SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gtn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3003_1
(SERUM ALBUMIN)		 4gtn ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Acinetobacter
sp.
ADP1) 		4 / 6 PHE A 359
ILE A 151
LYS A 361
LYS A 364
 None
 1.15A 1hk2A-4gtnA:
undetectable		 1hk2A-4gtnA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA155_1
(CALMODULIN)		 4gtn ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Acinetobacter
sp.
ADP1) 		4 / 7 GLN A  25
PHE A 197
MET A  41
ALA A  39
 None
 1.28A 1linA-4gtnA:
undetectable		 1linA-4gtnA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_1
(PROTEASE)		 4gtn ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Acinetobacter
sp.
ADP1) 		4 / 7 GLY A  59
ILE A  58
ALA A  26
ILE A  30
 None
 0.60A 1n49A-4gtnA:
undetectable		 1n49A-4gtnA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		 4gtn ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Acinetobacter
sp.
ADP1) 		3 / 3 ASP A 244
GLU A 273
TYR A 333
 None
 0.80A 1wsvA-4gtnA:
undetectable		 1wsvA-4gtnA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 4gtn ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Acinetobacter
sp.
ADP1) 		5 / 11 LEU A 199
ILE A 225
HIS A 241
ASP A 106
GLY A 105
 None
 1.14A 1zz1A-4gtnA:
undetectable		 1zz1A-4gtnA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_P1ZA2002_1
(SERUM ALBUMIN)		 4gtn ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Acinetobacter
sp.
ADP1) 		5 / 12 LEU A 285
PHE A 111
LEU A 251
ILE A 316
ALA A 313
 None
 0.99A 2bxqA-4gtnA:
undetectable		 2bxqA-4gtnA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H77_A_T3A1_1
(THRA PROTEIN)		 4gtn ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Acinetobacter
sp.
ADP1) 		5 / 12 ILE A 196
ALA A  78
MET A  45
LEU A  36
ILE A  23
 None
 1.00A 2h77A-4gtnA:
undetectable		 2h77A-4gtnA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		 4gtn ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Acinetobacter
sp.
ADP1) 		4 / 7 ILE A 308
SER A 306
ILE A 316
PHE A 111
 None
 1.14A 2q6hA-4gtnA:
undetectable		 2q6hA-4gtnA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA802_1
(TRANSPORTER)		 4gtn ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Acinetobacter
sp.
ADP1) 		4 / 6 ILE A 308
SER A 306
ILE A 316
PHE A 111
 None
 1.13A 2q72A-4gtnA:
undetectable		 2q72A-4gtnA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		 4gtn ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Acinetobacter
sp.
ADP1) 		4 / 7 ILE A 308
SER A 306
ILE A 316
PHE A 111
 None
 1.13A 2qb4A-4gtnA:
undetectable		 2qb4A-4gtnA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 4gtn ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Acinetobacter
sp.
ADP1) 		5 / 12 VAL A 113
SER A 250
SER A 253
VAL A 240
GLY A 215
 None
 1.25A 2x2iA-4gtnA:
undetectable		 2x2iA-4gtnA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 4gtn ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Acinetobacter
sp.
ADP1) 		4 / 6 LEU A  36
ARG A  46
MET A  45
VAL A 216
 None
 0.98A 2ygoA-4gtnA:
undetectable		 2ygoA-4gtnA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4gtn ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Acinetobacter
sp.
ADP1) 		5 / 12 ALA A 349
GLY A 346
GLY A 347
ILE A 277
ALA A 317
 None
 0.73A 3douA-4gtnA:
undetectable		 3douA-4gtnA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_D_T44D328_1
(5-HYDROXYISOURATE
HYDROLASE)		 4gtn ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Acinetobacter
sp.
ADP1) 		5 / 9 LEU A 301
THR A 115
LEU A 146
LEU A 145
SER A 293
 None
 1.36A 3q1eB-4gtnA:
undetectable
3q1eD-4gtnA:
undetectable		 3q1eB-4gtnA:
16.72
3q1eD-4gtnA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4gtn ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Acinetobacter
sp.
ADP1) 		4 / 8 ILE A 257
LEU A 270
VAL A 337
GLY A 336
 None
 0.90A 3w1wA-4gtnA:
3.3		 3w1wA-4gtnA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_A_SALA601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4gtn ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Acinetobacter
sp.
ADP1) 		4 / 7 LEU A 155
THR A 360
ILE A 151
GLY A 170
 None
 0.91A 4eq4A-4gtnA:
undetectable		 4eq4A-4gtnA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4gtn ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Acinetobacter
sp.
ADP1) 		4 / 7 LEU A 155
THR A 360
ILE A 151
GLY A 170
 None
 0.89A 4eqlA-4gtnA:
undetectable		 4eqlA-4gtnA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4gtn ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Acinetobacter
sp.
ADP1) 		4 / 7 ASN A 205
GLY A 208
VAL A 209
ILE A  94
 None
 0.77A 4fglC-4gtnA:
undetectable		 4fglC-4gtnA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_B_AERB602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4gtn ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Acinetobacter
sp.
ADP1) 		5 / 9 ALA A 124
ILE A 100
VAL A 213
GLY A 321
VAL A 326
 None
 1.31A 4r20B-4gtnA:
undetectable		 4r20B-4gtnA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_B_NOVB2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 4gtn ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Acinetobacter
sp.
ADP1) 		5 / 11 ASP A  90
GLU A 161
MET A 157
ILE A  87
THR A 160
 None
 1.22A 4urnB-4gtnA:
undetectable		 4urnB-4gtnA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_C_NOVC2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 4gtn ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Acinetobacter
sp.
ADP1) 		5 / 11 ASP A  90
GLU A 161
MET A 157
ILE A  87
THR A 160
 None
 1.20A 4urnC-4gtnA:
undetectable		 4urnC-4gtnA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_2
(CYP51 VARIANT1)		 4gtn ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Acinetobacter
sp.
ADP1) 		3 / 3 PRO A 272
ILE A 343
SER A 253
 None
 0.61A 5fsaA-4gtnA:
undetectable		 5fsaA-4gtnA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_A_SAMA801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 4gtn ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Acinetobacter
sp.
ADP1) 		5 / 12 ILE A  30
ALA A  26
LEU A  61
GLU A  74
VAL A  44
 None
 1.13A 5hw4A-4gtnA:
undetectable		 5hw4A-4gtnA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_C_SAMC801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 4gtn ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Acinetobacter
sp.
ADP1) 		5 / 12 ILE A  30
ALA A  26
LEU A  61
GLU A  74
VAL A  44
 None
 1.11A 5hw4C-4gtnA:
undetectable		 5hw4C-4gtnA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_2
(EPHRIN TYPE-A
RECEPTOR 2)		 4gtn ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Acinetobacter
sp.
ADP1) 		3 / 3 ILE A 214
ILE A 257
MET A 229
 None
 0.66A 5i9yA-4gtnA:
undetectable		 5i9yA-4gtnA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4gtn ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE
(Acinetobacter
sp.
ADP1) 		5 / 12 ILE A 344
GLY A 347
GLU A 248
ALA A 124
PHE A 111
 None
 1.10A 5igyA-4gtnA:
undetectable		 5igyA-4gtnA:
23.71