SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gt2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_1
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 4gt2 PUTATIVE
UNCHARACTERIZED
PROTEIN SCO3963
(Streptomyces
coelicolor) 		4 / 7 GLN B  95
THR B 151
SER B 149
TRP B 393
 None
 1.05A 1eiiA-4gt2B:
undetectable		 1eiiA-4gt2B:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)		 4gt2 PUTATIVE
UNCHARACTERIZED
PROTEIN SCO3963
(Streptomyces
coelicolor) 		4 / 8 ARG B 163
PHE B 161
GLY B 162
PHE B 426
 None
 0.90A 1fapB-4gt2B:
undetectable		 1fapB-4gt2B:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_A_8MOA501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4gt2 PUTATIVE
UNCHARACTERIZED
PROTEIN SCO3963
(Streptomyces
coelicolor) 		5 / 11 PHE B 390
VAL B 290
GLY B 400
LEU B 177
PHE B 180
 HEM  B 501 (-3.9A)
None
None
None
None
 0.83A 1z11A-4gt2B:
undetectable		 1z11A-4gt2B:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4gt2 PUTATIVE
UNCHARACTERIZED
PROTEIN SCO3963
(Streptomyces
coelicolor) 		5 / 10 PHE B 390
VAL B 290
GLY B 400
LEU B 177
PHE B 180
 HEM  B 501 (-3.9A)
None
None
None
None
 0.85A 1z11C-4gt2B:
undetectable		 1z11C-4gt2B:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4gt2 PUTATIVE
UNCHARACTERIZED
PROTEIN SCO3963
(Streptomyces
coelicolor) 		5 / 10 PHE B 390
VAL B 290
GLY B 400
LEU B 177
PHE B 180
 HEM  B 501 (-3.9A)
None
None
None
None
 0.85A 1z11D-4gt2B:
undetectable		 1z11D-4gt2B:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B9E_A_SAMA1201_0
(NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2)		 4gt2 PUTATIVE
UNCHARACTERIZED
PROTEIN SCO3963
(Streptomyces
coelicolor) 		5 / 12 ASN B 228
LEU B 185
ASP B 186
ARG B 189
ASP B 183
 None
 1.49A 2b9eA-4gt2B:
undetectable		 2b9eA-4gt2B:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ITA_D_AICD501_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACC)		 4gt2 PUTATIVE
UNCHARACTERIZED
PROTEIN SCO3963
(Streptomyces
coelicolor) 		3 / 3 PRO B  88
PHE B 154
ALA B 125
 None
 0.59A 3itaD-4gt2B:
undetectable		 3itaD-4gt2B:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO201_1
(PROTEIN S100-A4)		 4gt2 PUTATIVE
UNCHARACTERIZED
PROTEIN SCO3963
(Streptomyces
coelicolor) 		4 / 8 GLY B 155
PHE B 263
GLY B 286
PHE B 268
 None
 0.72A 3ko0O-4gt2B:
undetectable
3ko0Q-4gt2B:
undetectable		 3ko0O-4gt2B:
13.55
3ko0Q-4gt2B:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_C_DXCC92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4gt2 PUTATIVE
UNCHARACTERIZED
PROTEIN SCO3963
(Streptomyces
coelicolor) 		4 / 4 VAL B 291
PHE B 426
PHE B 154
VAL B 152
 None
 1.11A 3rv5C-4gt2B:
undetectable
3rv5D-4gt2B:
0.5		 3rv5C-4gt2B:
11.72
3rv5D-4gt2B:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA1001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 4gt2 PUTATIVE
UNCHARACTERIZED
PROTEIN SCO3963
(Streptomyces
coelicolor) 		4 / 5 LEU B 442
GLY B 439
PHE B 156
PHE B 160
 None
 1.02A 3smtA-4gt2B:
undetectable		 3smtA-4gt2B:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_A_9PLA501_1
(CYTOCHROME P450 2A6)		 4gt2 PUTATIVE
UNCHARACTERIZED
PROTEIN SCO3963
(Streptomyces
coelicolor) 		5 / 11 PHE B 390
VAL B 290
GLY B 400
LEU B 177
PHE B 180
 HEM  B 501 (-3.9A)
None
None
None
None
 0.75A 3t3rA-4gt2B:
undetectable		 3t3rA-4gt2B:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_C_SVRC516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 4gt2 PUTATIVE
UNCHARACTERIZED
PROTEIN SCO3963
(Streptomyces
coelicolor) 		5 / 9 PRO B 234
ALA B  96
ALA B 203
ASP B 202
ARG B  97
 GOL  B 505 ( 4.8A)
None
None
None
None
 1.45A 3ur0C-4gt2B:
undetectable		 3ur0C-4gt2B:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4gt2 PUTATIVE
UNCHARACTERIZED
PROTEIN SCO3963
(Streptomyces
coelicolor) 		5 / 12 LEU B 117
ALA B 432
PHE B  82
LEU B 210
THR B 124
 None
 1.14A 4iaqA-4gt2B:
undetectable		 4iaqA-4gt2B:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADE_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4gt2 PUTATIVE
UNCHARACTERIZED
PROTEIN SCO3963
(Streptomyces
coelicolor) 		4 / 6 VAL B 289
VAL B 368
TRP B 393
PHE B 268
 None
 1.49A 5adeA-4gt2B:
undetectable
5adeB-4gt2B:
undetectable		 5adeA-4gt2B:
20.77
5adeB-4gt2B:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4gt2 PUTATIVE
UNCHARACTERIZED
PROTEIN SCO3963
(Streptomyces
coelicolor) 		4 / 8 PHE B 390
PRO B 371
LEU B 389
LEU B 388
 HEM  B 501 (-3.9A)
None
None
HEM  B 501 ( 4.1A)
 0.98A 5dzkF-4gt2B:
undetectable
5dzkT-4gt2B:
undetectable		 5dzkF-4gt2B:
19.24
5dzkT-4gt2B:
3.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_A_010A609_0
(HNL ISOENZYME 5)		 4gt2 PUTATIVE
UNCHARACTERIZED
PROTEIN SCO3963
(Streptomyces
coelicolor) 		5 / 11 ALA B 221
VAL B 101
LEU B 194
LEU B 118
VAL B 196
 None
 1.09A 5eb5A-4gt2B:
1.4		 5eb5A-4gt2B:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 4gt2 PUTATIVE
UNCHARACTERIZED
PROTEIN SCO3963
(Streptomyces
coelicolor) 		5 / 12 ALA B 432
PHE B  82
THR B 151
GLN B 197
GLY B 155
 None
 1.25A 5m54E-4gt2B:
undetectable		 5m54E-4gt2B:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4gt2 PUTATIVE
UNCHARACTERIZED
PROTEIN SCO3963
(Streptomyces
coelicolor) 		3 / 3 GLN B 197
TRP B 195
VAL B 101
 None
 1.15A 6auuA-4gt2B:
undetectable		 6auuA-4gt2B:
20.04