SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gua'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 4gua NON-STRUCTURAL
POLYPROTEIN
(Sindbis
virus) 		5 / 10 LEU A1475
ASN A1473
TYR A1351
LEU A1455
TYR A1436
 None
 1.24A 1fkoA-4guaA:
undetectable		 1fkoA-4guaA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_2
(PHOSPHOLIPASE A2
HOMOLOG 2)		 4gua NON-STRUCTURAL
POLYPROTEIN
(Sindbis
virus) 		5 / 11 LEU A1157
LEU A1161
VAL A1153
GLY A1070
HIS A1241
 None
 1.42A 1y4lB-4guaA:
undetectable		 1y4lB-4guaA:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA509_0
(CHORISMATE SYNTHASE)		 4gua NON-STRUCTURAL
POLYPROTEIN
(Sindbis
virus) 		3 / 3 ARG A1239
GLN A1048
PRO A1047
 None
 0.94A 2qhfA-4guaA:
undetectable		 2qhfA-4guaA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN0_A_TDZA501_1
(CYTOCHROME P450 2C8)		 4gua NON-STRUCTURAL
POLYPROTEIN
(Sindbis
virus) 		5 / 12 ILE A1488
THR A1353
LEU A1475
ASN A1473
GLU A1469
 None
 1.24A 2vn0A-4guaA:
undetectable		 2vn0A-4guaA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4gua NON-STRUCTURAL
POLYPROTEIN
(Sindbis
virus) 		5 / 12 ALA A1298
GLY A1344
GLY A1346
HIS A1329
VAL A1333
 None
 0.95A 3f8wA-4guaA:
2.5		 3f8wA-4guaA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_1
(YAEB-LIKE PROTEIN
RPA0152)		 4gua NON-STRUCTURAL
POLYPROTEIN
(Sindbis
virus) 		5 / 12 CYH A1474
PRO A1418
GLY A1400
THR A1401
LEU A1658
 None
 1.23A 3okxB-4guaA:
undetectable		 3okxB-4guaA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_B_SAMB6735_0
(16S RRNA METHYLASE)		 4gua NON-STRUCTURAL
POLYPROTEIN
(Sindbis
virus) 		5 / 12 GLY A1109
ALA A1025
LEU A1073
THR A1086
LEU A1085
 None
 1.14A 3p2kB-4guaA:
undetectable		 3p2kB-4guaA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4gua NON-STRUCTURAL
POLYPROTEIN
(Sindbis
virus) 		5 / 11 PRO A1389
ARG A1387
ILE A1384
VAL A1412
VAL A1366
 None
 1.22A 3rf4A-4guaA:
undetectable
3rf4C-4guaA:
undetectable		 3rf4A-4guaA:
10.84
3rf4C-4guaA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4gua NON-STRUCTURAL
POLYPROTEIN
(Sindbis
virus) 		5 / 11 PRO A1389
ARG A1387
ILE A1384
VAL A1412
VAL A1366
 None
 1.24A 3rf4A-4guaA:
undetectable
3rf4B-4guaA:
undetectable		 3rf4A-4guaA:
10.84
3rf4B-4guaA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4gua NON-STRUCTURAL
POLYPROTEIN
(Sindbis
virus) 		5 / 11 PRO A1389
ARG A1387
ILE A1384
VAL A1412
VAL A1366
 None
 1.18A 3rf4B-4guaA:
undetectable
3rf4C-4guaA:
undetectable		 3rf4B-4guaA:
10.84
3rf4C-4guaA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_B_NCAB1536_0
(DIPHTHERIA TOXIN)		 4gua NON-STRUCTURAL
POLYPROTEIN
(Sindbis
virus) 		4 / 5 HIS A1242
TYR A1275
TYR A1165
GLU A1309
 None
 1.42A 4ae1B-4guaA:
undetectable		 4ae1B-4guaA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_E_KANE301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4gua NON-STRUCTURAL
POLYPROTEIN
(Sindbis
virus) 		5 / 11 SER A1297
HIS A1329
ASP A1343
ASP A1485
ASN A1447
 None
 1.31A 4fevE-4guaA:
1.3		 4fevE-4guaA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_E_KANE301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4gua NON-STRUCTURAL
POLYPROTEIN
(Sindbis
virus) 		5 / 11 ASP A1343
ASP A1485
ASN A1447
SER A1297
HIS A1329
 None
 1.35A 4fewE-4guaA:
1.3
4fewF-4guaA:
0.3		 4fewE-4guaA:
19.58
4fewF-4guaA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_E_KANE301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4gua NON-STRUCTURAL
POLYPROTEIN
(Sindbis
virus) 		5 / 11 SER A1350
ASP A1343
ASN A1447
SER A1297
HIS A1329
 None
 1.38A 4fewE-4guaA:
1.3
4fewF-4guaA:
0.3		 4fewE-4guaA:
19.58
4fewF-4guaA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4gua NON-STRUCTURAL
POLYPROTEIN
(Sindbis
virus) 		5 / 11 ASP A1343
ASP A1485
ASN A1447
SER A1297
HIS A1329
 None
 1.41A 4gkhA-4guaA:
0.1
4gkhB-4guaA:
0.1		 4gkhA-4guaA:
19.58
4gkhB-4guaA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_E_KANE301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4gua NON-STRUCTURAL
POLYPROTEIN
(Sindbis
virus) 		5 / 10 ASP A1343
ASP A1485
ASN A1447
SER A1297
HIS A1329
 None
