SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gvl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVT_A_FLPA125_1
(TRANSTHYRETIN)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		4 / 8 LEU A 280
ALA A 278
LEU A 329
LEU A 530
 None
 0.91A 1dvtA-4gvlA:
undetectable
1dvtB-4gvlA:
undetectable		 1dvtA-4gvlA:
15.12
1dvtB-4gvlA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 ALA A 365
GLY A 358
ALA A 366
THR A 418
ILE A 356
 None
AMP  A 602 (-3.6A)
None
None
None
 1.14A 1gtnB-4gvlA:
undetectable
1gtnC-4gvlA:
undetectable		 1gtnB-4gvlA:
10.47
1gtnC-4gvlA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 ALA A 365
HIS A 359
ALA A 366
THR A 418
ILE A 416
 None
ZN  A 601 (-3.4A)
None
None
None
 1.05A 1gtnB-4gvlA:
undetectable
1gtnC-4gvlA:
undetectable		 1gtnB-4gvlA:
10.47
1gtnC-4gvlA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 ALA A 365
GLY A 358
ALA A 366
THR A 418
ILE A 356
 None
AMP  A 602 (-3.6A)
None
None
None
 1.17A 1gtnH-4gvlA:
undetectable
1gtnI-4gvlA:
undetectable		 1gtnH-4gvlA:
10.47
1gtnI-4gvlA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 ALA A 365
HIS A 359
ALA A 366
THR A 418
ILE A 416
 None
ZN  A 601 (-3.4A)
None
None
None
 1.11A 1gtnH-4gvlA:
undetectable
1gtnI-4gvlA:
undetectable		 1gtnH-4gvlA:
10.47
1gtnI-4gvlA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_M_TRPM81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 11 GLY A 358
ALA A 366
THR A 418
ILE A 356
ALA A 365
 AMP  A 602 (-3.6A)
None
None
None
None
 1.13A 1gtnM-4gvlA:
undetectable
1gtnN-4gvlA:
undetectable		 1gtnM-4gvlA:
10.47
1gtnN-4gvlA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_M_TRPM81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 11 HIS A 359
ALA A 366
THR A 418
ILE A 416
ALA A 365
 ZN  A 601 (-3.4A)
None
None
None
None
 1.13A 1gtnM-4gvlA:
undetectable
1gtnN-4gvlA:
undetectable		 1gtnM-4gvlA:
10.47
1gtnN-4gvlA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_O_TRPO81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 GLY A 358
HIS A 359
ALA A 366
THR A 418
ALA A 365
 AMP  A 602 (-3.6A)
ZN  A 601 (-3.4A)
None
None
None
 1.39A 1gtnO-4gvlA:
undetectable
1gtnP-4gvlA:
undetectable		 1gtnO-4gvlA:
10.47
1gtnP-4gvlA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 9 GLY A 358
HIS A 359
ALA A 366
THR A 418
ALA A 365
 AMP  A 602 (-3.6A)
ZN  A 601 (-3.4A)
None
None
None
 1.33A 1gtnQ-4gvlA:
undetectable
1gtnR-4gvlA:
undetectable		 1gtnQ-4gvlA:
10.47
1gtnR-4gvlA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6I_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		4 / 7 PHE A 175
GLU A 171
ARG A 143
VAL A 177
 None
 1.44A 1p6iA-4gvlA:
undetectable
1p6iB-4gvlA:
undetectable		 1p6iA-4gvlA:
21.52
1p6iB-4gvlA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_B_PODB700_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 12 VAL A 231
CYH A 212
LEU A 213
ALA A 239
ALA A 225
 None
 1.04A 1sa1A-4gvlA:
5.2
1sa1B-4gvlA:
4.7		 1sa1A-4gvlA:
21.51
1sa1B-4gvlA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_D_PODD701_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 12 VAL A 231
CYH A 212
LEU A 213
ALA A 239
ALA A 225
 None
 1.01A 1sa1C-4gvlA:
4.7
1sa1D-4gvlA:
4.8		 1sa1C-4gvlA:
21.51
1sa1D-4gvlA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_2
(DIHYDROFOLATE
REDUCTASE)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		4 / 4 SER A 304
