SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gt6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		 4gt6 CELL SURFACE PROTEIN
(Faecalibacterium
prausnitzii) 		5 / 9 ASP A 258
ALA A 280
GLU A 283
SER A 304
VAL A 303
 None
 1.28A 1bcuH-4gt6A:
undetectable		 1bcuH-4gt6A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ESW_A_ACRA652_1
(AMYLOMALTASE)		 4gt6 CELL SURFACE PROTEIN
(Faecalibacterium
prausnitzii) 		4 / 6 TYR A 184
GLY A 207
GLY A 180
SER A 228
 None
EDO  A 906 ( 4.7A)
None
EDO  A 905 (-2.6A)
 0.79A 1eswA-4gt6A:
undetectable		 1eswA-4gt6A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1501_0
(FERROCHELATASE)		 4gt6 CELL SURFACE PROTEIN
(Faecalibacterium
prausnitzii) 		5 / 12 PHE A 136
LEU A 165
ILE A  97
VAL A 191
VAL A 151
 None
None
None
EDO  A 908 (-4.5A)
None
 1.21A 1hrkA-4gt6A:
undetectable		 1hrkA-4gt6A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2501_0
(FERROCHELATASE)		 4gt6 CELL SURFACE PROTEIN
(Faecalibacterium
prausnitzii) 		5 / 12 PHE A 136
LEU A 165
ILE A  97
VAL A 191
VAL A 151
 None
None
None
EDO  A 908 (-4.5A)
None
 1.31A 1hrkB-4gt6A:
undetectable		 1hrkB-4gt6A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7R_A_NCTA440_1
(CYTOCHROME P450-CAM)		 4gt6 CELL SURFACE PROTEIN
(Faecalibacterium
prausnitzii) 		4 / 7 VAL A 279
VAL A 249
ASP A 247
ILE A 246
 None
 0.98A 1p7rA-4gt6A:
undetectable		 1p7rA-4gt6A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_B_CAMB1416_0
(CYTOCHROME P450-CAM)		 4gt6 CELL SURFACE PROTEIN
(Faecalibacterium
prausnitzii) 		4 / 8 THR A 208
LEU A 188
VAL A 168
VAL A 177
 None
 1.14A 1uyuB-4gt6A:
undetectable		 1uyuB-4gt6A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_1
(POL POLYPROTEIN)		 4gt6 CELL SURFACE PROTEIN
(Faecalibacterium
prausnitzii) 		5 / 9 LEU A 148
ILE A  80
GLY A 105
VAL A 151
ILE A 147
 None
 1.11A 2avoA-4gt6A:
undetectable		 2avoA-4gt6A:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_A_THRA401_0
(ASPARTOKINASE)		 4gt6 CELL SURFACE PROTEIN
(Faecalibacterium
prausnitzii) 		4 / 8 GLY A 223
GLU A 202
ALA A 226
ILE A 200
 EDO  A 904 (-4.6A)
None
EDO  A 904 ( 4.9A)
None
 0.86A 2dtjA-4gt6A:
undetectable
2dtjB-4gt6A:
undetectable		 2dtjA-4gt6A:
19.44
2dtjB-4gt6A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBM_A_CAMA517_0
(CYTOCHROME P450-CAM)		 4gt6 CELL SURFACE PROTEIN
(Faecalibacterium
prausnitzii) 		4 / 8 PHE A 159
VAL A 151
VAL A 118
ILE A 145
 None
 0.91A 2qbmA-4gt6A:
undetectable		 2qbmA-4gt6A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB6_0
(FERROCHELATASE)		 4gt6 CELL SURFACE PROTEIN
(Faecalibacterium
prausnitzii) 		5 / 12 PHE A 136
LEU A 165
ILE A  97
VAL A 191
VAL A 151
 None
None
None
EDO  A 908 (-4.5A)
None
 1.27A 3aqiB-4gt6A:
undetectable		 3aqiB-4gt6A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_2
(PROTEASE)		 4gt6 CELL SURFACE PROTEIN
(Faecalibacterium
prausnitzii) 		5 / 9 VAL A 128
ILE A 104
ILE A  52
PRO A  98
THR A 100
 None
 1.22A 3el4B-4gt6A:
undetectable		 3el4B-4gt6A:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM201_1
(PROTEIN S100-A4)		 4gt6 CELL SURFACE PROTEIN
(Faecalibacterium
prausnitzii) 		4 / 7 GLY A  81
CYH A 139
PHE A 138
GLY A 132
 None
 0.98A 3ko0M-4gt6A:
undetectable
3ko0P-4gt6A:
