SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4guz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4guz PROBABLE ARYLAMINE
N-ACETYL TRANSFERASE
(Mycobacteroides
abscessus) 		4 / 5 LEU A 180
VAL A 114
LEU A 187
ARG A 137
 None
 1.07A 2oiqA-4guzA:
undetectable		 2oiqA-4guzA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_A_LDPA501_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 4guz PROBABLE ARYLAMINE
N-ACETYL TRANSFERASE
(Mycobacteroides
abscessus) 		4 / 7 TRP A  42
GLU A 169
PHE A 215
PHE A 210
 None
 0.78A 2qmzA-4guzA:
undetectable
2qmzB-4guzA:
undetectable		 2qmzA-4guzA:
21.74
2qmzB-4guzA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_H_DHIH3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 4guz PROBABLE ARYLAMINE
N-ACETYL TRANSFERASE
(Mycobacteroides
abscessus) 		3 / 3 LEU A 123
TRP A 165
GLY A 164
 None
 0.77A 3l35A-4guzA:
undetectable
3l35H-4guzA:
undetectable		 3l35A-4guzA:
6.74
3l35H-4guzA:
4.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_K_DHIK3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 4guz PROBABLE ARYLAMINE
N-ACETYL TRANSFERASE
(Mycobacteroides
abscessus) 		3 / 3 LEU A 123
TRP A 165
GLY A 164
 None
 0.73A 3l35B-4guzA:
undetectable
3l35K-4guzA:
undetectable		 3l35B-4guzA:
6.74
3l35K-4guzA:
4.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_C_VIBC223_1
(THIAMINE
PYROPHOSPHOKINASE)		 4guz PROBABLE ARYLAMINE
N-ACETYL TRANSFERASE
(Mycobacteroides
abscessus) 		4 / 8 ASP A 125
TYR A 151
LEU A 153
LEU A 123
 None
 0.93A 3lm8A-4guzA:
undetectable
3lm8C-4guzA:
undetectable		 3lm8A-4guzA:
19.86
3lm8C-4guzA:
19.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 4guz PROBABLE ARYLAMINE
N-ACETYL TRANSFERASE
(Mycobacteroides
abscessus) 		5 / 6 TYR A  72
CYH A  73
VAL A  98
THR A 109
PHE A 210
 None
 0.75A 3ltwA-4guzA:
33.7		 3ltwA-4guzA:
34.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_B_SAMB6735_0
(16S RRNA METHYLASE)		 4guz PROBABLE ARYLAMINE
N-ACETYL TRANSFERASE
(Mycobacteroides
abscessus) 		5 / 12 GLY A 111
GLY A 127
ALA A 108
LEU A 113
THR A 184
 None
 1.11A 3p2kB-4guzA:
undetectable		 3p2kB-4guzA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4guz PROBABLE ARYLAMINE
N-ACETYL TRANSFERASE
(Mycobacteroides
abscessus) 		4 / 8 PHE A 215
PHE A 210
TRP A  42
GLU A 169
 None
 0.84A 4fgjA-4guzA:
undetectable
4fgjB-4guzA:
undetectable		 4fgjA-4guzA:
21.28
4fgjB-4guzA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QD3_A_5AEA201_1
(PEPTIDYL-TRNA
HYDROLASE)		 4guz PROBABLE ARYLAMINE
N-ACETYL TRANSFERASE
(Mycobacteroides
abscessus) 		5 / 9 LEU A  32
GLY A  35
HIS A  36
VAL A  83
LEU A   7
 None
 1.08A 4qd3A-4guzA:
undetectable		 4qd3A-4guzA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4guz PROBABLE ARYLAMINE
N-ACETYL TRANSFERASE
(Mycobacteroides
abscessus) 		3 / 3 SER A 148
ALA A 145
VAL A 144
 None
 0.45A 4x1iA-4guzA:
undetectable		 4x1iA-4guzA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4guz PROBABLE ARYLAMINE
N-ACETYL TRANSFERASE
(Mycobacteroides
abscessus) 		4 / 7 LEU A  29
PRO A 135
LEU A 117
GLU A 120
 None
 0.83A 4z4fA-4guzA:
undetectable		 4z4fA-4guzA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_1
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 4guz PROBABLE ARYLAMINE
N-ACETYL TRANSFERASE
(Mycobacteroides
abscessus) 		5 / 12 ALA A  47
VAL A  53
VAL A  98
GLN A 217
PHE A 128
 None
 1.49A 4zj8A-4guzA:
undetectable		 4zj8A-4guzA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4guz PROBABLE ARYLAMINE
N-ACETYL TRANSFERASE
(Mycobacteroides
abscessus) 		3 / 3 SER A 148
ALA A 145
VAL A 144
 None
 0.42A 5eypA-4guzA:
undetectable		 5eypA-4guzA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 4guz PROBABLE ARYLAMINE
N-ACETYL TRANSFERASE
(Mycobacteroides
abscessus) 		4 / 8 TYR A  12
THR A  28
CYH A 124
LEU A  84
 None
 1.41A 5kxiD-4guzA:
undetectable
5kxiE-4guzA:
undetectable		 5kxiD-4guzA:
20.92
5kxiE-4guzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_B_ACTB401_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT
N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14)		 4guz PROBABLE ARYLAMINE
N-ACETYL TRANSFERASE
(Mycobacteroides
abscessus) 		4 / 6 GLU A  27
ARG A  31
ARG A  34
ARG A  30
 None
 1.22A 5l6eA-4guzA:
undetectable
5l6eB-4guzA:
undetectable		 5l6eA-4guzA:
21.99
5l6eB-4guzA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 4guz PROBABLE ARYLAMINE
N-ACETYL TRANSFERASE
(Mycobacteroides
abscessus) 		5 / 12 ASP A  46
GLU A  43
ALA A 214
ARG A  69
LEU A 252
 None
 0.98A 5m5cB-4guzA:
undetectable		 5m5cB-4guzA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4guz PROBABLE ARYLAMINE
N-ACETYL TRANSFERASE
(Mycobacteroides
abscessus) 		4 / 7 LEU A  29
PRO A 135
LEU A 117
GLU A 120
 None
 0.72A 5t7bA-4guzA:
undetectable		 5t7bA-4guzA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA CHAIN)		 4guz PROBABLE ARYLAMINE
N-ACETYL TRANSFERASE
(Mycobacteroides
abscessus) 		3 / 3 SER A 148
ALA A 145
VAL A 144
 None
 0.39A 5xiwC-4guzA:
undetectable		 5xiwC-4guzA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4guz PROBABLE ARYLAMINE
N-ACETYL TRANSFERASE
(Mycobacteroides
abscessus) 		4 / 5 GLN A 121
VAL A 115
TRP A 122
THR A  25
 None
 1.40A 6cduA-4guzA:
undetectable
6cduB-4guzA:
undetectable		 6cduA-4guzA:
22.44
6cduB-4guzA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 4guz PROBABLE ARYLAMINE
N-ACETYL TRANSFERASE
(Mycobacteroides
abscessus) 		4 / 8 TYR A  12
THR A  28
CYH A 124
LEU A  84
 None
 1.36A 6cnjD-4guzA:
undetectable
6cnjE-4guzA:
undetectable		 6cnjD-4guzA:
13.98
6cnjE-4guzA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 4guz PROBABLE ARYLAMINE
N-ACETYL TRANSFERASE
(Mycobacteroides
abscessus) 		4 / 8 TYR A  12
THR A  28
CYH A 124
LEU A  84
 None
 1.36A 6cnjD-4guzA:
undetectable
6cnjE-4guzA:
undetectable		 6cnjD-4guzA:
13.98
6cnjE-4guzA:
14.44