SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gtr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4gtr PROTEIN
FARNESYLTRANSFERASE/
GERANYLGERANYLTRANSF
ERASE TYPE-1 SUBUNIT
ALPHA
(Rattus
norvegicus) 		4 / 6 ILE A 267
TRP A 277
PHE A 314
GLU A 274
 None
 1.48A 1nsiA-4gtrA:
undetectable
1nsiB-4gtrA:
undetectable		 1nsiA-4gtrA:
19.12
1nsiB-4gtrA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4gtr PROTEIN
FARNESYLTRANSFERASE/
GERANYLGERANYLTRANSF
ERASE TYPE-1 SUBUNIT
ALPHA
(Rattus
norvegicus) 		4 / 6 TRP A 277
PHE A 314
GLU A 274
ILE A 267
 None
 1.46A 1nsiC-4gtrA:
undetectable
1nsiD-4gtrA:
undetectable		 1nsiC-4gtrA:
19.12
1nsiD-4gtrA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4gtr PROTEIN
FARNESYLTRANSFERASE/
GERANYLGERANYLTRANSF
ERASE TYPE-1 SUBUNIT
ALPHA
(Rattus
norvegicus) 		4 / 7 ILE A 267
TRP A 277
PHE A 314
GLU A 274
 None
 1.48A 3e7gA-4gtrA:
undetectable
3e7gB-4gtrA:
undetectable		 3e7gA-4gtrA:
18.69
3e7gB-4gtrA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_B_H4BB1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4gtr PROTEIN
FARNESYLTRANSFERASE/
GERANYLGERANYLTRANSF
ERASE TYPE-1 SUBUNIT
ALPHA
(Rattus
norvegicus) 		4 / 7 TRP A 277
PHE A 314
GLU A 274
ILE A 267
 None
 1.48A 3e7gA-4gtrA:
undetectable
3e7gB-4gtrA:
undetectable		 3e7gA-4gtrA:
18.69
3e7gB-4gtrA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_D_H4BD600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4gtr PROTEIN
FARNESYLTRANSFERASE/
GERANYLGERANYLTRANSF
ERASE TYPE-1 SUBUNIT
ALPHA
(Rattus
norvegicus) 		4 / 7 TRP A 277
PHE A 314
GLU A 274
ILE A 267
 None
 1.43A 4cx7C-4gtrA:
undetectable
4cx7D-4gtrA:
undetectable		 4cx7C-4gtrA:
19.12
4cx7D-4gtrA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_D_ACTD403_0
(D-ALANINE--D-ALANINE
LIGASE)		 4gtr PROTEIN
FARNESYLTRANSFERASE/
GERANYLGERANYLTRANSF
ERASE TYPE-1 SUBUNIT
ALPHA
(Rattus
norvegicus) 		4 / 6 TYR A 292
ARG A 253
SER A 251
LEU A 256
 None
 1.29A 5bphD-4gtrA:
undetectable		 5bphD-4gtrA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA617_0
(SERUM ALBUMIN)		 4gtr PROTEIN
FARNESYLTRANSFERASE/
GERANYLGERANYLTRANSF
ERASE TYPE-1 SUBUNIT
ALPHA
(Rattus
norvegicus) 		3 / 3 TRP A 237
ARG A 240
LEU A 280
 None
 0.99A 5dbyA-4gtrA:
undetectable		 5dbyA-4gtrA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA301_1
(CHITOSANASE)		 4gtr PROTEIN
FARNESYLTRANSFERASE/
GERANYLGERANYLTRANSF
ERASE TYPE-1 SUBUNIT
ALPHA
(Rattus
norvegicus) 		4 / 8 GLN A 364
ARG A 357
GLY A 360
LEU A 338
 None
 1.02A 5hwaA-4gtrA:
undetectable		 5hwaA-4gtrA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_2
(CYTOCHROME P450 2C9)		 4gtr PROTEIN
FARNESYLTRANSFERASE/
GERANYLGERANYLTRANSF
ERASE TYPE-1 SUBUNIT
ALPHA
(Rattus
norvegicus) 		3 / 3 LEU A 363
VAL A 316
ASP A 317
 None
 0.53A 5x23A-4gtrA:
undetectable		 5x23A-4gtrA:
21.22