJUSSUSP-1
(Bothrops
jararacussu) 		5 / 11 ILE A  89
PRO A  67
SER A  43
SER A  20
LEU A  27
 None
 1.29A 6dlzA-4gsoA:
undetectable
6dlzD-4gsoA:
undetectable		 6dlzA-4gsoA:
13.19
6dlzD-4gsoA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4gso THROMBIN-LIKE ENZYME
BJUSSUSP-1
(Bothrops
jararacussu) 		5 / 10 SER A  20
LEU A  27
ILE A  89
PRO A  67
SER A  43
 None
 1.42A 6dm1B-4gsoA:
undetectable
6dm1C-4gsoA:
undetectable		 6dm1B-4gsoA:
13.19
6dm1C-4gsoA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4gso THROMBIN-LIKE ENZYME
BJUSSUSP-1
(Bothrops
jararacussu) 		5 / 11 ILE A  89
PRO A  67
SER A  43
SER A  20
LEU A  27
 None
 1.30A 6dm1A-4gsoA:
undetectable
6dm1D-4gsoA:
undetectable		 6dm1A-4gsoA:
13.19
6dm1D-4gsoA:
13.19