SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gu3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4gu3 OUTER CAPSID PROTEIN
SIGMA-1
(Mammalian
orthoreovirus) 		3 / 3 ASN A 375
TRP A 350
GLN A 455
 None
 1.28A 1xoqA-4gu3A:
undetectable		 1xoqA-4gu3A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4gu3 OUTER CAPSID PROTEIN
SIGMA-1
(Mammalian
orthoreovirus) 		4 / 7 ILE A 463
LEU A 367
PHE A 369
ARG A 429
 None
 1.10A 2zxwN-4gu3A:
undetectable
2zxwW-4gu3A:
undetectable		 2zxwN-4gu3A:
17.29
2zxwW-4gu3A:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4gu3 OUTER CAPSID PROTEIN
SIGMA-1
(Mammalian
orthoreovirus) 		4 / 5 GLN A 344
PHE A 383
LEU A 441
PHE A 387
 None
 1.44A 3ablC-4gu3A:
undetectable
3ablJ-4gu3A:
undetectable		 3ablC-4gu3A:
23.27
3ablJ-4gu3A:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA604_0
(GBAA_1210 PROTEIN)		 4gu3 OUTER CAPSID PROTEIN
SIGMA-1
(Mammalian
orthoreovirus) 		4 / 6 TYR A 343
VAL A 456
HIS A 453
THR A 374
 None
 0.89A 3tj7A-4gu3A:
undetectable
3tj7B-4gu3A:
undetectable		 3tj7A-4gu3A:
21.99
3tj7B-4gu3A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA604_0
(GBAA_1210 PROTEIN)		 4gu3 OUTER CAPSID PROTEIN
SIGMA-1
(Mammalian
orthoreovirus) 		4 / 6 VAL A 456
HIS A 453
SER A 376
THR A 374
 None
 1.11A 3tj7A-4gu3A:
undetectable
3tj7B-4gu3A:
undetectable		 3tj7A-4gu3A:
21.99
3tj7B-4gu3A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC606_0
(GBAA_1210 PROTEIN)		 4gu3 OUTER CAPSID PROTEIN
SIGMA-1
(Mammalian
orthoreovirus) 		4 / 6 TYR A 343
VAL A 456
HIS A 453
THR A 374
 None
 0.88A 3tj7C-4gu3A:
undetectable
3tj7D-4gu3A:
undetectable		 3tj7C-4gu3A:
21.99
3tj7D-4gu3A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC606_0
(GBAA_1210 PROTEIN)		 4gu3 OUTER CAPSID PROTEIN
SIGMA-1
(Mammalian
orthoreovirus) 		4 / 6 VAL A 456
HIS A 453
SER A 376
THR A 374
 None
 1.08A 3tj7C-4gu3A:
undetectable
3tj7D-4gu3A:
undetectable		 3tj7C-4gu3A:
21.99
3tj7D-4gu3A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_D_ACTD605_0
(GBAA_1210 PROTEIN)		 4gu3 OUTER CAPSID PROTEIN
SIGMA-1
(Mammalian
orthoreovirus) 		4 / 6 VAL A 456
HIS A 453
SER A 376
THR A 374
 None
 1.07A 3tj7C-4gu3A:
undetectable
3tj7D-4gu3A:
undetectable		 3tj7C-4gu3A:
21.99
3tj7D-4gu3A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_D_ACTD605_0
(GBAA_1210 PROTEIN)		 4gu3 OUTER CAPSID PROTEIN
SIGMA-1
(Mammalian
orthoreovirus) 		4 / 6 VAL A 456
HIS A 453
THR A 374
TYR A 343
 None
 0.86A 3tj7C-4gu3A:
undetectable
3tj7D-4gu3A:
undetectable		 3tj7C-4gu3A:
21.99
3tj7D-4gu3A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_D_ACTD201_0
(RETINOL-BINDING
PROTEIN 2)		 4gu3 OUTER CAPSID PROTEIN
SIGMA-1
(Mammalian
orthoreovirus) 		3 / 3 ASP A 380
HIS A 345
LYS A 382
 None
 0.75A 4qzuD-4gu3A:
undetectable		 4qzuD-4gu3A:
19.73