ILE A 306
VAL A 519
THR A 537
 None
 0.97A 1u70A-4gvlA:
2.5		 1u70A-4gvlA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_T_TRPT81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 GLY A 358
ALA A 366
THR A 418
ILE A 356
ALA A 365
 AMP  A 602 (-3.6A)
None
None
None
None
 1.15A 1utdT-4gvlA:
undetectable
1utdU-4gvlA:
undetectable		 1utdT-4gvlA:
10.47
1utdU-4gvlA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC2_0
(N8-ACTINOMYCIN D)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		3 / 3 THR A 142
PRO A 140
THR A 144
 None
 0.80A 209dC-4gvlA:
undetectable		 209dC-4gvlA:
4.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A7Q_A_CFBA328_2
(DEOXYCYTIDINE KINASE)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		4 / 4 ILE A 546
ASP A 558
LEU A 510
ARG A 544
 None
 1.37A 2a7qA-4gvlA:
undetectable		 2a7qA-4gvlA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		4 / 5 GLY A 502
PRO A 524
ALA A 523
ILE A 521
 None
 0.92A 2aofA-4gvlA:
undetectable		 2aofA-4gvlA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 12 LEU A 323
ILE A 292
ILE A 297
LEU A 331
LEU A 280
 None
 1.00A 2bdmA-4gvlA:
undetectable		 2bdmA-4gvlA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G6H_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		4 / 8 ARG A 143
VAL A 177
PHE A 175
GLU A 171
 None
 1.44A 2g6hA-4gvlA:
undetectable
2g6hB-4gvlA:
undetectable		 2g6hA-4gvlA:
21.44
2g6hB-4gvlA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACTB601_0
(ACETYLCHOLINESTERASE)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		4 / 7 GLY A 363
ALA A 367
ALA A 366
HIS A 391
 None
None
None
ZN  A 601 (-2.9A)
 0.66A 2ha4B-4gvlA:
undetectable		 2ha4B-4gvlA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I2Z_A_SALA1100_1
(SERUM ALBUMIN)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		4 / 5 LEU A 496
LEU A 510
ILE A 518
ILE A 505
 None
 0.70A 2i2zA-4gvlA:
undetectable		 2i2zA-4gvlA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		4 / 6 ASP A 381
ASP A 421
THR A 424
ASP A 397
 AMP  A 602 (-3.1A)
None
AMP  A 602 ( 4.4A)
AMP  A 602 (-3.1A)
 1.17A 2j2pE-4gvlA:
undetectable
2j2pF-4gvlA:
undetectable		 2j2pE-4gvlA:
20.55
2j2pF-4gvlA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_2
(ESTROGEN RECEPTOR)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		4 / 4 LEU A 275
THR A 334
ILE A 268
HIS A 267
 None
 1.23A 2jfaB-4gvlA:
undetectable		 2jfaB-4gvlA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		4 / 7 TYR A 119
VAL A 178
TYR A 163
ILE A 123
 None
 1.13A 2xz5B-4gvlA:
undetectable
2xz5E-4gvlA:
undetectable		 2xz5B-4gvlA:
16.59
2xz5E-4gvlA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		4 / 8 ILE A 123
TYR A 119
VAL A 178
TYR A 163
 None
 1.14A 2xz5A-4gvlA:
undetectable
2xz5C-4gvlA:
undetectable		 2xz5A-4gvlA:
16.59
2xz5C-4gvlA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		4 / 8 ILE A 123
TYR A 119
VAL A 178
TYR A 163
 None
 1.13A 2xz5C-4gvlA:
undetectable
2xz5D-4gvlA:
undetectable		 2xz5C-4gvlA:
16.59
2xz5D-4gvlA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		4 / 7 ILE A 123
TYR A 119
VAL A 178
TYR A 163
 None
 1.13A 2xz5D-4gvlA:
undetectable
2xz5E-4gvlA:
undetectable		 2xz5D-4gvlA:
16.59
2xz5E-4gvlA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B3M_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		4 / 7 ARG A 143