undetectable		 3ko0M-4gt6A:
14.72
3ko0P-4gt6A:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO201_1
(PROTEIN S100-A4)		 4gt6 CELL SURFACE PROTEIN
(Faecalibacterium
prausnitzii) 		4 / 8 GLY A  81
CYH A 139
PHE A 138
GLY A 132
 None
 0.96A 3ko0O-4gt6A:
undetectable
3ko0Q-4gt6A:
undetectable		 3ko0O-4gt6A:
14.72
3ko0Q-4gt6A:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP201_1
(PROTEIN S100-A4)		 4gt6 CELL SURFACE PROTEIN
(Faecalibacterium
prausnitzii) 		4 / 7 GLY A 132
GLY A  81
CYH A 139
PHE A 138
 None
 0.93A 3ko0M-4gt6A:
undetectable
3ko0P-4gt6A:
undetectable		 3ko0M-4gt6A:
14.72
3ko0P-4gt6A:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_A_URFA2001_1
(URIDINE
PHOSPHORYLASE)		 4gt6 CELL SURFACE PROTEIN
(Faecalibacterium
prausnitzii) 		5 / 10 THR A 208
GLU A 229
LEU A 210
LEU A 233
ILE A 213
 None
EDO  A 905 ( 3.6A)
EDO  A 908 ( 4.8A)
None
EDO  A 908 (-3.0A)
 1.25A 3kvrA-4gt6A:
undetectable		 3kvrA-4gt6A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_2
(HIV-1 PROTEASE)		 4gt6 CELL SURFACE PROTEIN
(Faecalibacterium
prausnitzii) 		6 / 11 ALA A 355
ILE A 342
ILE A 325
PRO A 368
VAL A 371
ILE A 351
 None
 1.40A 3lzvB-4gt6A:
undetectable		 3lzvB-4gt6A:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_1
(PROTEASE)		 4gt6 CELL SURFACE PROTEIN
(Faecalibacterium
prausnitzii) 		6 / 10 ALA A 355
ILE A 342
ILE A 325
PRO A 368
VAL A 371
ILE A 351
 None
 1.36A 3nujA-4gt6A:
undetectable		 3nujA-4gt6A:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAY_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4gt6 CELL SURFACE PROTEIN
(Faecalibacterium
prausnitzii) 		5 / 10 ARG A 221
THR A 198
VAL A 177
GLU A 201
ILE A 170
 None
 1.41A 3uayA-4gt6A:
undetectable		 3uayA-4gt6A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4gt6 CELL SURFACE PROTEIN
(Faecalibacterium
prausnitzii) 		5 / 12 PHE A 136
LEU A 165
ILE A  97
VAL A 191
VAL A 151
 None
None
None
EDO  A 908 (-4.5A)
None
 1.25A 3w1wA-4gt6A:
undetectable		 3w1wA-4gt6A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4gt6 CELL SURFACE PROTEIN
(Faecalibacterium
prausnitzii) 		5 / 12 PHE A 136
LEU A 165
ILE A  97
VAL A 191
VAL A 151
 None
None
None
EDO  A 908 (-4.5A)
None
 1.29A 3w1wB-4gt6A:
undetectable		 3w1wB-4gt6A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 4gt6 CELL SURFACE PROTEIN
(Faecalibacterium
prausnitzii) 		5 / 12 PRO A  76
PRO A  98
ILE A 104
VAL A 128
ILE A 120
 None
None
None
None
EDO  A 911 (-4.2A)
 1.42A 4eb6B-4gt6A:
undetectable
4eb6C-4gt6A:
undetectable		 4eb6B-4gt6A:
22.15
4eb6C-4gt6A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		 4gt6 CELL SURFACE PROTEIN
(Faecalibacterium
prausnitzii) 		5 / 11 ILE A 170
ILE A 200
ALA A 204
THR A 208
VAL A 168
 None
 0.97A 4h1nA-4gt6A:
undetectable		 4h1nA-4gt6A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLT_A_8PRA505_1
(CYTOCHROME P450 2B4)		 4gt6 CELL SURFACE PROTEIN
(Faecalibacterium
prausnitzii) 		4 / 8 ILE A  80
GLU A  59
ALA A 108
VAL A  95
 None
 0.76A 4jltA-4gt6A:
undetectable		 4jltA-4gt6A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_B_RTLB201_0
(RETINOL-BINDING
PROTEIN 2)		 4gt6 CELL SURFACE PROTEIN
(Faecalibacterium
prausnitzii) 		5 / 12 PHE A 227
ILE A 215
LEU A 193
