SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gsw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 4gsw UBIQUITIN
(Entamoeba
histolytica) 		5 / 12 ILE A   6
THR A  10
PHE A  48
LEU A  46
ILE A  33
 None
 0.95A 2cd2A-4gswA:
undetectable		 2cd2A-4gswA:
18.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FCN_A_DVAA35_0
(UBIQUITIN)		 4gsw UBIQUITIN
(Entamoeba
histolytica) 		4 / 4 GLN A  34
GLU A  37
ILE A  39
PRO A  40
 None
 0.86A 2fcnA-4gswA:
15.5		 2fcnA-4gswA:
83.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FCN_B_DVAB35_0
(UBIQUITIN)		 4gsw UBIQUITIN
(Entamoeba
histolytica) 		4 / 6 GLN A  34
GLU A  37
ILE A  39
PRO A  40
 None
 0.70A 2fcnA-4gswA:
15.5
2fcnB-4gswA:
16.2		 2fcnA-4gswA:
83.54
2fcnB-4gswA:
83.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SU9_A_ACTA426_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4gsw UBIQUITIN
(Entamoeba
histolytica) 		3 / 3 GLN A  44
GLU A  55
LYS A  30
 None
 1.21A 3su9A-4gswA:
undetectable		 3su9A-4gswA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MGH_A_ACTA1320_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 4gsw UBIQUITIN
(Entamoeba
histolytica) 		4 / 5 VAL A  73
ILE A  47
LEU A  46
ARG A  45
 None
 0.87A 4mghA-4gswA:
undetectable		 4mghA-4gswA:
5.23