VAL A 177
PHE A 175
GLU A 171
 None
 1.42A 3b3mA-4gvlA:
undetectable
3b3mB-4gvlA:
undetectable		 3b3mA-4gvlA:
21.36
3b3mB-4gvlA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 12 VAL A 193
ALA A 196
VAL A 178
THR A 214
ILE A 223
 None
None
None
CA  A 604 (-3.2A)
None
 1.10A 3czhA-4gvlA:
undetectable		 3czhA-4gvlA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DXY_A_SAMA1_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 11 GLY A 358
GLY A 360
ILE A 380
ASP A 397
ALA A 398
 AMP  A 602 (-3.6A)
AMP  A 602 (-3.4A)
None
AMP  A 602 (-3.1A)
AMP  A 602 (-3.7A)
 0.96A 3dxyA-4gvlA:
6.5		 3dxyA-4gvlA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKX_B_1UNB201_2
(PROTEASE)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 11 ALA A 365
ILE A 356
GLY A 256
ILE A 257
ILE A 362
 None
None
None
None
AMP  A 602 (-4.3A)
 0.99A 3ekxB-4gvlA:
undetectable		 3ekxB-4gvlA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HSN_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		4 / 7 ARG A 143
VAL A 177
PHE A 175
GLU A 171
 None
 1.45A 3hsnA-4gvlA:
undetectable
3hsnB-4gvlA:
undetectable		 3hsnA-4gvlA:
21.36
3hsnB-4gvlA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HSO_B_H4BB1760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		4 / 7 PHE A 175
GLU A 171
ARG A 143
VAL A 177
 None
 1.43A 3hsoA-4gvlA:
undetectable
3hsoB-4gvlA:
undetectable		 3hsoA-4gvlA:
21.36
3hsoB-4gvlA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_B_URFB400_1
(URIDINE
PHOSPHORYLASE 1)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		4 / 8 GLY A 474
LEU A 476
LEU A 477
ILE A 224
 None
 0.84A 3nbqB-4gvlA:
undetectable		 3nbqB-4gvlA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_C_URFC400_1
(URIDINE
PHOSPHORYLASE 1)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		4 / 8 GLY A 474
LEU A 476
LEU A 477
ILE A 224
 None
 0.84A 3nbqC-4gvlA:
1.5		 3nbqC-4gvlA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDW_A_RITA100_2
(PROTEASE)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 9 ALA A 365
ILE A 356
GLY A 256
ILE A 257
ILE A 362
 None
None
None
None
AMP  A 602 (-4.3A)
 0.99A 3ndwB-4gvlA:
undetectable		 3ndwB-4gvlA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNZ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		4 / 7 ARG A 143
VAL A 177
PHE A 175
GLU A 171
 None
 1.43A 3nnzA-4gvlA:
undetectable
3nnzB-4gvlA:
undetectable		 3nnzA-4gvlA:
21.36
3nnzB-4gvlA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_1
(PROTEASE)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 9 ALA A 365
ILE A 356
GLY A 256
ILE A 257
ILE A 362
 None
None
None
None
AMP  A 602 (-4.3A)
 1.12A 3nuoA-4gvlA:
undetectable		 3nuoA-4gvlA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1C_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 PHE A 377
ILE A 416
LEU A 379
HIS A 391
HIS A 359
 None
None
None
ZN  A 601 (-2.9A)
ZN  A 601 (-3.4A)
 1.19A 3o1cA-4gvlA:
undetectable		 3o1cA-4gvlA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1X_A_ADNA1450_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 PHE A 377
ILE A 416
LEU A 379
HIS A 391
HIS A 359
 None
None
None
ZN  A 601 (-2.9A)
ZN  A 601 (-3.4A)
 1.18A 3o1xA-4gvlA:
undetectable		 3o1xA-4gvlA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGZ_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 PHE A 377
ILE A 416
