SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gve'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KT7_A_RTLA184_0 (PLASMA RETINOL-BINDING PROTEIN)	4gve	NUCLEOPROTEIN (Tacaribe mammarenavirus)	5 / 11	LEU A 556 LEU A 443 VAL A 446 LEU A 399 HIS A 428	None	1.01A	1kt7A-4gveA: undetectable	1kt7A-4gveA: 18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1TDR_B_MTXB170_1 (TELLUROMETHIONYL DIHYDROFOLATE REDUCTASE)	4gve	NUCLEOPROTEIN (Tacaribe mammarenavirus)	5 / 10	ALA A 532 LEU A 399 ILE A 447 ARG A 473 LEU A 468	None	1.38A	1tdrB-4gveA: undetectable	1tdrB-4gveA: 22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A79_B_P1BB601_1 (AMINE OXIDASE [FLAVIN-CONTAINING] B)	4gve	NUCLEOPROTEIN (Tacaribe mammarenavirus)	5 / 12	PRO A 394 LEU A 443 LEU A 468 ILE A 470 ILE A 387	None	1.23A	4a79B-4gveA: undetectable	4a79B-4gveA: 19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QI9_B_MTXB201_1 (DIHYDROFOLATE REDUCTASE)	4gve	NUCLEOPROTEIN (Tacaribe mammarenavirus)	6 / 12	ALA A 532 LEU A 399 SER A 444 ILE A 447 ARG A 473 LEU A 468	None	1.44A	4qi9B-4gveA: undetectable	4qi9B-4gveA: 22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5C0O_H_SAMH301_1 (TRNA (ADENINE(58)-N(1))-M ETHYLTRANSFERASE TRMI)	4gve	NUCLEOPROTEIN (Tacaribe mammarenavirus)	4 / 5	GLY A 460 GLU A 388 HIS A 530 ASP A 463	None MG A 602 (-2.5A) None None	1.24A	5c0oH-4gveA: undetectable	5c0oH-4gveA: 20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EB3_A_UEGA202_1 (YFIR)	4gve	NUCLEOPROTEIN (Tacaribe mammarenavirus)	4 / 4	LEU A 399 ILE A 383 PRO A 451 LEU A 476	None	1.17A	5eb3A-4gveA: undetectable	5eb3A-4gveA: 21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Y7P_E_CHDE401_0 (BILE SALT HYDROLASE)	4gve	NUCLEOPROTEIN (Tacaribe mammarenavirus)	4 / 8	ILE A 456 LEU A 399 LEU A 533 ALA A 532	None	0.78A	5y7pE-4gveA: undetectable	5y7pE-4gveA: 20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Y7P_G_CHDG401_0 (BILE SALT HYDROLASE)	4gve	NUCLEOPROTEIN (Tacaribe mammarenavirus)	5 / 10	LEU A 467 ILE A 456 LEU A 399 LEU A 533 ALA A 532	None	1.26A	5y7pG-4gveA: undetectable	5y7pG-4gveA: 20.80

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1KT7_A_RTLA184_0","PLASMA RETINOL-BINDING PROTEIN","4gve","NUCLEOPROTEIN","Tacaribe mammarenavirus",5,"LEU A 556;LEU A 443;VAL A 446;LEU A 399;HIS A 428","None","1.01A","1kt7A-4gveA:undetectable","1kt7A-4gveA:18.57"],["1TDR_B_MTXB170_1","TELLUROMETHIONYL DIHYDROFOLATE REDUCTASE","4gve","NUCLEOPROTEIN","Tacaribe mammarenavirus",5,"ALA A 532;LEU A 399;ILE A 447;ARG A 473;LEU A 468","None","1.38A","1tdrB-4gveA:undetectable","1tdrB-4gveA:22.77"],["4A79_B_P1BB601_1","AMINE OXIDASE [FLAVIN-CONTAINING] B","4gve","NUCLEOPROTEIN","Tacaribe mammarenavirus",5,"PRO A 394;LEU A 443;LEU A 468;ILE A 470;ILE A 387","None","1.23A","4a79B-4gveA:undetectable","4a79B-4gveA:19.16"],["4QI9_B_MTXB201_1","DIHYDROFOLATE REDUCTASE","4gve","NUCLEOPROTEIN","Tacaribe mammarenavirus",6,"ALA A 532;LEU A 399;SER A 444;ILE A 447;ARG A 473;LEU A 468","None","1.44A","4qi9B-4gveA:undetectable","4qi9B-4gveA:22.54"],["5C0O_H_SAMH301_1","TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE TRMI","4gve","NUCLEOPROTEIN","Tacaribe mammarenavirus",4,"GLY A 460;GLU A 388;HIS A 530;ASP A 463","None; MG A 602 (-2.5A);None;None","1.24A","5c0oH-4gveA:undetectable","5c0oH-4gveA:20.61"],["5EB3_A_UEGA202_1","YFIR","4gve","NUCLEOPROTEIN","Tacaribe mammarenavirus",4,"LEU A 399;ILE A 383;PRO A 451;LEU A 476","None","1.17A","5eb3A-4gveA:undetectable","5eb3A-4gveA:21.26"],["5Y7P_E_CHDE401_0","BILE SALT HYDROLASE","4gve","NUCLEOPROTEIN","Tacaribe mammarenavirus",4,"ILE A 456;LEU A 399;LEU A 533;ALA A 532","None","0.78A","5y7pE-4gveA:undetectable","5y7pE-4gveA:20.80"],["5Y7P_G_CHDG401_0","BILE SALT HYDROLASE","4gve","NUCLEOPROTEIN","Tacaribe mammarenavirus",5,"LEU A 467;ILE A 456;LEU A 399;LEU A 533;ALA A 532","None","1.26A","5y7pG-4gveA:undetectable","5y7pG-4gveA:20.80"]]