SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gt7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_D_IMND476_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 4gt7 IG EPSILON CHAIN C
REGION
(Homo
sapiens) 		5 / 12 THR A 493
PRO A 495
ILE A 474
VAL A 476
VAL A 505
 None
 1.18A 1z9hD-4gt7A:
undetectable		 1z9hD-4gt7A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)		 4gt7 IG EPSILON CHAIN C
REGION
(Homo
sapiens) 		4 / 5 ILE A 474
SER A 475
PRO A 345
PHE A 346
 None
 1.34A 3bjwC-4gt7A:
undetectable		 3bjwC-4gt7A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_A_CCSA109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 4gt7 IG EPSILON CHAIN C
REGION
(Homo
sapiens) 		4 / 8 PHE A 503
HIS A 528
ILE A 474
ALA A 531
 None
 0.89A 4eyzA-4gt7A:
undetectable		 4eyzA-4gt7A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_B_CCSB109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 4gt7 IG EPSILON CHAIN C
REGION
(Homo
sapiens) 		4 / 8 PHE A 503
HIS A 528
ILE A 474
ALA A 531
 None
 0.89A 4eyzB-4gt7A:
undetectable		 4eyzB-4gt7A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA609_0
(NADH DEHYDROGENASE,
PUTATIVE)		 4gt7 IG EPSILON CHAIN C
REGION
(Homo
sapiens) 		3 / 3 VAL A 382
SER A 375
TRP A 374
 None
 0.98A 5jwaA-4gt7A:
undetectable		 5jwaA-4gt7A:
17.58