LEU A 379
HIS A 391
HIS A 359
 None
None
None
ZN  A 601 (-2.9A)
ZN  A 601 (-3.4A)
 1.20A 3qgzA-4gvlA:
undetectable		 3qgzA-4gvlA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		4 / 7 ILE A 268
GLU A 279
TYR A 254
VAL A 442
 None
 1.06A 4a97H-4gvlA:
undetectable		 4a97H-4gvlA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_A_QMRA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 TYR A 119
VAL A 178
TYR A 163
VAL A 187
ILE A 123
 None
 1.42A 4aftA-4gvlA:
0.0
4aftB-4gvlA:
0.0		 4aftA-4gvlA:
16.59
4aftB-4gvlA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_B_QMRB301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 9 TYR A 119
VAL A 178
TYR A 163
VAL A 187
ILE A 123
 None
 1.44A 4aftB-4gvlA:
0.0
4aftC-4gvlA:
0.0		 4aftB-4gvlA:
16.59
4aftC-4gvlA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_C_QMRC301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 9 TYR A 119
VAL A 178
TYR A 163
VAL A 187
ILE A 123
 None
 1.44A 4aftC-4gvlA:
0.0
4aftD-4gvlA:
0.0		 4aftC-4gvlA:
16.59
4aftD-4gvlA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_D_QMRD301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 8 TYR A 119
VAL A 178
TYR A 163
VAL A 187
ILE A 123
 None
 1.48A 4aftD-4gvlA:
undetectable
4aftE-4gvlA:
undetectable		 4aftD-4gvlA:
16.59
4aftE-4gvlA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_E_QMRE301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 VAL A 187
ILE A 123
TYR A 119
VAL A 178
TYR A 163
 None
 1.34A 4aftA-4gvlA:
0.0
4aftE-4gvlA:
0.0		 4aftA-4gvlA:
16.59
4aftE-4gvlA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQT_C_C5EC301_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		4 / 8 TYR A 119
VAL A 178
TYR A 163
ILE A 123
 None
 1.26A 4bqtC-4gvlA:
undetectable
4bqtD-4gvlA:
undetectable		 4bqtC-4gvlA:
16.59
4bqtD-4gvlA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_A_ADNA401_1
(APH(2'')-ID)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 ALA A 506
PRO A 533
ILE A 521
LEU A 545
ILE A 518
 None
 1.19A 4dtaA-4gvlA:
undetectable		 4dtaA-4gvlA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_A_ACTA304_0
(GLUTATHIONE
TRANSFERASE GTE1)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		4 / 5 ALA A 445
ILE A 362
LEU A 251
ASN A 446
 None
AMP  A 602 (-4.3A)
None
None
 1.18A 4g19A-4gvlA:
undetectable		 4g19A-4gvlA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCH_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		4 / 7 ARG A 143
VAL A 177
PHE A 175
GLU A 171
 None
 1.46A 4uchA-4gvlA:
undetectable
4uchB-4gvlA:
undetectable		 4uchA-4gvlA:
21.03
4uchB-4gvlA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 12 GLY A 358
ASP A 381
PHE A 377
ILE A 356
ALA A 366
 AMP  A 602 (-3.6A)
AMP  A 602 (-3.1A)
None
None
None
 1.03A 4wh5A-4gvlA:
undetectable		 4wh5A-4gvlA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AIN_A_QMRA1207_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 TYR A 119
VAL A 178
TYR A 163
VAL A 187
ILE A 123
 None
 1.45A 5ainA-4gvlA:
0.0
5ainB-4gvlA:
0.0		 5ainA-4gvlA:
17.35
5ainB-4gvlA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AIN_B_QMRB1207_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 TYR A 119
VAL A 178
TYR A 163
VAL A 187
ILE A 123
 None
 1.44A 5ainB-4gvlA:
0.0
5ainC-4gvlA:
0.0		 5ainB-4gvlA:
17.35
