SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gud'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GM7_B_PNNB1577_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 4gud IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
SUBUNIT HISH
(Vibrio
cholerae) 		4 / 8 MET A  82
SER A 171
ALA A 173
ILE A 174
 None
 0.99A 1gm7A-4gudA:
undetectable
1gm7B-4gudA:
undetectable		 1gm7A-4gudA:
21.43
1gm7B-4gudA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_1
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 4gud IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
SUBUNIT HISH
(Vibrio
cholerae) 		3 / 3 GLY A 133
GLU A 132
ASN A 138
 None
 0.69A 1zq9A-4gudA:
undetectable		 1zq9A-4gudA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_1
(VITAMIN D RECEPTOR)		 4gud IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
SUBUNIT HISH
(Vibrio
cholerae) 		5 / 12 VAL A  18
SER A  17
VAL A 182
LEU A 136
LEU A  75
 None
 1.40A 2hc4A-4gudA:
undetectable		 2hc4A-4gudA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 4gud IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
SUBUNIT HISH
(Vibrio
cholerae) 		5 / 12 VAL A  18
SER A  17
VAL A 182
LEU A 136
LEU A  75
 None
 1.41A 2zlcA-4gudA:
undetectable		 2zlcA-4gudA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_C_ACTC4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 4gud IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
SUBUNIT HISH
(Vibrio
cholerae) 		4 / 4 GLY A  81
GLY A  48
THR A  10
LEU A  59
 None
 0.90A 3si7C-4gudA:
undetectable
3si7D-4gudA:
undetectable		 3si7C-4gudA:
21.68
3si7D-4gudA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5J_A_08HA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4gud IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
SUBUNIT HISH
(Vibrio
cholerae) 		4 / 7 PRO A  47
LEU A  84
LEU A 103
ILE A   8
 None
 0.97A 3u5jA-4gudA:
undetectable		 3u5jA-4gudA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_A_CCSA109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 4gud IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
SUBUNIT HISH
(Vibrio
cholerae) 		4 / 8 ASN A  14
ILE A   7
SER A  16
ALA A  21
 None
 0.99A 4eyzA-4gudA:
undetectable		 4eyzA-4gudA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_B_CCSB109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 4gud IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
SUBUNIT HISH
(Vibrio
cholerae) 		4 / 8 ASN A  14
ILE A   7
SER A  16
ALA A  21
 None
 1.00A 4eyzB-4gudA:
undetectable		 4eyzB-4gudA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_2
(ANDROGEN RECEPTOR)		 4gud IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
SUBUNIT HISH
(Vibrio
cholerae) 		4 / 6 ASN A  14
ILE A  31
ILE A   7
VAL A  29
 None
 0.82A 4olmA-4gudA:
undetectable		 4olmA-4gudA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_D_AQ4D602_0
(CYTOCHROME P450 1A1)		 4gud IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
SUBUNIT HISH
(Vibrio
cholerae) 		5 / 12 PHE A 184
GLY A 193
ALA A 194
ILE A  22
LEU A 201
 None
 1.05A 6dwnD-4gudA:
undetectable		 6dwnD-4gudA:
16.59