SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gtu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_B_D16B415_1
(THYMIDYLATE SYNTHASE)		 4gtu GLUTATHIONE
S-TRANSFERASE
(Homo
sapiens) 		5 / 12 ILE A 168
GLY A 215
TYR A 115
LYS A 123
ALA A 111
 None
 1.05A 1hvyB-4gtuA:
undetectable		 1hvyB-4gtuA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_L_AG2L7014_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 4gtu GLUTATHIONE
S-TRANSFERASE
(Homo
sapiens) 		4 / 7 LEU A  20
LEU A  76
ILE A  69
MET A   2
 None
 1.04A 1n13I-4gtuA:
undetectable
1n13L-4gtuA:
undetectable		 1n13I-4gtuA:
16.06
1n13L-4gtuA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		 4gtu GLUTATHIONE
S-TRANSFERASE
(Homo
sapiens) 		4 / 8 SER A  25
LEU A  20
LEU A  62
ASP A  64
 None
 1.10A 2j2pA-4gtuA:
undetectable
2j2pB-4gtuA:
undetectable		 2j2pA-4gtuA:
19.76
2j2pB-4gtuA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_B_SFYB806_0
(SEPIAPTERIN
REDUCTASE)		 4gtu GLUTATHIONE
S-TRANSFERASE
(Homo
sapiens) 		5 / 11 LEU A 207
CYH A 114
PHE A 119
TRP A 214
TYR A 208
 None
 1.43A 4hwkB-4gtuA:
undetectable		 4hwkB-4gtuA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_C_SFYC804_0
(SEPIAPTERIN
REDUCTASE)		 4gtu GLUTATHIONE
S-TRANSFERASE
(Homo
sapiens) 		5 / 12 LEU A 207
CYH A 114
PHE A 119
TRP A 214
TYR A 208
 None
 1.43A 4hwkC-4gtuA:
undetectable		 4hwkC-4gtuA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA602_1
(SERUM ALBUMIN)		 4gtu GLUTATHIONE
S-TRANSFERASE
(Homo
sapiens) 		5 / 9 PHE A 157
ALA A  15
ALA A  13
LEU A 203
LEU A  19
 None
 1.24A 4or0A-4gtuA:
undetectable		 4or0A-4gtuA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_1
(CYTOCHROME P450 3A4)		 4gtu GLUTATHIONE
S-TRANSFERASE
(Homo
sapiens) 		5 / 12 PHE A 202
ASP A 164
PHE A 157
ILE A 152
ALA A 195
 None
 1.24A 5vcgA-4gtuA:
undetectable		 5vcgA-4gtuA:
18.35