5ainC-4gvlA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AIN_E_QMRE1207_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 VAL A 187
ILE A 123
TYR A 119
VAL A 178
TYR A 163
 None
 1.48A 5ainA-4gvlA:
0.0
5ainE-4gvlA:
0.0		 5ainA-4gvlA:
17.35
5ainE-4gvlA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 ALA A 365
GLY A 358
ALA A 366
THR A 418
ILE A 356
 None
AMP  A 602 (-3.6A)
None
None
None
 1.12A 5eeuF-4gvlA:
undetectable
5eeuG-4gvlA:
undetectable		 5eeuF-4gvlA:
10.47
5eeuG-4gvlA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 ALA A 365
HIS A 359
ALA A 366
THR A 418
ILE A 416
 None
ZN  A 601 (-3.4A)
None
None
None
 1.07A 5eeuF-4gvlA:
undetectable
5eeuG-4gvlA:
undetectable		 5eeuF-4gvlA:
10.47
5eeuG-4gvlA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 12 ALA A 365
GLY A 358
ALA A 366
THR A 418
ILE A 356
 None
AMP  A 602 (-3.6A)
None
None
None
 1.11A 5eeuI-4gvlA:
undetectable
5eeuJ-4gvlA:
undetectable		 5eeuI-4gvlA:
10.47
5eeuJ-4gvlA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 12 ALA A 365
HIS A 359
ALA A 366
THR A 418
ILE A 416
 None
ZN  A 601 (-3.4A)
None
None
None
 1.06A 5eeuI-4gvlA:
undetectable
5eeuJ-4gvlA:
undetectable		 5eeuI-4gvlA:
10.47
5eeuJ-4gvlA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 GLY A 358
ALA A 366
THR A 418
ILE A 356
ALA A 365
 AMP  A 602 (-3.6A)
None
None
None
None
 1.13A 5eeuO-4gvlA:
undetectable
5eeuP-4gvlA:
undetectable		 5eeuO-4gvlA:
10.47
5eeuP-4gvlA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 GLY A 358
ALA A 366
THR A 418
ILE A 356
ALA A 365
 AMP  A 602 (-3.6A)
None
None
None
None
 1.14A 5eeuQ-4gvlA:
undetectable
5eeuR-4gvlA:
undetectable		 5eeuQ-4gvlA:
10.47
5eeuR-4gvlA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 HIS A 359
ALA A 366
THR A 418
ILE A 416
ALA A 365
 ZN  A 601 (-3.4A)
None
None
None
None
 1.07A 5eeuQ-4gvlA:
undetectable
5eeuR-4gvlA:
undetectable		 5eeuQ-4gvlA:
10.47
5eeuR-4gvlA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 ALA A 365
GLY A 358
ALA A 366
THR A 418
ILE A 356
 None
AMP  A 602 (-3.6A)
None
None
None
 1.12A 5eevF-4gvlA:
undetectable
5eevG-4gvlA:
undetectable		 5eevF-4gvlA:
10.47
5eevG-4gvlA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 ALA A 365
HIS A 359
ALA A 366
THR A 418
ILE A 416
 None
ZN  A 601 (-3.4A)
None
None
None
 1.08A 5eevF-4gvlA:
undetectable
5eevG-4gvlA:
undetectable		 5eevF-4gvlA:
10.47
5eevG-4gvlA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 12 ALA A 365
GLY A 358
ALA A 366
THR A 418
ILE A 356
 None
AMP  A 602 (-3.6A)
None
None
None
 1.11A 5eevI-4gvlA:
undetectable
5eevJ-4gvlA:
undetectable		 5eevI-4gvlA:
10.47
5eevJ-4gvlA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 12 ALA A 365
HIS A 359
ALA A 366
THR A 418
ILE A 416
 None
ZN  A 601 (-3.4A)
None
None
None
 1.06A 5eevI-4gvlA:
undetectable
5eevJ-4gvlA:
undetectable		 5eevI-4gvlA:
10.47
5eevJ-4gvlA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 GLY A 358
ALA A 366
THR A 418
ILE A 356
ALA A 365
 AMP  A 602 (-3.6A)
None
None
None
None
 1.14A 5eevQ-4gvlA:
undetectable
5eevR-4gvlA:
undetectable		 5eevQ-4gvlA:
10.47
5eevR-4gvlA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 HIS A 359
ALA A 366
THR A 418
ILE A 416
ALA A 365
 ZN  A 601 (-3.4A)
None
None
None
None
 1.07A 5eevQ-4gvlA:
undetectable
5eevR-4gvlA:
undetectable		 5eevQ-4gvlA:
10.47
5eevR-4gvlA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 ALA A 365