LEU A 188
LEU A 210
 None
None
EDO  A 908 (-4.3A)
None
EDO  A 908 ( 4.8A)
 1.33A 4qynB-4gt6A:
undetectable		 4qynB-4gt6A:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP1_A_LDPA708_1
(DOPAMINE
TRANSPORTER, ISOFORM
B)		 4gt6 CELL SURFACE PROTEIN
(Faecalibacterium
prausnitzii) 		5 / 10 ALA A 204
VAL A 177
PHE A 182
SER A 156
GLY A 180
 None
 1.18A 4xp1A-4gt6A:
undetectable		 4xp1A-4gt6A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4gt6 CELL SURFACE PROTEIN
(Faecalibacterium
prausnitzii) 		4 / 7 ILE A 305
LEU A 293
ILE A 275
MET A 298
 None
 0.88A 4xumA-4gt6A:
undetectable		 4xumA-4gt6A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4gt6 CELL SURFACE PROTEIN
(Faecalibacterium
prausnitzii) 		4 / 6 PHE A 333
VAL A 332
MET A 298
ILE A 325
 None
 1.17A 5iwuA-4gt6A:
undetectable		 5iwuA-4gt6A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_1
(PROTEASE E35D-APV)		 4gt6 CELL SURFACE PROTEIN
(Faecalibacterium
prausnitzii) 		6 / 9 ALA A 355
ILE A 342
ILE A 325
PRO A 368
VAL A 371
ILE A 351
 None
 1.40A 5kr0A-4gt6A:
undetectable		 5kr0A-4gt6A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_2
(PROTEASE PR5-SQV)		 4gt6 CELL SURFACE PROTEIN
(Faecalibacterium
prausnitzii) 		5 / 9 LEU A 148
ILE A  80
GLY A 105
VAL A 151
ILE A 147
 None
 1.15A 5kr2D-4gt6A:
undetectable		 5kr2D-4gt6A:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGK_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4gt6 CELL SURFACE PROTEIN
(Faecalibacterium
prausnitzii) 		3 / 3 VAL A  84
TYR A  40
GLN A  41
 None
None
EDO  A 901 ( 3.6A)
 0.76A 5qgkA-4gt6A:
undetectable		 5qgkA-4gt6A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGT_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4gt6 CELL SURFACE PROTEIN
(Faecalibacterium
prausnitzii) 		3 / 3 VAL A  84
TYR A  40
GLN A  41
 None
None
EDO  A 901 ( 3.6A)
 0.73A 5qgtA-4gt6A:
undetectable		 5qgtA-4gt6A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_A_MTXA402_1
(THYMIDYLATE SYNTHASE)		 4gt6 CELL SURFACE PROTEIN
(Faecalibacterium
prausnitzii) 		5 / 12 PHE A 159
ILE A 154
ASP A 179
GLY A 180
PHE A 182
 None
 1.16A 5x66A-4gt6A:
undetectable
5x66B-4gt6A:
undetectable		 5x66A-4gt6A:
23.11
5x66B-4gt6A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 4gt6 CELL SURFACE PROTEIN
(Faecalibacterium
prausnitzii) 		5 / 10 PHE A 159
ILE A 154
ASP A 179
GLY A 180
PHE A 182
 None
 1.18A 5x66D-4gt6A:
undetectable		 5x66D-4gt6A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_A_SAMA505_0
(CARNOSINE
N-METHYLTRANSFERASE)		 4gt6 CELL SURFACE PROTEIN
(Faecalibacterium
prausnitzii) 		5 / 12 GLY A 358
ASN A 381
SER A 377
CYH A 336
PHE A 333
 None
 1.46A 5yf0A-4gt6A:
undetectable		 5yf0A-4gt6A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_B_SAMB503_0
(CARNOSINE
N-METHYLTRANSFERASE)		 4gt6 CELL SURFACE PROTEIN
(Faecalibacterium
prausnitzii) 		5 / 12 GLY A 358
ASN A 381
SER A 377
CYH A 336
PHE A 333
 None
 1.47A 5yf0B-4gt6A:
0.0		 5yf0B-4gt6A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4gt6 CELL SURFACE PROTEIN
(Faecalibacterium
prausnitzii) 		5 / 12 ILE A 213
LEU A 188
PHE A 205
ILE A 170
THR A 211
 EDO  A 908 (-3.0A)
None
EDO  A 908 ( 4.2A)
None
None
 1.23A 5z6fA-4gt6A:
undetectable		 5z6fA-4gt6A:
18.63