 1.39A 4gkhE-4guaA:
0.2
4gkhF-4guaA:
0.3		 4gkhE-4guaA:
19.58
4gkhF-4guaA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_H_KANH301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4gua NON-STRUCTURAL
POLYPROTEIN
(Sindbis
virus) 		5 / 10 SER A1297
HIS A1329
ASP A1343
ASP A1485
ASN A1447
 None
 1.33A 4gkhG-4guaA:
0.1
4gkhH-4guaA:
0.5		 4gkhG-4guaA:
19.58
4gkhH-4guaA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_I_KANI301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4gua NON-STRUCTURAL
POLYPROTEIN
(Sindbis
virus) 		5 / 11 ASP A1343
ASP A1485
ASN A1447
SER A1297
HIS A1329
 None
 1.34A 4gkhI-4guaA:
0.6
4gkhJ-4guaA:
0.2		 4gkhI-4guaA:
19.58
4gkhJ-4guaA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_L_KANL301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4gua NON-STRUCTURAL
POLYPROTEIN
(Sindbis
virus) 		5 / 10 SER A1297
HIS A1329
ASP A1343
ASP A1485
ASN A1447
 None
 1.33A 4gkhK-4guaA:
0.0
4gkhL-4guaA:
0.6		 4gkhK-4guaA:
19.58
4gkhL-4guaA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4gua NON-STRUCTURAL
POLYPROTEIN
(Sindbis
virus) 		5 / 11 SER A1297
HIS A1329
ASP A1343
ASP A1485
ASN A1447
 None
 1.40A 4gkiA-4guaA:
0.0
4gkiB-4guaA:
0.3		 4gkiA-4guaA:
19.58
4gkiB-4guaA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4gua NON-STRUCTURAL
POLYPROTEIN
(Sindbis
virus) 		5 / 11 SER A1297
HIS A1329
ASP A1343
ASP A1485
ASN A1447
 None
 1.33A 4gkiC-4guaA:
0.0
4gkiD-4guaA:
0.6		 4gkiC-4guaA:
19.58
4gkiD-4guaA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_H_KANH301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4gua NON-STRUCTURAL
POLYPROTEIN
(Sindbis
virus) 		5 / 10 SER A1297
HIS A1329
ASP A1343
ASP A1485
ASN A1447
 None
 1.35A 4gkiG-4guaA:
0.0
4gkiH-4guaA:
0.0		 4gkiG-4guaA:
19.58
4gkiH-4guaA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_I_KANI301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4gua NON-STRUCTURAL
POLYPROTEIN
(Sindbis
virus) 		5 / 11 ASP A1343
ASP A1485
ASN A1447
SER A1297
HIS A1329
 None
 1.39A 4gkiI-4guaA:
0.2
4gkiJ-4guaA:
0.3		 4gkiI-4guaA:
19.58
4gkiJ-4guaA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_1
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 4gua NON-STRUCTURAL
POLYPROTEIN
(Sindbis
virus) 		3 / 3 GLU A1191
TYR A1311
GLU A1309
 None
 0.59A 4ryaA-4guaA:
undetectable		 4ryaA-4guaA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB201_0
(HYDROXYNITRILE LYASE)		 4gua NON-STRUCTURAL
POLYPROTEIN
(Sindbis
virus) 		5 / 11 VAL A1634
VAL A1648
VAL A1632
ILE A1564
LEU A1640
 None
 0.95A 5e4dB-4guaA:
undetectable		 5e4dB-4guaA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_2
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 4gua NON-STRUCTURAL
POLYPROTEIN
(Sindbis
virus) 		4 / 5 LEU A1608
CYH A1610
CYH A1653
ASP A1529
 None
ZN  A1719 (-2.3A)
ZN  A1719 (-2.3A)
MES  A1718 (-3.9A)
 1.45A 5mafA-4guaA:
undetectable		 5mafA-4guaA:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMX_B_RBFB202_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 4gua NON-STRUCTURAL
POLYPROTEIN
(Sindbis
virus) 		5 / 10 LEU A1150
GLN A1244
ASN A1240
GLN A1041
GLN A1133
 None
 1.47A 5umxA-4guaA:
0.0
5umxB-4guaA:
0.0		 5umxA-4guaA:
8.61
5umxB-4guaA:
8.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11802_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
UL4
RIBOSOMAL PROTEIN
UL15
RIBOSOMAL PROTEIN
EL15)		 4gua NON-STRUCTURAL
POLYPROTEIN
(Sindbis
virus) 		3 / 3 ARG A1295
LYS A1181
ARG A1481
 None
 1.28A 6az3C-4guaA:
undetectable
6az3L-4guaA:
undetectable
6az3M-4guaA:
undetectable		 6az3C-4guaA:
9.14
6az3L-4guaA:
7.44
6az3M-4guaA:
7.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CJK_C_ACTC301_0
(IMMUNOGLOBULIN FAB
LIGHT CHAIN)		 4gua NON-STRUCTURAL
POLYPROTEIN
(Sindbis
virus) 		4 / 4 VAL A1337
GLY A1344
ASP A1343
ASP A1483
 None
 1.42A 6cjkC-4guaA:
undetectable		 6cjkC-4guaA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 4gua NON-STRUCTURAL
POLYPROTEIN
(Sindbis
virus) 		3 / 3 THR A1074
GLU A1563
ASN A1154
 SO4  A1703 (-4.3A)
None
SO4  A1703 (-3.7A)
 0.82A 6nj9K-4guaA:
5.7		 6nj9K-4guaA:
20.50