GLY A 358
ALA A 366
THR A 418
ILE A 356
 None
AMP  A 602 (-3.6A)
None
None
None
 1.12A 5eewF-4gvlA:
undetectable
5eewG-4gvlA:
undetectable		 5eewF-4gvlA:
10.47
5eewG-4gvlA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 ALA A 365
HIS A 359
ALA A 366
THR A 418
ILE A 416
 None
ZN  A 601 (-3.4A)
None
None
None
 1.08A 5eewF-4gvlA:
undetectable
5eewG-4gvlA:
undetectable		 5eewF-4gvlA:
10.47
5eewG-4gvlA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 12 ALA A 365
GLY A 358
ALA A 366
THR A 418
ILE A 356
 None
AMP  A 602 (-3.6A)
None
None
None
 1.11A 5eewI-4gvlA:
undetectable
5eewJ-4gvlA:
undetectable		 5eewI-4gvlA:
10.47
5eewJ-4gvlA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 12 ALA A 365
HIS A 359
ALA A 366
THR A 418
ILE A 416
 None
ZN  A 601 (-3.4A)
None
None
None
 1.06A 5eewI-4gvlA:
undetectable
5eewJ-4gvlA:
undetectable		 5eewI-4gvlA:
10.47
5eewJ-4gvlA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 GLY A 358
ALA A 366
THR A 418
ILE A 356
ALA A 365
 AMP  A 602 (-3.6A)
None
None
None
None
 1.14A 5eewQ-4gvlA:
undetectable
5eewR-4gvlA:
undetectable		 5eewQ-4gvlA:
10.47
5eewR-4gvlA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 HIS A 359
ALA A 366
THR A 418
ILE A 416
ALA A 365
 ZN  A 601 (-3.4A)
None
None
None
None
 1.07A 5eewQ-4gvlA:
undetectable
5eewR-4gvlA:
undetectable		 5eewQ-4gvlA:
10.47
5eewR-4gvlA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 ALA A 365
GLY A 358
ALA A 366
THR A 418
ILE A 356
 None
AMP  A 602 (-3.6A)
None
None
None
 1.12A 5eexF-4gvlA:
undetectable
5eexG-4gvlA:
undetectable		 5eexF-4gvlA:
10.47
5eexG-4gvlA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 ALA A 365
HIS A 359
ALA A 366
THR A 418
ILE A 416
 None
ZN  A 601 (-3.4A)
None
None
None
 1.08A 5eexF-4gvlA:
undetectable
5eexG-4gvlA:
undetectable		 5eexF-4gvlA:
10.47
5eexG-4gvlA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 ALA A 365
GLY A 358
ALA A 366
THR A 418
ILE A 356
 None
AMP  A 602 (-3.6A)
None
None
None
 1.12A 5eeyF-4gvlA:
undetectable
5eeyG-4gvlA:
undetectable		 5eeyF-4gvlA:
10.47
5eeyG-4gvlA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 ALA A 365
HIS A 359
ALA A 366
THR A 418
ILE A 416
 None
ZN  A 601 (-3.4A)
None
None
None
 1.08A 5eeyF-4gvlA:
undetectable
5eeyG-4gvlA:
undetectable		 5eeyF-4gvlA:
10.47
5eeyG-4gvlA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 ALA A 365
GLY A 358
ALA A 366
THR A 418
ILE A 356
 None
AMP  A 602 (-3.6A)
None
None
None
 1.12A 5eezF-4gvlA:
undetectable
5eezG-4gvlA:
undetectable		 5eezF-4gvlA:
10.47
5eezG-4gvlA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 ALA A 365
HIS A 359
ALA A 366
THR A 418
ILE A 416
 None
ZN  A 601 (-3.4A)
None
None
None
 1.08A 5eezF-4gvlA:
undetectable
5eezG-4gvlA:
undetectable		 5eezF-4gvlA:
10.47
5eezG-4gvlA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 ALA A 365
GLY A 358
ALA A 366
THR A 418
ILE A 356
 None
AMP  A 602 (-3.6A)
None
None
None
 1.12A 5ef0F-4gvlA:
undetectable
5ef0G-4gvlA:
undetectable		 5ef0F-4gvlA:
10.47
5ef0G-4gvlA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 ALA A 365
HIS A 359
ALA A 366
THR A 418
ILE A 416
 None
ZN  A 601 (-3.4A)
None
None
None
 1.08A 5ef0F-4gvlA:
undetectable
5ef0G-4gvlA:
undetectable		 5ef0F-4gvlA:
10.47
5ef0G-4gvlA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 ALA A 365
GLY A 358
ALA A 366
