SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gvf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_1
(DIHYDROFOLATE
REDUCTASE)		 4gvf BETA-HEXOSAMINIDASE
(Salmonella
enterica) 		5 / 12 ALA A  97
LEU A 121
VAL A 196
LEU A 200
ILE A 150
 None
 0.95A 1df7A-4gvfA:
undetectable		 1df7A-4gvfA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 4gvf BETA-HEXOSAMINIDASE
(Salmonella
enterica) 		5 / 12 ALA A 265
GLY A 272
LEU A  25
ALA A 297
LEU A 292
 None
 1.22A 1jipA-4gvfA:
undetectable		 1jipA-4gvfA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB503_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4gvf BETA-HEXOSAMINIDASE
(Salmonella
enterica) 		4 / 6 ALA A 224
TYR A 229
ILE A 189
PRO A 166
 None
 0.99A 1oniB-4gvfA:
undetectable
1oniC-4gvfA:
undetectable		 1oniB-4gvfA:
15.34
1oniC-4gvfA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_H_BEZH515_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4gvf BETA-HEXOSAMINIDASE
(Salmonella
enterica) 		4 / 6 ALA A 224
TYR A 229
ILE A 189
PRO A 166
 None
 1.05A 1oniH-4gvfA:
undetectable
1oniI-4gvfA:
undetectable		 1oniH-4gvfA:
15.34
1oniI-4gvfA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_H_BEZH515_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4gvf BETA-HEXOSAMINIDASE
(Salmonella
enterica) 		4 / 6 PHE A 165
ALA A 224
TYR A 229
ILE A 189
 None
 1.22A 1oniH-4gvfA:
undetectable
1oniI-4gvfA:
undetectable		 1oniH-4gvfA:
15.34
1oniI-4gvfA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI517_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4gvf BETA-HEXOSAMINIDASE
(Salmonella
enterica) 		4 / 7 TYR A 229
ILE A 189
PRO A 166
ALA A 224
 None
 1.00A 1oniG-4gvfA:
undetectable
1oniI-4gvfA:
undetectable		 1oniG-4gvfA:
15.34
1oniI-4gvfA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_C_STRC3001_1
(MINERALOCORTICOID
RECEPTOR)		 4gvf BETA-HEXOSAMINIDASE
(Salmonella
enterica) 		5 / 12 LEU A  31
ALA A  60
ARG A  50
LEU A   6
CYH A 279
 None
 0.95A 1ya3C-4gvfA:
undetectable		 1ya3C-4gvfA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_B_CQAB401_0
(HISTAMINE
N-METHYLTRANSFERASE)		 4gvf BETA-HEXOSAMINIDASE
(Salmonella
enterica) 		4 / 7 TRP A 230
PRO A 180
ASP A 182
TYR A 216
 None
 1.14A 2aouB-4gvfA:
undetectable		 2aouB-4gvfA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		 4gvf BETA-HEXOSAMINIDASE
(Salmonella
enterica) 		4 / 6 ILE A  49
ARG A  18
LEU A  21
LEU A  45
 None
 0.95A 2rlfA-4gvfA:
undetectable
2rlfD-4gvfA:
undetectable		 2rlfA-4gvfA:
8.72
2rlfD-4gvfA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4gvf BETA-HEXOSAMINIDASE
(Salmonella
enterica) 		5 / 12 LEU A 269
GLY A 272
VAL A 288
PRO A   3
GLY A   2
 None
 1.29A 2vmyB-4gvfA:
undetectable		 2vmyB-4gvfA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		 4gvf BETA-HEXOSAMINIDASE
(Salmonella
enterica) 		4 / 5 VAL A 288
TYR A 261
ASP A 249
SER A 247
 None
 1.06A 2x45A-4gvfA:
undetectable		 2x45A-4gvfA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOB_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4gvf BETA-HEXOSAMINIDASE
