SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gu7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_C_CCSC47_0
(GLUTATHIONE
S-TRANSFERASE)		 4gu7 PUTATIVE
UNCHARACTERIZED
PROTEIN SCO7193
(Streptomyces
coelicolor) 		4 / 6 TRP A  71
THR A 303
LEU A 104
GLY A  67
 None
 1.21A 1gtiC-4gu7A:
undetectable		 1gtiC-4gu7A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4G_A_RIOA500_0
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 4gu7 PUTATIVE
UNCHARACTERIZED
PROTEIN SCO7193
(Streptomyces
coelicolor) 		5 / 9 ASP A 217
GLU A 214
SER A 230
ARG A 276
ASP A 238
 None
HEM  A 401 ( 4.8A)
HEM  A 401 (-3.6A)
None
None
 1.45A 1m4gA-4gu7A:
0.0		 1m4gA-4gu7A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 4gu7 PUTATIVE
UNCHARACTERIZED
PROTEIN SCO7193
(Streptomyces
coelicolor) 		4 / 8 LEU A 104
TYR A 259
ILE A 261
TYR A 263
 None
 1.05A 1qvtA-4gu7A:
undetectable		 1qvtA-4gu7A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4gu7 PUTATIVE
UNCHARACTERIZED
PROTEIN SCO7193
(Streptomyces
coelicolor) 		3 / 3 LEU A 239
LEU A 228
MET A 277
 None
None
HEM  A 401 ( 3.8A)
 0.83A 2itzA-4gu7A:
undetectable		 2itzA-4gu7A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WM3_A_NFLA1301_1
(NMRA-LIKE FAMILY
DOMAIN CONTAINING
PROTEIN 1)		 4gu7 PUTATIVE
UNCHARACTERIZED
PROTEIN SCO7193
(Streptomyces
coelicolor) 		4 / 6 LEU A 126
PHE A 105
LEU A  24
ASP A 102
 None
 0.94A 2wm3A-4gu7A:
undetectable		 2wm3A-4gu7A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4gu7 PUTATIVE
UNCHARACTERIZED
PROTEIN SCO7193
(Streptomyces
coelicolor) 		4 / 8 ASP A  42
SER A  45
ASP A  38
ASP A 307
 None
 1.24A 3havA-4gu7A:
undetectable		 3havA-4gu7A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE201_1
(PROTEIN S100-A4)		 4gu7 PUTATIVE
UNCHARACTERIZED
PROTEIN SCO7193
(Streptomyces
coelicolor) 		4 / 7 PHE A 248
GLY A 138
PHE A 139
PHE A 256
 None
 1.09A 3ko0D-4gu7A:
undetectable
3ko0E-4gu7A:
undetectable		 3ko0D-4gu7A:
14.50
3ko0E-4gu7A:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_A_ADNA901_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4gu7 PUTATIVE
UNCHARACTERIZED
PROTEIN SCO7193
(Streptomyces
coelicolor) 		5 / 9 ALA A  49
GLY A  51
LEU A 118
LEU A 114
ILE A 107
 None
 1.41A 3wdmA-4gu7A:
undetectable		 3wdmA-4gu7A:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_B_CAMB1419_0
(CYTOCHROME P450)		 4gu7 PUTATIVE
UNCHARACTERIZED
PROTEIN SCO7193
(Streptomyces
coelicolor) 		6 / 12 ILE A  66
THR A  64
LEU A  39
VAL A  26
ILE A  28
VAL A 130
 None
 1.48A 4c9lB-4gu7A:
undetectable		 4c9lB-4gu7A:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4gu7 PUTATIVE
UNCHARACTERIZED
PROTEIN SCO7193
(Streptomyces
coelicolor) 		4 / 7 ALA A 165
ASP A 244
GLY A 153
GLU A 144
 None
None
HEM  A 401 (-3.4A)
None
 0.92A 5bs8A-4gu7A:
1.4
5bs8C-4gu7A:
1.5
5bs8D-4gu7A:
undetectable		 5bs8A-4gu7A:
23.19
5bs8C-4gu7A:
23.19
5bs8D-4gu7A:
26.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB202_0
(HYDROXYNITRILE LYASE)		 4gu7 PUTATIVE
UNCHARACTERIZED
PROTEIN SCO7193
(Streptomyces
coelicolor) 		4 / 7 VAL A  63
THR A 303
ARG A 108
VAL A 166
 None
 0.91A 5e4dA-4gu7A:
1.4
5e4dB-4gu7A:
1.5		 5e4dA-4gu7A:
22.67
5e4dB-4gu7A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA605_0
(ALPHA-AMYLASE)		 4gu7 PUTATIVE
UNCHARACTERIZED
PROTEIN SCO7193
(Streptomyces
coelicolor) 		4 / 8 TYR A 180
GLY A  65
ILE A  66
PRO A  85
 None
 0.82A 6ag0A-4gu7A:
undetectable		 6ag0A-4gu7A:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC605_0
(ALPHA-AMYLASE)		 4gu7 PUTATIVE
UNCHARACTERIZED
PROTEIN SCO7193
(Streptomyces
coelicolor) 		4 / 8 TYR A 180
GLY A  65
ILE A  66
PRO A  85
 None
 0.89A 6ag0C-4gu7A:
undetectable		 6ag0C-4gu7A:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_1
(-)		 4gu7 PUTATIVE
UNCHARACTERIZED
PROTEIN SCO7193
(Streptomyces
coelicolor) 		5 / 12 GLY A  31
GLY A  32
VAL A  36
ASP A 102
GLY A 128
 None
 1.13A 6gneA-4gu7A:
undetectable		 6gneA-4gu7A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_1
(-)		 4gu7 PUTATIVE
UNCHARACTERIZED
PROTEIN SCO7193
(Streptomyces
coelicolor) 		5 / 12 GLY A  31
GLY A  32
VAL A  36
ASP A 102
GLY A 128
 None
 1.13A 6gneB-4gu7A:
undetectable		 6gneB-4gu7A:
22.24