THR A 418
ILE A 356
 None
AMP  A 602 (-3.6A)
None
None
None
 1.12A 5ef1F-4gvlA:
undetectable
5ef1G-4gvlA:
undetectable		 5ef1F-4gvlA:
10.47
5ef1G-4gvlA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 ALA A 365
HIS A 359
ALA A 366
THR A 418
ILE A 416
 None
ZN  A 601 (-3.4A)
None
None
None
 1.08A 5ef1F-4gvlA:
undetectable
5ef1G-4gvlA:
undetectable		 5ef1F-4gvlA:
10.47
5ef1G-4gvlA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 ALA A 365
GLY A 358
ALA A 366
THR A 418
ILE A 356
 None
AMP  A 602 (-3.6A)
None
None
None
 1.13A 5ef2F-4gvlA:
undetectable
5ef2G-4gvlA:
undetectable		 5ef2F-4gvlA:
10.47
5ef2G-4gvlA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 ALA A 365
HIS A 359
ALA A 366
THR A 418
ILE A 416
 None
ZN  A 601 (-3.4A)
None
None
None
 1.08A 5ef2F-4gvlA:
undetectable
5ef2G-4gvlA:
undetectable		 5ef2F-4gvlA:
10.47
5ef2G-4gvlA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 ALA A 365
GLY A 358
ALA A 366
THR A 418
ILE A 356
 None
AMP  A 602 (-3.6A)
None
None
None
 1.12A 5ef3F-4gvlA:
undetectable
5ef3G-4gvlA:
undetectable		 5ef3F-4gvlA:
10.47
5ef3G-4gvlA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 ALA A 365
HIS A 359
ALA A 366
THR A 418
ILE A 416
 None
ZN  A 601 (-3.4A)
None
None
None
 1.08A 5ef3F-4gvlA:
undetectable
5ef3G-4gvlA:
undetectable		 5ef3F-4gvlA:
10.47
5ef3G-4gvlA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_1
(PROTEASE E35D-APV)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 9 ALA A 365
ILE A 356
GLY A 256
ILE A 257
ILE A 362
 None
None
None
None
AMP  A 602 (-4.3A)
 1.14A 5kr0A-4gvlA:
undetectable		 5kr0A-4gvlA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_A_ESTA601_1
(ESTROGEN RECEPTOR
BETA)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 12 ALA A 266
LEU A 338
ILE A 306
LEU A 303
LEU A 328
 None
 1.00A 5toaA-4gvlA:
undetectable		 5toaA-4gvlA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		4 / 6 ILE A 439
ILE A 426
LEU A 430
HIS A 434
 None
 1.02A 5vkqA-4gvlA:
undetectable
5vkqB-4gvlA:
undetectable		 5vkqA-4gvlA:
15.33
5vkqB-4gvlA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		4 / 6 ILE A 439
ILE A 426
LEU A 430
HIS A 434
 None
 1.00A 5vkqA-4gvlA:
undetectable
5vkqD-4gvlA:
undetectable		 5vkqA-4gvlA:
15.33
5vkqD-4gvlA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA901_0
(MRNA CAPPING ENZYME
P5)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 11 GLY A 358
ASP A 397
ALA A 398
LEU A 428
ASN A 425
 AMP  A 602 (-3.6A)
AMP  A 602 (-3.1A)
AMP  A 602 (-3.7A)
None
None
 1.17A 5x6yA-4gvlA:
undetectable		 5x6yA-4gvlA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC901_0
(MRNA CAPPING ENZYME
P5)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 11 GLY A 358
ASP A 397
ALA A 398
LEU A 428
ASN A 425
 AMP  A 602 (-3.6A)
AMP  A 602 (-3.1A)
AMP  A 602 (-3.7A)
None
None
 1.13A 5x6yC-4gvlA:
5.3		 5x6yC-4gvlA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYB_A_KKKA508_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 12 PHE A 557
ALA A 499
LEU A 496
ILE A 521
LEU A 510
 None
 1.17A 6aybA-4gvlA:
undetectable		 6aybA-4gvlA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4gvl TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		4 / 8 ILE A 199
ALA A 225
VAL A 244
ASP A 139
 None
 1.05A 6hu9a-4gvlA:
undetectable
6hu9e-4gvlA:
undetectable		 6hu9a-4gvlA:
22.24
6hu9e-4gvlA:
14.57