(Salmonella
enterica) 		5 / 12 GLN A  69
PHE A 117
ALA A 118
ARG A  67
GLY A  65
 None
NDG  A 401 ( 4.7A)
None
None
None
 1.20A 3aobC-4gvfA:
undetectable		 3aobC-4gvfA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D9L_A_ACTA501_0
(CTD-PEPTIDE
RNA-BINDING PROTEIN
16)		 4gvf BETA-HEXOSAMINIDASE
(Salmonella
enterica) 		4 / 5 PRO A 221
ILE A 215
PRO A 223
TYR A 216
 None
 1.14A 3d9lA-4gvfA:
0.8
3d9lY-4gvfA:
undetectable		 3d9lA-4gvfA:
16.10
3d9lY-4gvfA:
4.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DLC_A_SAMA220_0
(PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE)		 4gvf BETA-HEXOSAMINIDASE
(Salmonella
enterica) 		5 / 12 GLY A 124
GLY A 169
ASP A 138
ARG A 133
SER A 134
 None
None
None
NDG  A 401 ( 2.8A)
None
 1.08A 3dlcA-4gvfA:
undetectable		 3dlcA-4gvfA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 4gvf BETA-HEXOSAMINIDASE
(Salmonella
enterica) 		5 / 12 GLY A  93
GLY A  89
ASP A 151
PRO A 119
LEU A 121
 None
 1.00A 3m6vA-4gvfA:
undetectable		 3m6vA-4gvfA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 4gvf BETA-HEXOSAMINIDASE
(Salmonella
enterica) 		5 / 12 GLY A  93
GLY A  89
ASP A 151
PRO A 119
LEU A 121
 None
 1.05A 3m6vB-4gvfA:
2.2		 3m6vB-4gvfA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6W_A_SAMA465_0
(RRNA METHYLASE)		 4gvf BETA-HEXOSAMINIDASE
(Salmonella
enterica) 		5 / 12 GLY A  93
GLY A  89
ASP A 151
PRO A 119
LEU A 121
 None
 0.99A 3m6wA-4gvfA:
undetectable		 3m6wA-4gvfA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_DIFB585_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4gvf BETA-HEXOSAMINIDASE
(Salmonella
enterica) 		5 / 12 VAL A   4
VAL A 278
LEU A 250
SER A 251
LEU A 289
 None
 1.08A 3n8yB-4gvfA:
undetectable		 3n8yB-4gvfA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4gvf BETA-HEXOSAMINIDASE
(Salmonella
enterica) 		4 / 5 GLY A  28
GLY A  27
MET A   1
ASN A  55
 None
 1.23A 4fglC-4gvfA:
undetectable		 4fglC-4gvfA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_1
(ANCESTRAL STEROID
RECEPTOR 2)		 4gvf BETA-HEXOSAMINIDASE
(Salmonella
enterica) 		5 / 12 LEU A  31
ALA A  60
ARG A  50
LEU A   6
CYH A 279
 None
 1.05A 4ltwA-4gvfA:
undetectable		 4ltwA-4gvfA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_A_5OGA804_1
(HDAC6 PROTEIN)		 4gvf BETA-HEXOSAMINIDASE
(Salmonella
enterica) 		5 / 12 PRO A 180
SER A 225
ASP A 122
HIS A 164
GLY A 169
 None
None
None
NDG  A 401 ( 3.6A)
None
 1.28A 5eenA-4gvfA:
undetectable		 5eenA-4gvfA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_C_REAC602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 4gvf BETA-HEXOSAMINIDASE
(Salmonella
enterica) 		5 / 10 ILE A 113
LEU A  29
PHE A  71
LEU A  45
LEU A  13
 None
 1.19A 5fhzC-4gvfA:
undetectable		 5fhzC-4gvfA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 4gvf BETA-HEXOSAMINIDASE
(Salmonella
enterica) 		4 / 8 THR A 179
SER A 127
ALA A 212
ASP A 122
 None
 1.13A 5l5fY-4gvfA:
undetectable
5l5fZ-4gvfA:
undetectable		 5l5fY-4gvfA:
21.51
5l5fZ-4gvfA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M6G_A_SORA711_0
(BETA-GLUCOSIDASE)		 4gvf BETA-HEXOSAMINIDASE
(Salmonella
enterica) 		5 / 12 ASP A  62
PHE A 117
LYS A 163
HIS A 164
MET A 210
 NDG  A 401 ( 3.0A)
NDG  A 401 ( 4.7A)
NDG  A 401 ( 2.9A)
NDG  A 401 ( 3.6A)
NDG  A 401 ( 4.3A)
 0.71A 5m6gA-4gvfA:
25.3		 5m6gA-4gvfA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA405_0
(THIOREDOXIN
REDUCTASE)		 4gvf BETA-HEXOSAMINIDASE
(Salmonella
enterica) 		3 / 3 GLY A  93
LEU A  96
HIS A  88
 None
 0.70A 5u63A-4gvfA:
undetectable		 5u63A-4gvfA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_B_ACTB405_0
(THIOREDOXIN
REDUCTASE)		 4gvf BETA-HEXOSAMINIDASE
(Salmonella
enterica) 		3 / 3 GLY A  93
LEU A  96
HIS A  88
 None
 0.65A 5u63B-4gvfA:
undetectable		 5u63B-4gvfA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Q_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4gvf BETA-HEXOSAMINIDASE
(Salmonella
enterica) 		4 / 6 SER A 225
HIS A 213
ARG A 264
GLU A 253
 None
 1.37A 5x7qB-4gvfA:
1.2		 5x7qB-4gvfA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7R_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4gvf BETA-HEXOSAMINIDASE
(Salmonella
enterica) 		4 / 6 SER A 225
HIS A 213
ARG A 264
GLU A 253
 None
 1.34A 5x7rB-4gvfA:
1.2		 5x7rB-4gvfA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_C_9CRC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4gvf BETA-HEXOSAMINIDASE
(Salmonella
enterica) 		5 / 12 ILE A  49
ALA A  52
ALA A  51
LEU A  21
ALA A  22
 None
 1.01A 5z12C-4gvfA:
undetectable		 5z12C-4gvfA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4gvf BETA-HEXOSAMINIDASE
(Salmonella
enterica) 		4 / 8 ASP A 112
ILE A 113
ARG A  43
ARG A  50
 None
 1.03A 6hisA-4gvfA:
undetectable
6hisB-4gvfA:
undetectable		 6hisA-4gvfA:
11.36
6hisB-4gvfA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4gvf BETA-HEXOSAMINIDASE
(Salmonella
enterica) 		4 / 8 ASP A 112
ILE A 113
ARG A  43
ARG A  50
 None
 1.04A 6hisB-4gvfA:
undetectable
6hisC-4gvfA:
undetectable		 6hisB-4gvfA:
11.36
6hisC-4gvfA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4gvf BETA-HEXOSAMINIDASE
(Salmonella
enterica) 		4 / 8 ASP A 112
ILE A 113
ARG A  43
ARG A  50
 None
 1.03A 6hisC-4gvfA:
undetectable
6hisD-4gvfA:
undetectable		 6hisC-4gvfA:
11.36
6hisD-4gvfA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4gvf BETA-HEXOSAMINIDASE
(Salmonella
enterica) 		4 / 8 ASP A 112
ILE A 113
ARG A  43
ARG A  50
 None
 1.03A 6hisD-4gvfA:
undetectable
6hisE-4gvfA:
undetectable		 6hisD-4gvfA:
11.36
6hisE-4gvfA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4gvf BETA-HEXOSAMINIDASE
(Salmonella
enterica) 		4 / 8 ASP A 112
ILE A 113
ARG A  43
ARG A  50
 None
 1.03A 6hisA-4gvfA:
undetectable
6hisE-4gvfA:
undetectable		 6hisA-4gvfA:
11.36
6hisE-4gvfA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4gvf BETA-HEXOSAMINIDASE
(Salmonella
enterica) 		3 / 3 ARG A 333
LEU A  87
PHE A  85
 None
 0.75A 6nknP-4gvfA:
undetectable		 6nknP-4gvfA:
21.60