SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gtv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD8_0
(GRAMICIDIN A)		 4gtv GERANYLGERANYL
TRANSFERASE TYPE-2
SUBUNIT ALPHA
(Rattus
norvegicus) 		3 / 3 VAL A 152
VAL A 158
TRP A 125
 None
 0.93A 1av2C-4gtvA:
undetectable
1av2D-4gtvA:
undetectable		 1av2C-4gtvA:
4.03
1av2D-4gtvA:
4.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		 4gtv GERANYLGERANYL
TRANSFERASE TYPE-2
SUBUNIT ALPHA
(Rattus
norvegicus) 		4 / 8 GLU A 128
ARG A 127
HIS A 112
LEU A  96
 None
 1.04A 1cmaA-4gtvA:
undetectable
1cmaB-4gtvA:
undetectable		 1cmaA-4gtvA:
15.20
1cmaB-4gtvA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R3A_A_SAMA304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2)		 4gtv GERANYLGERANYL
TRANSFERASE TYPE-2
SUBUNIT ALPHA
(Rattus
norvegicus) 		5 / 12 THR A 299
TYR A 296
CYH A 273
CYH A 260
LEU A 274
 None
 1.36A 2r3aA-4gtvA:
undetectable		 2r3aA-4gtvA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_F_TFPF202_1
(PROTEIN S100-A4)		 4gtv GERANYLGERANYL
TRANSFERASE TYPE-2
SUBUNIT ALPHA
(Rattus
norvegicus) 		5 / 11 GLU A 140
ASP A 139
LEU A 170
CYH A 145
PHE A 143
 None
 1.36A 3ko0E-4gtvA:
undetectable
3ko0F-4gtvA:
undetectable
3ko0G-4gtvA:
undetectable
3ko0H-4gtvA:
undetectable		 3ko0E-4gtvA:
14.42
3ko0F-4gtvA:
14.42
3ko0G-4gtvA:
14.42
3ko0H-4gtvA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA277_0
(UNIVERSAL STRESS
PROTEIN)		 4gtv GERANYLGERANYL
TRANSFERASE TYPE-2
SUBUNIT ALPHA
(Rattus
norvegicus) 		3 / 3 ASP A 225
SER A 227
ARG A 141
 None
 0.66A 3loqA-4gtvA:
undetectable		 3loqA-4gtvA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 4gtv GERANYLGERANYL
TRANSFERASE TYPE-2
SUBUNIT ALPHA
(Rattus
norvegicus) 		4 / 6 LEU A  56
ASN A  59
PRO A  60
ARG A 101
 None
 1.40A 4yv5A-4gtvA:
undetectable		 4yv5A-4gtvA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSN_A_MMZA503_1
(FLAVIN-CONTAINING
MONOOXYGENASE)		 4gtv GERANYLGERANYL
TRANSFERASE TYPE-2
SUBUNIT ALPHA
(Rattus
norvegicus) 		3 / 3 ASN A 177
SER A 180
SER A 179
 None
 0.75A 5gsnA-4gtvA:
undetectable		 5gsnA-4gtvA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_I_PACI1_0
(SERINE PROTEASE NS3
SERINE PROTEASE
SUBUNIT NS2B
PEPTIDE
PAC-DLY-DLY-DAR)		 4gtv GERANYLGERANYL
TRANSFERASE TYPE-2
SUBUNIT ALPHA
(Rattus
norvegicus) 		3 / 3 VAL A 215
TYR A 231
GLU A 256
 None
 0.66A 5zmqD-4gtvA:
undetectable
5zmqE-4gtvA:
undetectable		 5zmqD-4gtvA:
20.66
5zmqE-4gtvA:
11.21