SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gv8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1351_1
(PROSTAGLANDIN
REDUCTASE 2)		 4gv8 DUTPASE
(Staphylococcus
virus
11) 		5 / 10 TYR A  27
ILE A 139
MET A  16
LEU A  88
VAL A  49
 None
None
None
DUP  A 201 (-4.7A)
None
 1.21A 2w98A-4gv8A:
undetectable		 2w98A-4gv8A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_A_DSFA319_1
(GLR4197 PROTEIN)		 4gv8 DUTPASE
(Staphylococcus
virus
11) 		5 / 9 TYR A 126
ILE A 110
ILE A 128
VAL A  67
ILE A  90
 None
 1.07A 3p4wA-4gv8A:
undetectable		 3p4wA-4gv8A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_B_DSFB319_1
(GLR4197 PROTEIN)		 4gv8 DUTPASE
(Staphylococcus
virus
11) 		5 / 9 TYR A 126
ILE A 110
ILE A 128
VAL A  67
ILE A  90
 None
 1.07A 3p4wB-4gv8A:
undetectable		 3p4wB-4gv8A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_D_DSFD319_1
(GLR4197 PROTEIN)		 4gv8 DUTPASE
(Staphylococcus
virus
11) 		5 / 10 TYR A 126
ILE A 110
ILE A 128
VAL A  67
ILE A  90
 None
 1.07A 3p4wD-4gv8A:
undetectable		 3p4wD-4gv8A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_E_DSFE319_1
(GLR4197 PROTEIN)		 4gv8 DUTPASE
(Staphylococcus
virus
11) 		5 / 10 TYR A 126
ILE A 110
ILE A 128
VAL A  67
ILE A  90
 None
 1.08A 3p4wE-4gv8A:
undetectable		 3p4wE-4gv8A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L78_A_ACTA1327_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 4gv8 DUTPASE
(Staphylococcus
virus
11) 		4 / 4 VAL A  35
THR A  34
GLU A  33
GLU A 130
 None
 1.28A 4l78A-4gv8A:
undetectable		 4l78A-4gv8A:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVN_B_PFLB410_1
(PROTON-GATED ION
CHANNEL)		 4gv8 DUTPASE
(Staphylococcus
virus
11) 		5 / 9 TYR A 126
ILE A 110
ILE A 128
VAL A  67
ILE A  90
 None
 1.15A 5mvnB-4gv8A:
undetectable		 5mvnB-4gv8A:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_A_PFLA412_1
(PROTON-GATED ION
CHANNEL)		 4gv8 DUTPASE
(Staphylococcus
virus
11) 		5 / 10 TYR A 126
ILE A 110
ILE A 128
VAL A  67
ILE A  90
 None
 1.11A 5mzrA-4gv8A:
undetectable		 5mzrA-4gv8A:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_C_PFLC409_1
(PROTON-GATED ION
CHANNEL)		 4gv8 DUTPASE
(Staphylococcus
virus
11) 		5 / 10 TYR A 126
ILE A 110
ILE A 128
VAL A  67
ILE A  90
 None
 1.13A 5mzrC-4gv8A:
undetectable		 5mzrC-4gv8A:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)		 4gv8 DUTPASE
(Staphylococcus
virus
11) 		5 / 9 TYR A 126
ILE A 110
ILE A 128
VAL A  67
ILE A  90
 None
 1.11A 5mzrD-4gv8A:
undetectable		 5mzrD-4gv8A:
24.60